Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis

Mu, Guohao; Peng, Fang; Zhang, Ziyin; M. Brameld, John; Rose, Peter; Yang, Xiaogang; Jiang, Zhi-jiang; He, Xi; Tang, Bencan

Abstract

This study designed and developed a novel three-layer electrostatic, slow-releasing nanoparticle drug delivery system for the treatment of ulcerative colitis. The nanoparticles were composed of layers of zein-based polydopamine, chitosan and cellulose acetate phthalate to form a polyelectrolyte multilayer core−shell nanoparticle structure. The anti-inflammatory natural product magnolol was chosen to be the model drug for the study. The nanoparticles (260.50 ± 23.90 nm) were prepared with layer-by-layer coating and then assessed in vitro and in vivo using a mouse model of ulcerative colitis. The in vitro data confirmed the slow-releasing and pH-dependent characteristics of particles. Quantitative analysis of the in vivo distribution of Mag in mice showed significantly higher concentrations in colonic tissue than in the upper gastrointestinal tract (854.6 ng/g vs 291.5–351.1 ng/g, respectively). Histological and pro-inflammatory cytokine analysis indicated that the nanoparticles had a significant anti-inflammatory effect and were protective against DSS-induced structural damage of the colonic mucosal structure. These results confirm that this nano-delivery system could increase the levels of Mag reaching the colon, resulting in greater efficacy than free Mag in treating UC in this mouse model.

Citation

Mu, G., Peng, F., Zhang, Z., M. Brameld, J., Rose, P., Yang, X., Jiang, Z.-J., He, X., & Tang, B. (2024). Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis. Journal of Drug Delivery Science and Technology, 101(Part A), Article 106151. https://doi.org/10.1016/j.jddst.2024.106151

• Journal Article Type: Article
• Acceptance Date: Sep 2, 2024
• Online Publication Date: Sep 6, 2024
• Publication Date: 2024-11
• Deposit Date: Sep 16, 2024
• Publicly Available Date: Sep 7, 2025
• Journal: Journal of Drug Delivery Science and Technology
• Print ISSN: 1773-2247
• Electronic ISSN: 1773-2247
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 101
• Issue: Part A
• Article Number: 106151
• DOI: https://doi.org/10.1016/j.jddst.2024.106151
• Public URL: https://nottingham-repository.worktribe.com/output/39176264
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S1773224724008207?via%3Dihub