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Recent updates in click and computational chemistry for drug discovery and development

Cai, Jiang Hong; Zhu, Xuan Zhe; Guo, Peng Yue; Rose, Peter; Liu, Xiao Tong; Liu, Xia; Zhu, Yi Zhun

Authors

Jiang Hong Cai

Xuan Zhe Zhu

Peng Yue Guo

Xiao Tong Liu

Xia Liu

Yi Zhun Zhu



Abstract

Drug discovery is a costly and time-consuming process with a very high failure rate. Recently, click chemistry and computer-aided drug design (CADD) represent popular areas for new drug development. Herein, we summarized the recent updates in click and computational chemistry for drug discovery and development including clicking to effectively synthesize druggable candidates, synthesis and modification of natural products, targeted delivery systems, and computer-aided drug discovery for target identification, seeking out and optimizing lead compounds, ADMET prediction as well as compounds synthesis, hopefully, inspires new ideas for novel drug development in the future.

Citation

Cai, J. H., Zhu, X. Z., Guo, P. Y., Rose, P., Liu, X. T., Liu, X., & Zhu, Y. Z. (2023). Recent updates in click and computational chemistry for drug discovery and development. Frontiers in Chemistry, 11, Article 1114970. https://doi.org/10.3389/fchem.2023.1114970

Journal Article Type Article
Acceptance Date Jan 27, 2023
Online Publication Date Feb 7, 2023
Publication Date Feb 7, 2023
Deposit Date Nov 8, 2023
Publicly Available Date Nov 9, 2023
Journal Frontiers in Chemistry
Electronic ISSN 2296-2646
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 11
Article Number 1114970
DOI https://doi.org/10.3389/fchem.2023.1114970
Keywords Chemistry, click chemistry, computational chemistry, CADD, druggable candidates, drug development
Public URL https://nottingham-repository.worktribe.com/output/17934229
Publisher URL https://www.frontiersin.org/articles/10.3389/fchem.2023.1114970/full

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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.





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