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All Outputs (43)

Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes (2020)
Journal Article

Recent large genome-wide association studies (GWAS) have independently identified a set of genetic loci associated with lean body mass (LBM) and handgrip strength (HGS). Evaluation of these candidate single nucleotide polymorphisms (SNPs) may be usef... Read More about Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes.

Relationship of anabolic hormones with motor unit characteristics in quadriceps muscle in healthy and frail ageing men (2020)
Journal Article

Context Anabolic hormones are important factors in maintaining muscle mass for ageing men, but their role in overall motor unit structure and function is unclear. Objective To determine associations of anabolic and reproductive hormone levels wi... Read More about Relationship of anabolic hormones with motor unit characteristics in quadriceps muscle in healthy and frail ageing men.

Comparison of Muscle Function, Bone Mineral Density and Body Composition of Early Starting and Later Starting Older Masters Athletes (2019)
Journal Article

© 2019 Piasecki, Ireland, Piasecki, Deere, Hannam, Tobias and McPhee. Masters endurance runners can epitomize healthy aging; being reflective of the physiological processes of aging without the compounded effects of inactivity. The primary aim of the... Read More about Comparison of Muscle Function, Bone Mineral Density and Body Composition of Early Starting and Later Starting Older Masters Athletes.

Long-Term Endurance and Power Training May Facilitate Motor Unit Size Expansion to Compensate for Declining Motor Unit Numbers in Older Age (2019)
Journal Article

© 2019 Frontiers Media S.A. All Rights Reserved. The evidence concerning the effects of exercise in older age on motor unit (MU) numbers, muscle fiber denervation and reinnervation cycles is inconclusive and it remains unknown whether any effects are... Read More about Long-Term Endurance and Power Training May Facilitate Motor Unit Size Expansion to Compensate for Declining Motor Unit Numbers in Older Age.

Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly (2018)
Journal Article

The key objective of this work was to investigate the impact of young and old human lymphocyte secretomes on C2C12 myoblasts regeneration. Conditioned media (CMs) were harvested from isolated young and older lymphocytes treated with (activated AC), o... Read More about Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly.

The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans (2018)
Journal Article

Age-related loss of skeletal muscle mass and function, sarcopenia, is associated with physical frailty and increased risk of morbidity (chronic diseases), in addition to all-cause mortality. The loss of muscle mass occurs incipiently from middle-age... Read More about The age-related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans.

Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls (2018)
Journal Article

Summary: We examined bone density in older athletes and controls. Sprinters had greater hip and spine bone density than endurance athletes and controls, whereas values were similar in the latter two groups. These results could not be explained by dif... Read More about Hip and spine bone mineral density are greater in master sprinters, but not endurance runners compared with non-athletic controls.

Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men (2018)
Journal Article

Sarcopenia results from the progressive loss of skeletal muscle mass and reduced function in older age. It is likely to be associated with the well‐documented reduction of motor unit numbers innervating limb muscles and the increase in size of surviv... Read More about Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men.

The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia (2018)
Journal Article

The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia remain unclear. To investigate, 40 older (20 women; age 72 ± 4 years) and 31 younger adults (15 women, age 22 ± 3 years) comple... Read More about The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia.

The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners (2018)
Journal Article

Regular intense endurance exercise can lead to amenorrhea with possible adverse consequences for bone health. We compared whole body and regional bone strength and skeletal muscle characteristics between amenorrheic (AA: n = 14) and eumenorrheic (EA:... Read More about The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners.

The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles (2018)
Journal Article

Purpose Current methods for estimating muscle motor unit (MU) number provide values which are remarkably similar for muscles of widely differing size, probably because surface electrodes sample from similar and relatively small volumes in each mus... Read More about The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles.

Motor unit number estimates and neuromuscular transmission in the tibialis anterior of master athletes: evidence that athletic older people are not spared from age-related motor unit remodeling (2016)
Journal Article

Muscle motor unit numbers decrease markedly in old age, while remaining motor units are enlarged and can have reduced neuromuscular junction transmission stability. However, it is possible that regular intense physical activity throughout life can at... Read More about Motor unit number estimates and neuromuscular transmission in the tibialis anterior of master athletes: evidence that athletic older people are not spared from age-related motor unit remodeling.