Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Artigas, Mar�a Soler; Wain, Louise V.; Miller, Suzanne; Kheirallah, Abdul Kader; Huffman, Jennifer E.; Ntalla, Ioanna; Shrine, Nick; Obeidat, Ma�en; Trochet, Holly; McArdle, Wendy L.; Alves, Alexessander Couto; Hui, Jennie; Zhao, Jing Hua; Joshi, Peter K.; Teumer, Alexander; Albrecht, Eva; Imboden, Medea; Rawal, Rajesh; Lopez, Lorna M.; Marten, Jonathan; Enroth, Stefan; Surakka, Ida; Polasek, Ozren; Lyytik�inen, Leo-Pekka; Granell, Raquel; Hysi, Pirro G.; Flexeder, Claudia; Mahajan, Anubha; Beilby, John; Boss�, Yohan; Brandsma, Corry-Anke; Campbell, Harry; Gieger, Christian; Gl�ser, Sven; Gonz�lez, Juan R.; Grallert, Harald; Hammond, Chris J.; Harris, Sarah E.; Hartikainen, Anna-Liisa; Heli�vaara, Markku; Henderson, John; Hocking, Lynne; Horikoshi, Momoko; Hutri-K�h�nen, Nina; Ingelsson, Erik; Johansson, �sa; Kemp, John P.; Kolcic, Ivana; Kumar, Ashish; Lind, Lars; Mel�n, Erik; Musk, Arthur W.; Navarro, Pau; Nickle, David C.; Padmanabhan, Sandosh; Raitakari, Olli T.; Ried, Janina S.; Ripatti, Samuli; Schulz, Holger; Scott, Robert A.; Sin, Don D.; Starr, John M.; Deloukas, Panos; Hansell, Anna L.; Hubbard, Richard; Jackson, Victoria E.; Marchini, Jonathan; Pavord, Ian; Thomson, Neil C.; Zeggini, Eleftheria; Vi�uela, Ana; V�lzke, Henry; Wild, Sarah H.; Wright, Alan F.; Zemunik, Tatijana; Jarvis, Deborah L.; Spector, Tim D.; Evans, David M.; Lehtim�ki, Terho; Vitart, Veronique; K�h�nen, Mika; Gyllensten, Ulf; Rudan, Igor; Deary, Ian J.; Karrasch, Stefan; Probst-Hensch, Nicole M.; Heinrich, Joachim; Stubbe, Beate; Wilson, James F.; Wareham, Nicholas J.; James, Alan L.; Morris, Andrew P.; Jarvelin, Marjo-Riitta; Hayward, Caroline; Sayers, Ian; Strachan, David P.; Hall, Ian P.; Tobin, Martin D.

doi:10.1038/ncomms9658

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Artigas, Mar?a Soler; Wain, Louise V.; Miller, Suzanne; Kheirallah, Abdul Kader; Huffman, Jennifer E.; Ntalla, Ioanna; Shrine, Nick; Obeidat, Ma?en; Trochet, Holly; McArdle, Wendy L.; Alves, Alexessander Couto; Hui, Jennie; Zhao, Jing Hua; Joshi, Peter K.; Teumer, Alexander; Albrecht, Eva; Imboden, Medea; Rawal, Rajesh; Lopez, Lorna M.; Marten, Jonathan; Enroth, Stefan; Surakka, Ida; Polasek, Ozren; Lyytik?inen, Leo-Pekka; Granell, Raquel; Hysi, Pirro G.; Flexeder, Claudia; Mahajan, Anubha; Beilby, John; Boss?, Yohan; Brandsma, Corry-Anke; Campbell, Harry; Gieger, Christian; Gl?ser, Sven; Gonz?lez, Juan R.; Grallert, Harald; Hammond, Chris J.; Harris, Sarah E.; Hartikainen, Anna-Liisa; Heli?vaara, Markku; Henderson, John; Hocking, Lynne; Horikoshi, Momoko; Hutri-K?h?nen, Nina; Ingelsson, Erik; Johansson, ?sa; Kemp, John P.; Kolcic, Ivana; Kumar, Ashish; Lind, Lars; Mel?n, Erik; Musk, Arthur W.; Navarro, Pau; Nickle, David C.; Padmanabhan, Sandosh; Raitakari, Olli T.; Ried, Janina S.; R...

