All Outputs (17)

Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT (2022)
Journal Article

Background Freezing all embryos, followed by thawing and transferring them into the uterine cavity at a later stage (freeze-all), instead of fresh-embryo transfer may lead to improved pregnancy rates and fewer complications during in vitro fertilisa... Read More about Transfer of thawed frozen embryo versus fresh embryo to improve the healthy baby rate in women undergoing IVF: the E-Freeze RCT.

Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze) (2022)
Journal Article

STUDY QUESTION: Does a policy of elective freezing of embryos, followed by frozen embryo transfer result in a higher healthy baby rate, after first embryo transfer, when compared with the current policy of transferring fresh embryos? SUMMARY ANSWER:... Read More about Elective freezing of embryos versus fresh embryo transfer in IVF: a multicentre randomized controlled trial in the UK (E-Freeze).

Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure (2020)
Journal Article

Research question What is the difference in endometrial transcriptomics between women with normal and with low mid-luteal progesterone during the implantation window? Design An endometrial biopsy and serum progesterone concentration were taken f... Read More about Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure.

Evaluation of progestogen supplementation for luteal phase support in fresh in vitro fertilization cycles (2019)
Journal Article

© 2019 American Society for Reproductive Medicine Objective: To evaluate the effectiveness of progestogen supplementation in improving clinical pregnancy rates in women undergoing fresh IVF cycles and to compare different routes, start times, duratio... Read More about Evaluation of progestogen supplementation for luteal phase support in fresh in vitro fertilization cycles.

Levothyroxine in women with thyroid peroxidase antibodies before conception (2019)
Journal Article

Background Thyroid peroxidase antibodies are associated with an increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate that the use of levothyroxine could reduce the incidence of such adverse out... Read More about Levothyroxine in women with thyroid peroxidase antibodies before conception.

Efficacy of dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): a proof of principle double blinded randomized placebo controlled trial (2017)
Journal Article

Objective: To evaluate the effect of DHEA supplementation on In-Vitro Fertilisation (IVF) outcome as assessed by ovarian response, oocyte developmental competence and live birth rates in women predicted to have poor ovarian reserve (OR). The feasibil... Read More about Efficacy of dehydroepiandrosterone (DHEA) to overcome the effect of ovarian ageing (DITTO): a proof of principle double blinded randomized placebo controlled trial.

Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology (2017)
Journal Article

Objectives: To identify and prioritise important research questions for miscarriage. Design: A priority setting partnership using prospective surveys and consensus meetings following methods advocated by the James Lind Alliance. Setting: United Kin... Read More about Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology.

Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF (2016)
Journal Article

Evidence for an association between cortisol and clinical pregnancy in women undergoing In Vitro Fertilisation (IVF) is mixed with previous studies relying exclusively on short term measures of cortisol in blood, saliva, urine, and/or follicular flui... Read More about Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF.

Anxiety associated with diagnostic uncertainties in early pregnancy. (2016)
Journal Article

Objectives: To determine anxiety levels of women presenting to Early Pregnancy Assessment Units (EPAU) with abdominal pain and/or vaginal bleeding and assess how these change over time and according to ultrasonographic diagnosis. Methods: We under... Read More about Anxiety associated with diagnostic uncertainties in early pregnancy..

Maternal and neonatal outcomes in pregnant women with PCOS: comparison of different diagnostic definitions (2015)
Journal Article

A clinically useful simplified blastocyst grading system (2015)
Journal Article

Surgical intervention versus expectant management for endometrial polyps in subfertile women (2014)
Journal Article

BACKGROUND: Endometrial polyps, which are benign growths of the endometrium, may be a factor in female subfertility. Possible mechanisms include physical interference with gamete transport, alteration of the endometrial milieu and unresponsiveness t... Read More about Surgical intervention versus expectant management for endometrial polyps in subfertile women.

Lipidomic analysis of plasma samples from women with polycystic ovary syndrome (2014)
Journal Article

Abstract Polycystic ovary syndrome (PCOS) is a common disorder affecting between 5 and 18 % of females of reproductive age and can be diagnosed based on a combination of clinical, ultrasound and biochemical features, none of which on its own is diagn... Read More about Lipidomic analysis of plasma samples from women with polycystic ovary syndrome.

Heparin for assisted reproduction (Review) (2013)
Journal Article

Abstract BACKGROUND: Heparin as an adjunct in assisted reproduction (peri-implantation heparin) is given at or after egg collection or at embryo transfer during assisted reproduction. Heparin has been advocated to improve embryo implantation and cl... Read More about Heparin for assisted reproduction (Review).

Maternal smoking during pregnancy and fetal organ growth: a magnetic resonance imaging study (2013)
Journal Article

Objective: To study whether maternal cigarette smoking during pregnancy is associated with alterations in the growth of fetal lungs, kidneys, liver, brain, and placenta. Design: A case-control study, with operators performing the image analysis bli... Read More about Maternal smoking during pregnancy and fetal organ growth: a magnetic resonance imaging study.

User requirements for the development of smartphone self-reporting applications in healthcare (2013)
Conference Proceeding

Two case studies of the development of Smartphone self-reporting mHealth applications are described: a wellness diary for asthma management combined with Bluetooth pulse oximeter and manual peak flow measurements; and a questionnaire for ecological a... Read More about User requirements for the development of smartphone self-reporting applications in healthcare.

Native Apps versus Web Apps: which is best for healthcare applications? (2013)
Journal Article

Smartphone applications (Apps) provide a new way to deliver healthcare, illustrated by the fact that healthcare Apps are estimated to make up over 30% of new Apps currently being developed; with this number seemingly set to increase as the benefits b... Read More about Native Apps versus Web Apps: which is best for healthcare applications?.