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Protodepalladation as a Strategic Elementary Step in Catalysis

Engle, Keary; O�Duill, Miriam

Authors

Keary Engle

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MIRIAM O'DUILL MIRIAM.ODUILL@NOTTINGHAM.AC.UK
Assistant Professor in Chemistry



Abstract

Protodepalladation is the redox-neutral conversion of a C–Pd(II) bond into a C–H bond via reaction with a Brønsted acid. It is the microscopic reverse of Pd(II)-mediated C–H cleavage. In the context of catalytic reaction development, protodepalladation offers a means of converting organopalladium(II) intermediates into organic products without a change in oxidation state at the metal center. Hence, when integrated into catalytic cycles, it can be a uniquely enabling elementary step. The goal of this review is to provide an overview of protodepalladation, including exploration of different reaction types, discussion of literature examples, and analysis of mechanistic features. Our hope is that this review will stimulate other researchers in the field to pursue new applications of this underexploited step in catalysis.

Citation

Engle, K., & O’Duill, M. (2018). Protodepalladation as a Strategic Elementary Step in Catalysis. SYNTHESIS, 50(24), 4699-4714. https://doi.org/10.1055/s-0037-1611064

Journal Article Type Article
Acceptance Date Sep 19, 2018
Online Publication Date Oct 29, 2018
Publication Date 2018-12
Deposit Date Apr 12, 2021
Journal Synthesis
Print ISSN 0039-7881
Electronic ISSN 1437-210X
Publisher Thieme Publishing
Peer Reviewed Peer Reviewed
Volume 50
Issue 24
Pages 4699-4714
DOI https://doi.org/10.1055/s-0037-1611064
Keywords Organic Chemistry; Catalysis
Public URL https://nottingham-repository.worktribe.com/output/4847307
Publisher URL https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0037-1611064