The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals

Alsaeedi, Asrar; Welham, Simon; Rose, Peter; Zhu, Yi-Zhun

Abstract

Mammalian cells and tissues have the capacity to generate hydrogen sulfide gas (H2S) via catabolic routes involving cysteine metabolism. H2S acts on cell signaling cascades that are necessary in many biochemical and physiological roles important in the heart, brain, liver, kidney, urogenital tract, and cardiovascular and immune systems of mammals. Diminished levels of this molecule are observed in several pathophysiological conditions including heart disease, diabetes, obesity, and immune function. Interestingly, in the last two decades, it has become apparent that some commonly prescribed pharmacological drugs can impact the expression and activities of enzymes responsible for hydrogen sulfide production in cells and tissues. Therefore, the current review provides an overview of the studies that catalogue key drugs and their impact on hydrogen sulfide production in mammals.

Citation

Alsaeedi, A., Welham, S., Rose, P., & Zhu, Y.-Z. (2023). The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals. Antioxidants, 12(4), Article 908. https://doi.org/10.3390/antiox12040908

• Journal Article Type: Article
• Acceptance Date: Apr 9, 2023
• Online Publication Date: Apr 11, 2023
• Publication Date: 2023-04
• Deposit Date: Nov 8, 2023
• Publicly Available Date: Nov 8, 2023
• Journal: Antioxidants
• Electronic ISSN: 2076-3921
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 4
• Article Number: 908
• DOI: https://doi.org/10.3390/antiox12040908
• Keywords: Cell Biology, Clinical Biochemistry, Molecular Biology, Biochemistry, Physiology
• Public URL: https://nottingham-repository.worktribe.com/output/19993386
• Publisher URL: https://www.mdpi.com/2076-3921/12/4/908