Laura J. Gray
Effect of nitric oxide donors on blood pressure and pulse pressure in acute and subacute stroke
Gray, Laura J.; Sprigg, Nikola; Rashid, Parveen; Willmot, Mark; Bath, Philip M.W.
Authors
NIKOLA SPRIGG nikola.sprigg@nottingham.ac.uk
Professor of Stroke Medicine
Parveen Rashid
Mark Willmot
Philip M.W. Bath
Abstract
High blood pressure (BP), pulse pressure (PP), and rate pressure product (RPP) areeach associated independently with a poor outcome in acute ischemic stroke.
Whereas nitric oxide (NO) donors, such as glyceryl trinitrate (GTN), lower blood pressure in acute ischemic stroke, their effect on other hemodynamic measures is not known. We performed a systematic review of the effects of NO donors on systemic hemodynamic measures in patients with acute/subacute stroke. Randomized controlled trials were identified from searches of the Cochrane Library, Pubmed, and Embase. Information on hemodynamic measures, including systolic BP (SBP), diastolic BP (DBP), and heart rate, were assessed, and hemodynamic derivatives of these were calculated: PP (PP SBP DBP), mean arterial pressure (MAP DBP PP/3), mid blood pressure (MBP (SBP DBP)/2), pulse pressure index (PPI PP/MAP), and RPP (RPP SBP HR). The effect of treatment on hemodynamic measures was calculated as the weighted mean difference (WMD) between treated and control groups with adjustment for baseline.
Results: Three trials involving 145 patients were identified; 93 patients received the NO donor, GTN, and 52 control. As compared with placebo, GTN significantly reduced SBP (WMD -9.80 mmHg, p< 0.001), DBP (WMD -4.43 mmHg, p
Citation
Gray, L. J., Sprigg, N., Rashid, P., Willmot, M., & Bath, P. M. (2006). Effect of nitric oxide donors on blood pressure and pulse pressure in acute and subacute stroke. Journal of Stroke and Cerebrovascular Diseases, 15(6),
| Journal Article Type | Article |
|---|---|
| Publication Date | Nov 1, 2006 |
| Deposit Date | Mar 1, 2007 |
| Publicly Available Date | Oct 9, 2007 |
| Journal | Journal of Stroke and Cerebrovascular Disease |
| Print ISSN | 1052-3057 |
| Publisher | Elsevier |
| Peer Reviewed | Peer Reviewed |
| Volume | 15 |
| Issue | 6 |
| Public URL | https://nottingham-repository.worktribe.com/output/1018188 |
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