All Outputs (12)

Programmable Deuteration of Indoles via Reverse Deuterium Exchange (2023)
Journal Article

Methods for selective deuterium incorporation into drug-like molecules have become extremely valuable due to the commercial, mechanistic, and biological importance of deuterated compounds. Herein, we report a programmable labeling platform that allow... Read More about Programmable Deuteration of Indoles via Reverse Deuterium Exchange.

Frontispiece: A Guide to Directing Group Removal: 8‐Aminoquinoline (2021)
Journal Article

A Guide to Directing Group Removal: 8?Aminoquinoline (2021)
Journal Article

The use of directing groups allows high levels of selectivity to be achieved in transition metal‐catalyzed transformations. Efficient removal of these auxiliaries after successful functionalization, however, can be very challenging. This review provi... Read More about A Guide to Directing Group Removal: 8?Aminoquinoline.

Controlling the crystal structure of precisely spaced polyethylene-like polyphosphoesters (2020)
Journal Article

Understanding polymer crystallization is important for polyethylene-like materials. A small fraction of monomers with functional groups within the polyethylene chain can act as crystallization “defects”. Such defects can be used to control the crysta... Read More about Controlling the crystal structure of precisely spaced polyethylene-like polyphosphoesters.

Protodepalladation as a Strategic Elementary Step in Catalysis (2018)
Journal Article

Protodepalladation is the redox-neutral conversion of a C–Pd(II) bond into a C–H bond via reaction with a Brønsted acid. It is the microscopic reverse of Pd(II)-mediated C–H cleavage. In the context of catalytic reaction development, protodepalladati... Read More about Protodepalladation as a Strategic Elementary Step in Catalysis.

ChemInform Abstract: Cross-Coupling of [2-Aryl-1,1,2,2-Tetrafluoroethyl](trimethyl)silanes with Aryl Halides. (2015)
Journal Article

No abstract is available for this article.

Cross-Coupling of [2-Aryl-1,1,2,2-tetrafluoroethyl](trimethyl)silanes with Aryl Halides (2015)
Journal Article

The synthesis of arylCF2CF2SiMe3 and their reactivity in cross-coupling reactions with aryl iodides and aryl bromides to afford a range of 1,1,2,2-tetrafluoro-1,2-arylethanes is reported. The use of pyridine as an alternative to phenanthroline, and t... Read More about Cross-Coupling of [2-Aryl-1,1,2,2-tetrafluoroethyl](trimethyl)silanes with Aryl Halides.

Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas (2015)
Journal Article

Perfluorohexane gas when introduced in the air atmosphere above a film of phospholipid self-supported on an aqueous solution of C2F5-labeled compounds causes the recruitment and immobilization of the latter in the interfacial film. When the phospholi... Read More about Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas.

ChemInform Abstract: Catalytic Hydrotrifluoromethylation of Unactivated Alkenes (2013)
Journal Article

Catalytic Decarboxylative Fluorination for the Synthesis of Tri- and Difluoromethyl Arenes (2013)
Journal Article

Treatment of readily available α,α-difluoro- and α-fluoroarylacetic acids with Selectfluor under Ag(I) catalysis led to decarboxylative fluorination. This operationally simple reaction gave access to tri- and difluoromethylarenes applying a late-stag... Read More about Catalytic Decarboxylative Fluorination for the Synthesis of Tri- and Difluoromethyl Arenes.

Trifluoromethylation of Allylsilanes under Photoredox Catalysis (2013)
Journal Article

A new catalytic method to access allylic secondary CF3 products is described. These reactions use the visible light excited Ru(bpy)3Cl2·6H2O catalyst and the Togni or Umemoto reagent as the CF3 source. The photoredox catalytic manifold delivers enant... Read More about Trifluoromethylation of Allylsilanes under Photoredox Catalysis.

Catalytic Hydrotrifluoromethylation of Unactivated Alkenes (2013)
Journal Article

A visible-light-mediated hydrotrifluoromethylation of unactivated alkenes that uses the Umemoto reagent as the CF3 source and MeOH as the reductant is disclosed. This effective transformation operates at room temperature in the presence of 5 mol % Ru... Read More about Catalytic Hydrotrifluoromethylation of Unactivated Alkenes.