All Outputs (22)

The Impact of High BMI on Pregnancy Outcomes and Complications in Women with PCOS Undergoing IVF - A Systematic Review and Meta-Analysis (2024)
Journal Article

(1) Background: Current evidence indicates that women with polycystic ovarian syndrome (PCOS) undergoing in vitro fertilization (IVF) have an increased likelihood of adverse pregnancy outcomes. The objective of this systematic review was to clarify t... Read More about The Impact of High BMI on Pregnancy Outcomes and Complications in Women with PCOS Undergoing IVF - A Systematic Review and Meta-Analysis.

Evaluating the effect of maternal non-communicable disease on adverse pregnancy outcomes and birthweight in Pakistan, a facility based retrospective cohort study (2024)
Journal Article

Non-communicable diseases (NCDs) claim 74% of global lives, disproportionately affecting lower and middle-income countries like Pakistan. NCDs may increase the risk of preterm birth (PTB), caesarean section (CS), and low birthweight. This study aims... Read More about Evaluating the effect of maternal non-communicable disease on adverse pregnancy outcomes and birthweight in Pakistan, a facility based retrospective cohort study.

Evaluating the effect of maternal non-communicable disease on adverse pregnancy outcomes and birthweight in Pakistan, a facility based retrospective cohort study (2024)
Journal Article

Background: Non-communicable diseases (NCDs) claim 74% of global lives, disproportionately affecting lower and middle-income countries like Pakistan. NCDs may increase the risk of preterm birth (PTB), caesarean section (CS), and low birthweight. This... Read More about Evaluating the effect of maternal non-communicable disease on adverse pregnancy outcomes and birthweight in Pakistan, a facility based retrospective cohort study.

The Role of NLRP3 Inflammasome in Obesity and PCOS — A Systematic Review and Meta-Analysis (2023)
Journal Article

Inflammasomes have recently been implicated in the pathogenesis of several chronic inflammatory disorders, such as diabetes and obesity. The aim of this meta-analysis was to investigate the possible role of the NLRP3 inflammasome in obesity and polyc... Read More about The Role of NLRP3 Inflammasome in Obesity and PCOS — A Systematic Review and Meta-Analysis.

The impact of maternal obesity on in vivo uterine contractile activity during parturition in the rat (2023)
Journal Article

Maternal obesity is associated with increased risk of prolonged and dysfunctional labor and emergency caesarean section. To elucidate the mechanisms behind the associated uterine dystocia, a translational animal model is required. Our previous work i... Read More about The impact of maternal obesity on in vivo uterine contractile activity during parturition in the rat.

Ion channels as therapeutic targets in high grade gliomas (2020)
Journal Article

Abstract: Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14-15 months with maximal treatment. High grade gliomas (HGG) form a leading cause of CNS cancer-related death in children and adults due to the aggressive n... Read More about Ion channels as therapeutic targets in high grade gliomas.

Ion channels as therapeutic targets in high grade gliomas (2020)
Journal Article

Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14-15 months with maximal treatment. High grade gliomas (HGG) form a leading cause of CNS cancer-related death in children and adults due to the aggressive nature of t... Read More about Ion channels as therapeutic targets in high grade gliomas.

Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome (2019)
Journal Article

Introduction Pre-eclampsia is a hypertensive gestational disorder that affects approximately 5% of all pregnancies. Objectives As the pathophysiological processes of pre-eclampsia are still uncertain, the present case–control study explored unde... Read More about Untargeted analysis of plasma samples from pre-eclamptic women reveals polar and apolar changes in the metabolome.

Expression of cholesterol packaging and transport genes in human and rat placenta: impact of obesity and a high-fat diet (2019)
Journal Article

Evidence suggests that sub-optimal maternal nutrition has implications for the developing offspring. We have previously shown that exposure to a low-protein diet during gestation was associated with upregulation of genes associated with cholesterol t... Read More about Expression of cholesterol packaging and transport genes in human and rat placenta: impact of obesity and a high-fat diet.

Pharmacological profile of vascular activity of human stem villous arteries (2019)
Journal Article

© 2019 Introduction: The function of the placental vasculature differs considerably from other systemic vascular beds of the human body. A detailed understanding of the normal placental vascular physiology is the foundation to understand perturbed co... Read More about Pharmacological profile of vascular activity of human stem villous arteries.

Excess androgen production in subcutaneous adipose tissue of women with polycystic ovarian syndrome (2019)
Journal Article

© 2019 Society for Endocrinology Published by Bioscientifica Ltd. The purpose of this study was to investigate androgen production and the role of insulin and LH in its regulation in subcutaneous adipose tissue (SAT) of women with polycystic ovarian... Read More about Excess androgen production in subcutaneous adipose tissue of women with polycystic ovarian syndrome.

Evaluation of extraction and normalisation strategies for the analysis of lipids in placental vessels (2018)
Journal Article

© 2018 The analysis of lipids in tough or fibrous biological tissues can be challenging due to difficulties in obtaining a representative sample following homogenisation of the tissue. Furthermore, the choice of normalisation method can have a major... Read More about Evaluation of extraction and normalisation strategies for the analysis of lipids in placental vessels.

Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception (2018)
Journal Article

Maternal obesity is associated with prolonged and dysfunctional labour, potentially through decreased synthesis of prostaglandins that stimulate myometrial contractions. We assessed the impact of maternal obesity on concentrations of precursor fatty... Read More about Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids during labour is reversed through improved nutrition at conception.

The role of oxidative stress in antipsychotics induced ovarian toxicity (2017)
Journal Article

This study tested the hypothesis that oxidative stress could be an underlying mechanism for APs-induced ovarian cytotoxicity and reproductive dysfunction. Rat ovarian theca interstitial cells (TICs) were isolated and treated with four APs [chlorproma... Read More about The role of oxidative stress in antipsychotics induced ovarian toxicity.

Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women (2017)
Journal Article

OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory m... Read More about Gene expression of inflammatory markers in adipose tissue between obese women with polycystic ovary and normal obese women.

Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells (2017)
Journal Article

Background Antipsychotics (APs) are widely prescribed drugs, which are well known to cause reproductive adverse effects through mechanisms yet to be determined. The purpose of this study was to investigate the effect of antipsychotics on mitochond... Read More about Effect of antipsychotics on mitochondrial bioenergetics of rat ovarian theca cells.

Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome (2016)
Journal Article

This study examined whether a defect of steroid synthesis in ovarian theca cells may lead to the development of PCOS, through contributions to excess androgen secretion. Polycystic ovarian syndrome (PCOS) is one of the leading causes of infertilit... Read More about Thecal cell sensitivity to luteinizing hormone and insulin in polycystic ovarian syndrome.

Modelling maternal obesity: the effects of a chronic high-fat, high-cholesterol diet on uterine expression of contractile-associated proteins and ex vivo contractile activity during labour in the rat (2015)
Journal Article

Maternal obesity is associated with prolonged and dysfunctional labour and emergency caesarean section, but the mechanisms are unknown. The present study investigated the effects of an adiposity-inducing high fat, high-cholesterol (HFHC) diet on uter... Read More about Modelling maternal obesity: the effects of a chronic high-fat, high-cholesterol diet on uterine expression of contractile-associated proteins and ex vivo contractile activity during labour in the rat.

P-699, Androgen synthesis in peripheral adipose tissue: the role of insulin and luteinizing hormone in women with polycystic ovarian syndrome (2015)
Journal Article

O-011, The role of subcutaneous adipose tissue in the development of hyperandrogenism in PCOS (2014)
Journal Article