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A novel small molecule ZYZ384 targeting SMYD3 for hepatocellular carcinoma via reducing H3K4 trimethylation of the Rac1 promoter (2024)
Journal Article
Ding, Q., Cai, J., Jin, L., Hu, W., Song, W., Rose, P., Tang, Z., Zhan, Y., Bao, L., Lei, W., & Zhu, Y. Z. (2024). A novel small molecule ZYZ384 targeting SMYD3 for hepatocellular carcinoma via reducing H3K4 trimethylation of the Rac1 promoter. MedComm, 5(10), Article e711. https://doi.org/10.1002/mco2.711

SMYD3 (SET and MYND domain-containing 3) is a histone lysine methyltransferase highly expressed in different types of cancer(s) and is a promising epigenetic target for developing novel antitumor therapeutics. No selective inhibitors for this protein... Read More about A novel small molecule ZYZ384 targeting SMYD3 for hepatocellular carcinoma via reducing H3K4 trimethylation of the Rac1 promoter.

Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis (2024)
Journal Article
Mu, G., Peng, F., Zhang, Z., M. Brameld, J., Rose, P., Yang, X., Jiang, Z.-J., He, X., & Tang, B. (2024). Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis. Journal of Drug Delivery Science and Technology, 101(Part A), Article 106151. https://doi.org/10.1016/j.jddst.2024.106151

This study designed and developed a novel three-layer electrostatic, slow-releasing nanoparticle drug delivery system for the treatment of ulcerative colitis. The nanoparticles were composed of layers of zein-based polydopamine, chitosan and cellulos... Read More about Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis.

Who consumes anthocyanins and anthocyanidins? Mining national retail data to reveal the influence of socioeconomic deprivation and seasonality on polyphenol dietary intake (2023)
Presentation / Conference Contribution
Harvey, J., Long, G., Welham, S., Mansilla, R., Rose, P., Thomas, M., …Goulding, J. (2023). Who consumes anthocyanins and anthocyanidins? Mining national retail data to reveal the influence of socioeconomic deprivation and seasonality on polyphenol dietary intake. In Proceedings: 2023 IEEE International Conference on Big Data (BigData) (4530-4538). https://doi.org/10.1109/BigData59044.2023.10386220

Anthocyanins are a class of polyphenols that have received widespread recent attention due to their potential health benefits. However, estimating the dietary intake of anthocyanins at a population level is a challenging task, due to the difficulty o... Read More about Who consumes anthocyanins and anthocyanidins? Mining national retail data to reveal the influence of socioeconomic deprivation and seasonality on polyphenol dietary intake.

Mineral supplements in Aging (2023)
Book Chapter
Welham, S., Rose, P., Coneyworth, L., Avery, A., & Kirk, C. Mineral supplements in Aging. In Biochemistry and Cell Biology of Ageing: Part V, Anti-ageing Interventions. Springer

With advancing age, achievement of dietary adequacy for all nutrients is increasingly difficult and this is particularly so for minerals. Various factors impede mineral acquisition and absorption including reduced appetite, depressed gastric acid pro... Read More about Mineral supplements in Aging.

Update on the global prevalence and severity of kiwifruit allergy: a scoping review (2023)
Journal Article
James, C. A., Welham, S., & Rose, P. (2023). Update on the global prevalence and severity of kiwifruit allergy: a scoping review. International Journal of Food Science and Technology, 58(12), 6158-6181. https://doi.org/10.1111/ijfs.16680

The production and use of kiwifruit, and their derived products, has seen rapid growth in the food industry with some 4,467,099 tonnes produced in 2021. A key area of development has been the increased use of kiwifruit waste streams to support sustai... Read More about Update on the global prevalence and severity of kiwifruit allergy: a scoping review.

The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals (2023)
Journal Article
Alsaeedi, A., Welham, S., Rose, P., & Zhu, Y.-Z. (2023). The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals. Antioxidants, 12(4), Article 908. https://doi.org/10.3390/antiox12040908

Mammalian cells and tissues have the capacity to generate hydrogen sulfide gas (H2S) via catabolic routes involving cysteine metabolism. H2S acts on cell signaling cascades that are necessary in many biochemical and physiological roles important in t... Read More about The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals.

Signaling pathways in rheumatoid arthritis: implications for targeted therapy (2023)
Journal Article
Ding, Q., Hu, W., Wang, R., Yang, Q., Zhu, M., Li, M., …Zhu, Y. Z. (2023). Signaling pathways in rheumatoid arthritis: implications for targeted therapy. Signal Transduction and Targeted Therapy, 8, Article 68. https://doi.org/10.1038/s41392-023-01331-9

Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality of life for sufferers and adds to losses in the labor force.... Read More about Signaling pathways in rheumatoid arthritis: implications for targeted therapy.

