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Good laboratory practice: preventing introduction of bias at the bench

Macleod, Malcolm R.; Fisher, Marc; O'Collins, Victoria; Sena, Emily S.; Dirnagl, Ulrich; Bath, Philip M.W.; Buchan, Alistair; van der Worp, H. Bart; Traystman, Richard; Minematsu, Kazuo; Donnan, Geoffrey A.; Howells, David W.

Authors

Malcolm R. Macleod

Marc Fisher

Victoria O'Collins

Emily S. Sena

Ulrich Dirnagl

Philip M.W. Bath

Alistair Buchan

H. Bart van der Worp

Richard Traystman

Kazuo Minematsu

Geoffrey A. Donnan

David W. Howells



Abstract

Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial
efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.

Summary of Review—Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct
and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective
efficacy.

Conclusions—Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal
experiments modeling human stroke.

Journal Article Type Article
Publication Date Mar 1, 2009
Journal Stroke
Print ISSN 0039-2499
Electronic ISSN 0039-2499
Publisher American Heart Association
Peer Reviewed Peer Reviewed
Volume 40
Issue 3
Article Number e50-e52
APA6 Citation Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M., …Howells, D. W. (2009). Good laboratory practice: preventing introduction of bias at the bench. Stroke, 40(3),
Publisher URL http://stroke.ahajournals.org/cgi/content/full/40/3/e50
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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