All Outputs (198)

Stroke outcome in clinical trial patients deriving from different countries (2008)
Journal Article

Background and Purpose—Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations rem... Read More about Stroke outcome in clinical trial patients deriving from different countries.

A randomised controlled trial of triple antiplatelet therapy (Aspirin, Clopidogrel and Dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility (2008)
Journal Article

Background: Aspirin, dipyridamole and clopidogrel are effective in secondary vascular prevention. Combination therapy with three antiplatelet agents might maximise the benefit of antiplatelet treatment in the secondary prevention of ischaemic stroke.... Read More about A randomised controlled trial of triple antiplatelet therapy (Aspirin, Clopidogrel and Dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility.

Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials (2008)
Journal Article

Background and Purpose—An early and reliable prognosis for recovery in stroke patients is important for initiation of individual treatment and for informing patients and relatives. We recently developed and validated models for predicting survival a... Read More about Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials.

Should data monitoring committees assess efficacy when considering safety in trails in acute stroke? (2007)
Journal Article

The primary role of a trials Data Monitoring Committee (DMC) is to ensure the safety of enrolled patients. In stroke trials, safety is monitored typically by comparing death and stroke specific events between treatment groups. DMCs may also have the... Read More about Should data monitoring committees assess efficacy when considering safety in trails in acute stroke?.

Sex differences in quality of life in stroke survivors. Data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST) (2007)
Journal Article

Introduction: Female sex is predictive of poor functional outcome in stroke, even after correction for prognostic factors. Poor quality of life (QoL) is observed in stroke survivors, with lower scores seen in the most disabled patients. We used data... Read More about Sex differences in quality of life in stroke survivors. Data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST).

High blood pressure in acute stroke: to treat or not to treat (2007)
Journal Article

Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials (2007)
Journal Article

Background and Purpose—Most large acute stroke trials have been neutral. Functional outcome is usually analyzed usinga yes or no answer, eg, death or dependency versus independence. We assessed which statistical approaches are mostefficient in analyz... Read More about Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials.

Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST) (2007)
Journal Article

Introduction: Baseline severity and clinical stroke syndrome (Oxford Community Stroke Project, OCSP) classification are predictors of outcome in stroke. We used data from the ‘Tinzaparin in Acute Ischaemic Stroke Trial’ (TAIST) to assess the relation... Read More about Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST).

Is there a link between aspirin therapy and stroke severity (2007)
Journal Article

Published by: http://npg.nature.com/

Colony stimulating factors (blood growth factors) are promising but unproven for treating stroke (2007)
Journal Article

Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomized controlled trial (ISRCTN 36285333) (2007)
Journal Article

Amphetamine enhances recovery after experimental ischaemia and has shown promise in small clinical trials when combined with motor or sensory stimulation. Amphetamine, a sympathomimetic, might have haemodynamic effects in stroke patients, although li... Read More about Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomized controlled trial (ISRCTN 36285333).

Effect of nitric oxide donors on blood pressure and pulse pressure in acute and subacute stroke (2006)
Journal Article

High blood pressure (BP), pulse pressure (PP), and rate pressure product (RPP) areeach associated independently with a poor outcome in acute ischemic stroke. Whereas nitric oxide (NO) donors, such as glyceryl trinitrate (GTN), lower blood pressure i... Read More about Effect of nitric oxide donors on blood pressure and pulse pressure in acute and subacute stroke.

Control of blood pressure after stroke (2006)
Journal Article

Significant variation in mortality and functional outcome after acute ischaemic stroke between western countries: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial' (TAIST) (2006)
Journal Article

Association between hormone replacement therapy and subsequent stroke: a meta analysis (2005)
Journal Article

Compression stockings and the prevention of symptomatic venous thromboembolism: data from the Tinzaparin in Acute Ischaemic Stroke Trial (2005)
Journal Article

Background: Venous thromboembolism (VTE) is a well recognised and preventable complication of acute stroke. While graduated compression stockings reduce the risk of VTE in surgical patients their benefit in acute stroke remains uncertain. Methods: T... Read More about Compression stockings and the prevention of symptomatic venous thromboembolism: data from the Tinzaparin in Acute Ischaemic Stroke Trial.

Nitric oxide synthase inhibitors in experimental stroke and their effects on infarct size and cerebral blood flow: a systematic review (2005)
Journal Article

A systematic review of nitric oxide donors and L-arginine in experimental stroke: effects on infarct size and cerebral blood flow (2005)
Journal Article

Background: Nitric oxide (NO) is a candidate treatment for acute ischaemic stroke, however published studies in experimental stroke have given conflicting results. Methods: We performed a systematic review of published controlled studies of L-arginin... Read More about A systematic review of nitric oxide donors and L-arginine in experimental stroke: effects on infarct size and cerebral blood flow.