Authors

Mar�a Soler Artigas

Louise V. Wain

Dr SUZANNE MILLER suzanne.miller@nottingham.ac.uk
Senior Clinical Studies and Project Manager

Abdul Kader Kheirallah

Jennifer E. Huffman

Ioanna Ntalla

Nick Shrine

Ma�en Obeidat

Holly Trochet

Wendy L. McArdle

Alexessander Couto Alves

Jennie Hui

Jing Hua Zhao

Peter K. Joshi

Alexander Teumer

Eva Albrecht

Medea Imboden

Rajesh Rawal

Lorna M. Lopez

Jonathan Marten

Stefan Enroth

Ida Surakka

Ozren Polasek

Leo-Pekka Lyytik�inen

Raquel Granell

Pirro G. Hysi

Claudia Flexeder

Anubha Mahajan

John Beilby

Yohan Boss�

Corry-Anke Brandsma

Harry Campbell

Christian Gieger

Sven Gl�ser

Juan R. Gonz�lez

Harald Grallert

Chris J. Hammond

Sarah E. Harris

Anna-Liisa Hartikainen

Markku Heli�vaara

John Henderson

Lynne Hocking

Momoko Horikoshi

Nina Hutri-K�h�nen

Erik Ingelsson

�sa Johansson

John P. Kemp

Ivana Kolcic

Ashish Kumar

Lars Lind

Erik Mel�n

Arthur W. Musk

Pau Navarro

David C. Nickle

Sandosh Padmanabhan

Olli T. Raitakari

Janina S. Ried

Samuli Ripatti

Holger Schulz

Robert A. Scott

Don D. Sin

John M. Starr

Panos Deloukas

Anna L. Hansell

RICHARD HUBBARD richard.hubbard@nottingham.ac.uk
Blf/Gsk Professor of Epidemiological Resp Research

Victoria E. Jackson

Jonathan Marchini

Ian Pavord

Neil C. Thomson

Eleftheria Zeggini

Ana Vi�uela

Henry V�lzke

Sarah H. Wild

Alan F. Wright

Tatijana Zemunik

Deborah L. Jarvis

Tim D. Spector

David M. Evans

Terho Lehtim�ki

Veronique Vitart

Mika K�h�nen

Ulf Gyllensten

Igor Rudan

Ian J. Deary

Stefan Karrasch

Nicole M. Probst-Hensch

Joachim Heinrich

Beate Stubbe

James F. Wilson

Nicholas J. Wareham

Alan L. James

Andrew P. Morris

Marjo-Riitta Jarvelin

Caroline Hayward

Professor IAN SAYERS ian.sayers@nottingham.ac.uk
Professor of Respiratory Molecular Genetics

David P. Strachan

IAN HALL IAN.HALL@NOTTINGHAM.AC.UK
Professor of Molecular Medicine

Martin D. Tobin

Abstract

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P

Journal Article Type	Article
Acceptance Date	Sep 17, 2015
Online Publication Date	Dec 4, 2015
Publication Date	Dec 4, 2015
Deposit Date	Apr 5, 2016
Publicly Available Date	Apr 5, 2016
Journal	Nature Communications
Electronic ISSN	2041-1723
Publisher	Nature Publishing Group
Peer Reviewed	Peer Reviewed
Volume	6
Article Number	8658
Pages	1-12
DOI	https://doi.org/10.1038/ncomms9658
Public URL	https://nottingham-repository.worktribe.com/output/980492
Publisher URL	https://www.nature.com/articles/ncomms9658