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Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology

Prior, Matthew; Bagness, Carmel; Brewin, Jane; Coomarasamy, Arri; Easthope, Lucy; Hepworth-Jones, Barbara; Hinshaw, Kim; O'Toole, Emily; Orford, Julie; Regan, Lesley; Raine-Fenning, Nick; Shakespeare, Judy; Small, Rachel; Thornton, Jim; Metcalf, Leanne

Authors

Matthew Prior

Carmel Bagness

Jane Brewin

Arri Coomarasamy

Lucy Easthope

Barbara Hepworth-Jones

Kim Hinshaw

Emily O'Toole

Julie Orford

Lesley Regan

Nick Raine-Fenning

Judy Shakespeare

Rachel Small

Jim Thornton

Leanne Metcalf



Abstract

Objectives: To identify and prioritise important research questions for miscarriage.
Design: A priority setting partnership using prospective surveys and consensus meetings following methods advocated by the James Lind Alliance.
Setting: United Kingdom
Participants: Women and those affected by miscarriage working alongside healthcare professionals.
Results: In the initial survey, 1093 participants (932 women who have experienced miscarriage, 8 partners, 17 family members, friends or colleagues, 104 HCPs and 8 charitable organisations) submitted 3279 questions. A review of existing literature identified a further 64. Non-questions were removed and the remaining questions were categorised and summarised into 58 questions. In an interim electronic survey 2122 respondents chose their top ten priorities from the 58 summary questions. The 25 highest ranked in the survey were prioritised at a final face-to-face workshop. In summary, the top ten priorities were ranked as follows: research into preventative treatment, emotional aspects in general, investigation, relevance of pre-existing medical conditions, emotional support as a treatment, importance of lifestyle factors, importance of genetic and chromosomal causes, preconception tests, investigation after different numbers of miscarriage and male causal factors.
Conclusions: These results should be the focus of future miscarriage research. Presently, studies are being conducted to address the top priority, however many other priorities, especially psychological and emotional support are less well researched areas. We hope our results will encourage both researchers and funders to focus on these priorities.

Journal Article Type Article
Publication Date Aug 1, 2017
Journal BMJ Open
Electronic ISSN 2044-6055
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 7
Article Number e016571
APA6 Citation Prior, M., Bagness, C., Brewin, J., Coomarasamy, A., Easthope, L., Hepworth-Jones, B., …Metcalf, L. (2017). Priorities for research in miscarriage: a priority setting partnership between people affected by miscarriage and professionals, following the James Lind Alliance methodology. BMJ Open, 7, https://doi.org/10.1136/bmjopen-2017-016571
DOI https://doi.org/10.1136/bmjopen-2017-016571
Keywords Reproductive medicine, Qualitative research, Statistics & research methods, Ultrasound, Depression & mood disorders
Publisher URL http://bmjopen.bmj.com/content/7/8/e016571.full
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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