All Outputs (13)

Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study (2015)
Journal Article

OBJECTIVE: People with idiopathic pulmonary fibrosis (IPF) have been shown to be at an increased risk for cardiovascular (CV) disease, but reasons for this are unknown. The aim of this study was to compare the prevalence of common CV risk factors in... Read More about Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study.

In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011 (2015)
Journal Article

Rationale: Surgical lung biopsy can help to determine a specific diagnosis in interstitial lung disease, but has associated risks. Most currently available mortality data are derived from case series and may not be generalizable to broader population... Read More about In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011.

Refining adverse drug reaction signals by incorporating interaction variables identified using emergent pattern mining (2015)
Journal Article

Purpose: To develop a framework for identifying and incorporating candidate confounding interaction terms into a regularised cox regression analysis to refine adverse drug reaction signals obtained via longitudinal observational data. Methods: We co... Read More about Refining adverse drug reaction signals by incorporating interaction variables identified using emergent pattern mining.

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation (2015)
Journal Article

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC... Read More about Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

Critical care admission trends and outcomes in individuals with bronchiectasis in the UK (2015)
Journal Article

Background: There are limited data on admission trends and outcomes of individuals with bronchiectasis admitted to intensive care (ICU). Using national critical care data, we analysed admissions to ICU and estimated outcomes in terms of mortality in... Read More about Critical care admission trends and outcomes in individuals with bronchiectasis in the UK.

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank (2015)
Journal Article

Background Understanding the genetic basis of airflow obstruction and smoking behaviour is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). We used UK Biobank data to study the genetic causes of smoking behav... Read More about Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.

Patients' attitudes to risk in lung cancer surgery: a qualitative study (2015)
Journal Article

Objectives Lung cancer surgery leads to long term survival for some patients but little is known about how patients decide whether to accept the associated surgical risks. The objective of this qualitative study was to explore patients’ attitudes to... Read More about Patients' attitudes to risk in lung cancer surgery: a qualitative study.

Congenital anomalies in children of mothers taking antiepileptic drugs with and without periconceptional high dose folic acid use: a population-based cohort study (2015)
Journal Article

BACKGROUND: Antenatal antiepileptic drug (AED) use has been found to be associated with increased major congenital anomaly (CA) risks. However whether such AED-associated risks were different according to periconceptional high dose (5mg daily) folic... Read More about Congenital anomalies in children of mothers taking antiepileptic drugs with and without periconceptional high dose folic acid use: a population-based cohort study.

A supervised adverse drug reaction signalling framework imitating Bradford Hill’s causality considerations (2015)
Journal Article

Big longitudinal observational medical data potentially hold a wealth of information and have been recognised as potential sources for gaining new drug safety knowledge. Unfortunately there are many complexities and underlying issues when analysing l... Read More about A supervised adverse drug reaction signalling framework imitating Bradford Hill’s causality considerations.

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review (2015)
Journal Article

Introduction: As idiopathic pulmonary fibrosis emerges as an important public health problem, there is a need to coordinate data on incidence and mortality globally. This study aims to systematically assess all available studies to investigate the gl... Read More about Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review.

Complications and mortality in hereditary hemorrhagic telangiectasia: a population-based study (2015)
Journal Article

OBJECTIVES: Studies report that the risks of significant neurologic complications (including stroke, cerebral abscess, and migraine) and hemorrhagic sequelae are high in patients with hereditary hemorrhagic telangiectasia (HHT), and that life expe... Read More about Complications and mortality in hereditary hemorrhagic telangiectasia: a population-based study.

Prevalence of smoking among patients treated in NHS hospitals in England in 2010/11: a national audit (2015)
Journal Article

Using data from The Health Improvement Network and Hospital Episode Statistics, we investigate smoking prevalence, number of smokers treated and opportunities for cessation intervention among patients treated in National Health Service (NHS) hospital... Read More about Prevalence of smoking among patients treated in NHS hospitals in England in 2010/11: a national audit.

Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study (2015)
Journal Article

BACKGROUND: Idiopathic pulmonary fibrosis, a progressive and inevitably fatal disorder, has a highly variable clinical course. Biomarkers that reflect disease activity are urgently needed to inform patient management and for use as biomarkers of ther... Read More about Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study.