Philip M.W. Bath
Systematic reviews as a tool for planning and interpreting trials
Bath, Philip M.W.; Gray, Laura J.
Laura J. Gray
Background Systematic reviews followed by ameta-analysis
are carried out in medical research to combine the results of two or more related studies. Stroke trials have struggled to show beneficial effects and meta-analysis should be used more widely throughout the research process to either speed up the development of useful interventions, or halt more quickly research with hazardous or ineffective interventions.
Summary of review. This review summarises the clinical research process and illustrates how and when systematic
reviews may be used throughout the development programme.
Meta-analyses should be performed after observational
studies, preclinical studies in experimental stroke, and
after phase I, II, and III clinical trials and phase IV clinical surveillance studies. Although meta-analyses most commonly work with summary data, they may be performed to assess relationships between variables (meta-regression) and, ideally, should utilise individual patient data. Meta-analysis techniques may alsoworkwith ordered categorical outcome data (ordinal meta-analysis) and be used to perform indirect comparisons where original trial data do not exist.
Conclusion Systematic review/meta-analyses are powerful
tools in medical research and should be used throughout
the development of all stroke and other interventions
|Journal Article Type||Article|
|Publication Date||Jan 1, 2009|
|Journal||International Journal of Stroke|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Bath, P. M., & Gray, L. J. (2009). Systematic reviews as a tool for planning and interpreting trials. International Journal of Stroke, 4(1),|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf|
|Additional Information||The definitive version is available at: www.blackwell-synergy.com|
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
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