Mar�a Soler Artigas
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Artigas, Mar?a Soler; Wain, Louise V.; Miller, Suzanne; Kheirallah, Abdul Kader; Huffman, Jennifer E.; Ntalla, Ioanna; Shrine, Nick; Obeidat, Ma?en; Trochet, Holly; McArdle, Wendy L.; Alves, Alexessander Couto; Hui, Jennie; Zhao, Jing Hua; Joshi, Peter K.; Teumer, Alexander; Albrecht, Eva; Imboden, Medea; Rawal, Rajesh; Lopez, Lorna M.; Marten, Jonathan; Enroth, Stefan; Surakka, Ida; Polasek, Ozren; Lyytik?inen, Leo-Pekka; Granell, Raquel; Hysi, Pirro G.; Flexeder, Claudia; Mahajan, Anubha; Beilby, John; Boss?, Yohan; Brandsma, Corry-Anke; Campbell, Harry; Gieger, Christian; Gl?ser, Sven; Gonz?lez, Juan R.; Grallert, Harald; Hammond, Chris J.; Harris, Sarah E.; Hartikainen, Anna-Liisa; Heli?vaara, Markku; Henderson, John; Hocking, Lynne; Horikoshi, Momoko; Hutri-K?h?nen, Nina; Ingelsson, Erik; Johansson, ?sa; Kemp, John P.; Kolcic, Ivana; Kumar, Ashish; Lind, Lars; Mel?n, Erik; Musk, Arthur W.; Navarro, Pau; Nickle, David C.; Padmanabhan, Sandosh; Raitakari, Olli T.; Ried, Janina S.; R...
Authors
Louise V. Wain
Dr SUZANNE MILLER suzanne.miller@nottingham.ac.uk
Senior Clinical Studies and Project Manager
Abdul Kader Kheirallah
Jennifer E. Huffman
Ioanna Ntalla
Nick Shrine
Ma�en Obeidat
Holly Trochet
Wendy L. McArdle
Alexessander Couto Alves
Jennie Hui
Jing Hua Zhao
Peter K. Joshi
Alexander Teumer
Eva Albrecht
Medea Imboden
Rajesh Rawal
Lorna M. Lopez
Jonathan Marten
Stefan Enroth
Ida Surakka
Ozren Polasek
Leo-Pekka Lyytik�inen
Raquel Granell
Pirro G. Hysi
Claudia Flexeder
Anubha Mahajan
John Beilby
Yohan Boss�
Corry-Anke Brandsma
Harry Campbell
Christian Gieger
Sven Gl�ser
Juan R. Gonz�lez
Harald Grallert
Chris J. Hammond
Sarah E. Harris
Anna-Liisa Hartikainen
Markku Heli�vaara
John Henderson
Lynne Hocking
Momoko Horikoshi
Nina Hutri-K�h�nen
Erik Ingelsson
�sa Johansson
John P. Kemp
Ivana Kolcic
Ashish Kumar
Lars Lind
Erik Mel�n
Arthur W. Musk
Pau Navarro
David C. Nickle
Sandosh Padmanabhan
Olli T. Raitakari
Janina S. Ried
Samuli Ripatti
Holger Schulz
Robert A. Scott
Don D. Sin
John M. Starr
Panos Deloukas
Anna L. Hansell
Richard Hubbard
Victoria E. Jackson
Jonathan Marchini
Ian Pavord
Neil C. Thomson
Eleftheria Zeggini
Ana Vi�uela
Henry V�lzke
Sarah H. Wild
Alan F. Wright
Tatijana Zemunik
Deborah L. Jarvis
Tim D. Spector
David M. Evans
Terho Lehtim�ki
Veronique Vitart
Mika K�h�nen
Ulf Gyllensten
Igor Rudan
Ian J. Deary
Stefan Karrasch
Nicole M. Probst-Hensch
Joachim Heinrich
Beate Stubbe
James F. Wilson
Nicholas J. Wareham
Alan L. James
Andrew P. Morris
Marjo-Riitta Jarvelin
Caroline Hayward
Professor IAN SAYERS ian.sayers@nottingham.ac.uk
Professor of Respiratory Molecular Genetics
David P. Strachan
IAN HALL IAN.HALL@NOTTINGHAM.AC.UK
Professor of Molecular Medicine
Martin D. Tobin
Abstract
Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.
Citation
Artigas, M. S., Wain, L. V., Miller, S., Kheirallah, A. K., Huffman, J. E., Ntalla, I., Shrine, N., Obeidat, M., Trochet, H., McArdle, W. L., Alves, A. C., Hui, J., Zhao, J. H., Joshi, P. K., Teumer, A., Albrecht, E., Imboden, M., Rawal, R., Lopez, L. M., Marten, J., …Tobin, M. D. (2015). Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6, 1-12. https://doi.org/10.1038/ncomms9658
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Sep 17, 2015 |
| Online Publication Date | Dec 4, 2015 |
| Publication Date | Dec 4, 2015 |
| Deposit Date | Apr 5, 2016 |
| Publicly Available Date | Apr 5, 2016 |
| Journal | Nature Communications |
| Electronic ISSN | 2041-1723 |
| Publisher | Nature Publishing Group |
| Peer Reviewed | Peer Reviewed |
| Volume | 6 |
| Article Number | 8658 |
| Pages | 1-12 |
| DOI | https://doi.org/10.1038/ncomms9658 |
| Public URL | https://nottingham-repository.worktribe.com/output/980492 |
| Publisher URL | https://www.nature.com/articles/ncomms9658 |
| Contract Date | Apr 5, 2016 |
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Copyright Statement
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