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Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461) (2014)
Journal Article
Sprigg, N., Renton, C. J., Dineen, R. A., Kwong, Y., & Bath, P. M. (2014). Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461). Journal of Stroke and Cerebrovascular Diseases, 23(6), 1312-1318. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.11.007

Background: Spontaneous intracerebral hemorrhage (ICH) can be devastating, particularly if hematoma expansion (HE) occurs. Tranexamic acid (TA), an antifibrinolytic drug, significantly reduced mortality in bleeding patients after trauma in the large... Read More about Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461).

Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial (2014)
Journal Article
Bath, P. M., Houlton, A., Woodhouse, L. J., Sprigg, N., Wardlaw, J. M., & Pocock, S. J. (in press). Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial. International Journal of Stroke, 9(3), https://doi.org/10.1111/ijs.12235

High blood pressure is common during the acute phase of stroke and is associated with a poor outcome. However, the management of high blood pressure remains unclear. The ‘Efficacy of Nitric Oxide in Stroke’ trial tested whether transdermal glyceryl t... Read More about Statistical analysis plan for the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial.

Effect of telmisartan on functional outcome, recurrence, and blood pressure in patients with acute mild ischemic stroke: a PRoFESS subgroup analysis (2009)
Journal Article
Bath, P. M., Martin, R. H., Palesch, Y., Cotton, D., Yusuf, S., Sacco, R. L., …Roberts, R. (2009). Effect of telmisartan on functional outcome, recurrence, and blood pressure in patients with acute mild ischemic stroke: a PRoFESS subgroup analysis. Stroke, 40(11), 3541-3546. https://doi.org/10.1161/strokeaha.109.555623

Background and Purpose: High blood pressure (BP) is common in acute ischemic stroke and associated independently with a poor functional outcome. However, the management of BP acutely remains unclear because no large trials have been completed. Metho... Read More about Effect of telmisartan on functional outcome, recurrence, and blood pressure in patients with acute mild ischemic stroke: a PRoFESS subgroup analysis.

Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review (2009)
Journal Article
England, T. J., Gibson, C. L., & Bath, P. M. (2009). Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review. Brain Research, 62(1), 71-82. https://doi.org/10.1016/j.brainresrev.2009.09.002

Background: Granulocyte-colony stimulating factor (G-CSF) shows promise as a treatment for stroke. This systematic review assesses G-CSF in experimental ischaemic stroke. Methods: Relevant studies were identified with searches of Medline, Embase and... Read More about Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review.

Relationship between therapeutic changes in blood pressure and outcomes in acute stroke: a metaregression (2009)
Journal Article
Geeganage, C., & Bath, P. M. (in press). Relationship between therapeutic changes in blood pressure and outcomes in acute stroke: a metaregression. Hypertension, 54(4), https://doi.org/10.1161/hypertensionaha.109.133538

Both low and high blood pressure (BP) during the acute phase of stroke are associated independently with a poor outcome. Several small clinical trials have involved the alteration of BP and this study assessed the relationship between change in BP an... Read More about Relationship between therapeutic changes in blood pressure and outcomes in acute stroke: a metaregression.

Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA Collaboration (2009)
Journal Article
Sare, G. M., Ali, M., Shuaib, A., & Bath, P. M. (2009). Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA Collaboration. Stroke, 40(6), https://doi.org/10.1161/STROKEAHA.108.539155

Background and Purpose—High blood pressure (BP) is associated independently with poor outcome after acute ischemic stroke, although in most analyses “baseline” BP was measured 24 hours or more postictus, and not during the hyperacute period. Methods... Read More about Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA Collaboration.

Speeding stroke recovery? A systematic review of amphetamine after stroke (2009)
Journal Article
Sprigg, N., & Bath, P. M. (2009). Speeding stroke recovery? A systematic review of amphetamine after stroke. Journal of the Neurological Sciences, 285(1-2), 3-9. https://doi.org/10.1016/j.jns.2009.04.040

Introduction: The use of drugs to enhance recovery (“rehabilitation pharmacology”) has been assessed. Amphetamine can improve outcome in experimental models of stroke, and several small clinical trials have assessed its use in stroke. Methods: Elec... Read More about Speeding stroke recovery? A systematic review of amphetamine after stroke.

Good laboratory practice: preventing introduction of bias at the bench (2009)
Journal Article
Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M., …Howells, D. W. (2009). Good laboratory practice: preventing introduction of bias at the bench. Stroke, 40(3), Article e50-e52

Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review—Accumulating evidence sugge... Read More about Good laboratory practice: preventing introduction of bias at the bench.

The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST) (2009)
Journal Article
Sare, G. M., Bath, P. M., Gray, L. J., Moulin, T., Woimant, F., England, T., …Ringelstein, B. (2009). The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Stroke, 40(1), https://doi.org/10.1161/STROKEAHA.108.526665

Background and Purpose—High blood pressure (BP) is present in 80% of patients with acute ischemic stroke and is independently associated with poor outcome. There are few data examining the relationship between admission BP and acute CT findings. M... Read More about The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST).

Systematic reviews as a tool for planning and interpreting trials (2009)
Journal Article
Bath, P. M., & Gray, L. J. (2009). Systematic reviews as a tool for planning and interpreting trials. International Journal of Stroke, 4(1),

Background Systematic reviews followed by ameta-analysis are carried out in medical research to combine the results of two or more related studies. Stroke trials have struggled to show beneficial effects and meta-analysis should be used more widely... Read More about Systematic reviews as a tool for planning and interpreting trials.

Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk (2008)
Journal Article
Halkes, P., Gray, L. J., Bath, P. M., Diener, H., & Guiraud-Chaumeil, B. (2008). Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk. Journal of Neurology, Neurosurgery and Psychiatry, 79(11), https://doi.org/10.1136/jnnp.2008.143875

Objectives: Our aim was to study the effect of combination therapy with aspirin and dipyridamole (A+D) over aspirin alone (ASA) in secondary prevention after transient ischemic attack or minor stroke of presumed arterial origin and to perform subgr... Read More about Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk.

Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events (2008)
Journal Article
Yusuf, S., Diener, H., Sacco, R. L., Cotton, D., Ounpuu, S., Lawton, W. A., …Yoon, B. (2008). Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events. New England Journal of Medicine, 359(12), 1225-1237. https://doi.org/10.1056/nejmoa0804593

Background Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin–angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including str... Read More about Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events.

Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke (2008)
Journal Article
Sacco, R. L., Diener, H., Yusuf, S., Cotton, D., Ounpuu, S., Lawton, W. A., …Yoon, B. (2008). Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. New England Journal of Medicine, 359(12), 1238-1251. https://doi.org/10.1056/NEJMoa0805002

Background: Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens — aspirin plus extended release dipyridamole (ASA–ERDP) versus clopidogrel. Methods: In this... Read More about Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke.

Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials (2008)
Journal Article
Bath, P. M., Geeganage, C., Gray, L. J., Collier, T., & Pocock, S. (2008). Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials. Stroke, 39(10), https://doi.org/10.1161/STROKEAHA.107.509893

Background and Purpose—Vascular prevention trials mostly count “yes/no” (binary) outcome events, eg, stroke/no stroke. Analysis of ordered categorical vascular events (eg, fatal stroke/nonfatal stroke/no stroke) is clinically relevant and could be... Read More about Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials.