Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Ding, Qian; Hu, Wei; Wang, Ran; Yang, Qinyan; Zhu, Menglin; Li, Meng; Cai, Jianghong; Rose, Peter; Mao, Jianchun; Zhu, Yi Zhun

Abstract

Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality of life for sufferers and adds to losses in the labor force. In the past few decades, RA has attracted increased attention from researchers, the abnormal signaling pathways in RA are a very important research field in the diagnosis and treatment of RA, which provides important evidence for understanding this complex disease and developing novel RA-linked intervention targets. The current review intends to provide a comprehensive overview of RA, including a general introduction to the disease, historical events, epidemiology, risk factors, and pathological process, highlight the primary research progress of the disease and various signaling pathways and molecular mechanisms, including genetic factors, epigenetic factors, summarize the most recent developments in identifying novel signaling pathways in RA and new inhibitors for treating RA. therapeutic interventions including approved drugs, clinical drugs, pre-clinical drugs, and cutting-edge therapeutic technologies. These developments will hopefully drive progress in new strategically targeted therapies and hope to provide novel ideas for RA treatment options in the future.

Citation

Ding, Q., Hu, W., Wang, R., Yang, Q., Zhu, M., Li, M., …Zhu, Y. Z. (2023). Signaling pathways in rheumatoid arthritis: implications for targeted therapy. Signal Transduction and Targeted Therapy, 8, Article 68. https://doi.org/10.1038/s41392-023-01331-9

• Journal Article Type: Article
• Acceptance Date: Jan 18, 2023
• Online Publication Date: Feb 17, 2023
• Publication Date: Feb 17, 2023
• Deposit Date: Nov 8, 2023
• Publicly Available Date: Nov 9, 2023
• Journal: Signal Transduction and Targeted Therapy
• Electronic ISSN: 2059-3635
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Article Number: 68
• DOI: https://doi.org/10.1038/s41392-023-01331-9
• Public URL: https://nottingham-repository.worktribe.com/output/17651970
• Publisher URL: https://www.nature.com/articles/s41392-023-01331-9