Catalytic Hydrotrifluoromethylation of Unactivated Alkenes

Mizuta, Satoshi; Verhoog, Stefan; Engle, Keary M.; Khotavivattana, Tanatorn; O’Duill, Miriam; Wheelhouse, Katherine; Rassias, Gerasimos; Médebielle, Maurice; Gouverneur, Véronique

Abstract

A visible-light-mediated hydrotrifluoromethylation of unactivated alkenes that uses the Umemoto reagent as the CF3 source and MeOH as the reductant is disclosed. This effective transformation operates at room temperature in the presence of 5 mol % Ru(bpy)3Cl2; the process is characterized by its operational simplicity and functional group tolerance.

Citation

Mizuta, S., Verhoog, S., Engle, K. M., Khotavivattana, T., O’Duill, M., Wheelhouse, K., Rassias, G., Médebielle, M., & Gouverneur, V. (2013). Catalytic Hydrotrifluoromethylation of Unactivated Alkenes. Journal of the American Chemical Society, 135(7), 2505–2508. https://doi.org/10.1021/ja401022x

• Journal Article Type: Article
• Online Publication Date: Feb 7, 2013
• Publication Date: Feb 20, 2013
• Deposit Date: Jul 31, 2023
• Journal: Journal of the American Chemical Society
• Print ISSN: 0002-7863
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 135
• Issue: 7
• Pages: 2505–2508
• DOI: https://doi.org/10.1021/ja401022x
• Public URL: https://nottingham-repository.worktribe.com/output/23554284
• Publisher URL: https://pubs.acs.org/doi/10.1021/ja401022x