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Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas

Yang, Guang; O'Duill, Miriam; Gouverneur, Véronique; Krafft, Marie Pierre

Authors

Guang Yang

Profile image of MIRIAM O'DUILL

MIRIAM O'DUILL MIRIAM.ODUILL@NOTTINGHAM.AC.UK
Assistant Professor in Chemistry

Véronique Gouverneur

Marie Pierre Krafft



Abstract

Perfluorohexane gas when introduced in the air atmosphere above a film of phospholipid self-supported on an aqueous solution of C2F5-labeled compounds causes the recruitment and immobilization of the latter in the interfacial film. When the phospholipid forms a liquid-condensed Gibbs monolayer, which is the case for dipalmitoylphosphatidylcholine (DPPC), the C2F5-labeled molecule remains trapped in the monolayer after removal of F-hexane. Investigations involve bubble profile analysis tensiometry (Gibbs films), Langmuir monolayers and microbubble experiments. The new phenomenon was utilized to incorporate a hypoxia biomarker, a C2F5-labeled nitrosoimidazole (EF5), in microbubble shells. This finding opens perspectives in the delivery of fluorinated therapeutic molecules and biomarkers.

Citation

Yang, G., O'Duill, M., Gouverneur, V., & Krafft, M. P. (2015). Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas. Angewandte Chemie, 127(29), 8522-8526. https://doi.org/10.1002/ange.201502677

Journal Article Type Article
Online Publication Date Jun 9, 2015
Publication Date Jul 13, 2015
Deposit Date Jul 31, 2023
Journal Angewandte Chemie
Print ISSN 0044-8249
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 127
Issue 29
Pages 8522-8526
DOI https://doi.org/10.1002/ange.201502677
Public URL https://nottingham-repository.worktribe.com/output/23554243
Publisher URL https://onlinelibrary.wiley.com/doi/10.1002/ange.201502677
Additional Information Zuschrift