Impact of lifestyle factors on dietary vitamin B6 intake and plasma pyridoxal 5'-phosphate level in UK adults: National Diet and Nutrition Survey Rolling Programme (NDNS) (2008-2017) (2023)
Journal Article
Alsaeedi, A., Welham, S., & Rose, P. (2023). Impact of lifestyle factors on dietary vitamin B6 intake and plasma pyridoxal 5'-phosphate level in UK adults: National Diet and Nutrition Survey Rolling Programme (NDNS) (2008-2017). British Journal of Nutrition, 130(8), 1403-1415. https://doi.org/10.1017/S0007114523000417

Reduction in dietary vitamin B6 intakes is associated with increased relative risk of diseases such as cancer, atherosclerosis, and cognitive dysfunction. All forms of dietary vitamin B6 are converted to pyridoxal 5'-phosphate (PLP), that is needed f... Read More about Impact of lifestyle factors on dietary vitamin B6 intake and plasma pyridoxal 5'-phosphate level in UK adults: National Diet and Nutrition Survey Rolling Programme (NDNS) (2008-2017).

Recent updates in click and computational chemistry for drug discovery and development (2023)
Journal Article
Cai, J. H., Zhu, X. Z., Guo, P. Y., Rose, P., Liu, X. T., Liu, X., & Zhu, Y. Z. (2023). Recent updates in click and computational chemistry for drug discovery and development. Frontiers in Chemistry, 11, Article 1114970. https://doi.org/10.3389/fchem.2023.1114970

Drug discovery is a costly and time-consuming process with a very high failure rate. Recently, click chemistry and computer-aided drug design (CADD) represent popular areas for new drug development. Herein, we summarized the recent updates in click a... Read More about Recent updates in click and computational chemistry for drug discovery and development.

The Impact of the COVID-19 Pandemic on the Food Security of UK Adults Aged 20–65 Years (COVID-19 Food Security and Dietary Assessment Study) (2022)
Journal Article
Thomas, M., Eveleigh, E., Vural, Z., Rose, P., Avery, A., Coneyworth, L., & Welham, S. (2022). The Impact of the COVID-19 Pandemic on the Food Security of UK Adults Aged 20–65 Years (COVID-19 Food Security and Dietary Assessment Study). Nutrients, 14(23), Article 5078. https://doi.org/10.3390/nu14235078

The first UK lockdown greatly impacted the food security status of UK adults. This study set out to establish if food procurement was adapted differently for different income groups and if this impacted dietary intakes disproportionately. Adults (n=5... Read More about The Impact of the COVID-19 Pandemic on the Food Security of UK Adults Aged 20–65 Years (COVID-19 Food Security and Dietary Assessment Study).

Edible algae allergenicity – a short report (2022)
Journal Article
James, C. A., Welham, S., & Rose, P. (2023). Edible algae allergenicity – a short report. Journal of Applied Phycology, 35(1), 339–352. https://doi.org/10.1007/s10811-022-02880-2

The use of seaweed and algal derived products in the food industry has grown rapidly in recent times. Major areas of expansion have been in Western countries where algal derived commodities are being utilised as edible foods or sources of high value... Read More about Edible algae allergenicity – a short report.

The effect of popping, soaking, boiling and roasting processes on antinutritional factors in chickpeas and red kidney beans (2022)
Journal Article
Godrich, J., Rose, P., Muleya, M., & Gould, J. (2023). The effect of popping, soaking, boiling and roasting processes on antinutritional factors in chickpeas and red kidney beans. International Journal of Food Science and Technology, 58(1), 279-289. https://doi.org/10.1111/ijfs.16190

This study was conducted to determine the effect that a popping head (like a rice cake machine), a low-shear and low-water processing technology, has on the concentration of antinutritional factors in chickpea and red kidney beans. Seeds were popped... Read More about The effect of popping, soaking, boiling and roasting processes on antinutritional factors in chickpeas and red kidney beans.

Natural products in drug discovery and development: Synthesis and medicinal perspective of leonurine (2022)
Journal Article
Li, Z., Chen, K., Rose, P., & Zhu, Y. Z. (2022). Natural products in drug discovery and development: Synthesis and medicinal perspective of leonurine. Frontiers in Chemistry, 10, Article 1036329. https://doi.org/10.3389/fchem.2022.1036329

Natural products, those molecules derived from nature, have been used by humans for thousands of years to treat ailments and diseases. More recently, these compounds have inspired chemists to use natural products as structural templates in the develo... Read More about Natural products in drug discovery and development: Synthesis and medicinal perspective of leonurine.

