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Natural products in drug discovery and development: Synthesis and medicinal perspective of leonurine

Li, Zhaoyi; Chen, Keyuan; Rose, Peter; Zhu, Yi Zhun

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Authors

Zhaoyi Li

Keyuan Chen

PETER ROSE Peter.Rose@nottingham.ac.uk
Assistant Professor

Yi Zhun Zhu



Abstract

Natural products, those molecules derived from nature, have been used by humans for thousands of years to treat ailments and diseases. More recently, these compounds have inspired chemists to use natural products as structural templates in the development of new drug molecules. One such compound is leonurine, a molecule isolated and characterized in the tissues of Herb leonuri. This molecule has received attention from scientists in recent years due to its potent anti-oxidant, anti-apoptotic, and anti-inflammatory properties. More recently researchers have shown leonurine to be useful in the treatment of cardiovascular and nervous system diseases. Like other natural products such as paclitaxel and artemisinin, the historical development of leonurine as a therapeutic is very interesting. Therefore, this review provided an overview of natural product discovery, through to the development of a potential new drug. Content will summarize known plant sources, the pathway used in the synthesis of leonurine, and descriptions of leonurine’s pharmacological properties in mammalian systems.

Citation

Li, Z., Chen, K., Rose, P., & Zhu, Y. Z. (2022). Natural products in drug discovery and development: Synthesis and medicinal perspective of leonurine. Frontiers in Chemistry, 10, Article 1036329. https://doi.org/10.3389/fchem.2022.1036329

Journal Article Type Article
Acceptance Date Oct 5, 2022
Online Publication Date Oct 17, 2022
Publication Date Oct 17, 2022
Deposit Date Nov 16, 2022
Publicly Available Date Nov 17, 2022
Journal Frontiers in Chemistry
Electronic ISSN 2296-2646
Publisher Frontiers Media SA
Peer Reviewed Peer Reviewed
Volume 10
Article Number 1036329
DOI https://doi.org/10.3389/fchem.2022.1036329
Keywords Chemistry, herb leonuri, leonurine, synthesis, pharmacological effects, cardiovascular diseases, nervous system diseases
Public URL https://nottingham-repository.worktribe.com/output/13449770
Publisher URL https://www.frontiersin.org/articles/10.3389/fchem.2022.1036329/full

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