Malcolm R. Macleod
Good laboratory practice: preventing introduction of bias at the bench
Macleod, Malcolm R.; Fisher, Marc; O'Collins, Victoria; Sena, Emily S.; Dirnagl, Ulrich; Bath, Philip M.W.; Buchan, Alistair; van der Worp, H. Bart; Traystman, Richard; Minematsu, Kazuo; Donnan, Geoffrey A.; Howells, David W.
Emily S. Sena
Philip M.W. Bath
H. Bart van der Worp
Geoffrey A. Donnan
David W. Howells
Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial
efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.
Summary of Review—Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct
and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective
Conclusions—Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal
experiments modeling human stroke.
|Journal Article Type||Article|
|Publication Date||Mar 1, 2009|
|Publisher||American Heart Association|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M., …Howells, D. W. (2009). Good laboratory practice: preventing introduction of bias at the bench. Stroke, 40(3),|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf|
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
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