HDAC4 Inhibitors as Antivascular Senescence Therapeutics (2022)
Journal Article
Huang, C., Lin, Z., Liu, X., Ding, Q., Cai, J., Zhang, Z., …Zhu, Y. Z. (2022). HDAC4 Inhibitors as Antivascular Senescence Therapeutics. Oxidative Medicine and Cellular Longevity, 2022, Article 087916. https://doi.org/10.1155/2022/3087916

Aging is an inevitable consequence of life, and during this process, the epigenetic landscape changes and reactive oxygen species (ROS) accumulation increases. Inevitably, these changes are common in many age-related diseases, including neurodegenera... Read More about HDAC4 Inhibitors as Antivascular Senescence Therapeutics.

Could consumption of yam (Dioscorea) or its extract be beneficial in controlling glycaemia: a systematic review (2021)
Journal Article
Alharazi, W., McGowen, A., Rose, P., & Jethwa, P. H. (2022). Could consumption of yam (Dioscorea) or its extract be beneficial in controlling glycaemia: a systematic review. British Journal of Nutrition, 128(4), 613-624. https://doi.org/10.1017/S0007114521003706

Yam (Dioscorea spp.) and its associated extracts have been shown to possess a variety of biological activities and identified as beneficial in the control of glycaemia in patients with Type II Diabetes Mellitus (T2DM). The objective was to conduct a... Read More about Could consumption of yam (Dioscorea) or its extract be beneficial in controlling glycaemia: a systematic review.

Hydrogen Sulfide and the Immune System (2021)
Book Chapter
Rose, P., Zhu, Y. Z., & Moore, P. K. (2021). Hydrogen Sulfide and the Immune System. In Advances in Hydrogen Sulfide Biology (99-128). Singapore: Springer. https://doi.org/10.1007/978-981-16-0991-6_5

Hydrogen sulfide (H2S) is the “third gasotransmitter” recognized alongside nitric oxide (NO) and carbon monoxide (CO). H2S exhibits an array of biological effects in mammalian cells as revealed by studies showing important roles in the cardiovascular... Read More about Hydrogen Sulfide and the Immune System.

Diet and Hydrogen Sulfide Production in Mammals (2020)
Journal Article
Rose, P., Moore, P. K., Whiteman, M., Kirk, C., & Zhu, Y.-Z. (2021). Diet and Hydrogen Sulfide Production in Mammals. Antioxidants and Redox Signaling, 34(17), 1378-1393. https://doi.org/10.1089/ars.2020.8217

Significance: In recent times, it has emerged that some dietary sulfur compounds can act on mammalian cell signaling systems via their propensity to release hydrogen sulfide (H2S). H2S plays important biochemical and physiological roles in the heart,... Read More about Diet and Hydrogen Sulfide Production in Mammals.

Epigenetics and Vascular Senescence–Potential New Therapeutic Targets? (2020)
Journal Article
Ding, Q., Shao, C., Rose, P., & Zhu, Y. Z. (2020). Epigenetics and Vascular Senescence–Potential New Therapeutic Targets?. Frontiers in Pharmacology, 11, Article 535395. https://doi.org/10.3389/fphar.2020.535395

© Copyright © 2020 Ding, Shao, Rose and Zhu. Epigenetics is defined as the heritable alterations of gene expression without changes to the coding sequence of DNA. These alterations are mediated by processes including DNA methylation, histone modifica... Read More about Epigenetics and Vascular Senescence–Potential New Therapeutic Targets?.

A novel liposomal S-propargyl-cysteine: a sustained release of hydrogen sulfide reducing myocardial fibrosis via TGF-β1/Smad pathway (2019)
Journal Article
Hieu Tran, B., Yu, Y., Chang, L., Tan, B., Jia, W., Xiong, Y., …Zhun Zhu, Y. (2019). A novel liposomal S-propargyl-cysteine: a sustained release of hydrogen sulfide reducing myocardial fibrosis via TGF-β1/Smad pathway. International Journal of Nanomedicine, 2019:14, 10061-10077. https://doi.org/10.2147/IJN.S216667

Purpose: S-propargyl-cysteine (SPRC; alternatively known as ZYZ-802) is a novel modulator of endogenous tissue H2S concentrations with known cardioprotective and anti-inflammatory effects. However, its rapid metabolism and excretion have limited its... Read More about A novel liposomal S-propargyl-cysteine: a sustained release of hydrogen sulfide reducing myocardial fibrosis via TGF-β1/Smad pathway.