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All Outputs (25)

Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy (2022)
Journal Article

Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD), a common muscle disease that manifests with muscle weakness, wasting, and degeneration. An emerging theme in DMD pathophysiology is an intramuscular deficit in the gasotransmit... Read More about Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy.

Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability (2022)
Journal Article

New Findings: What is the central question of this study? Can bilateral knee extensor force accuracy be improved following 4 weeks of unilateral force accuracy training and are there any subsequent alterations to central and/or peripheral motor unit... Read More about Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability.

Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men (2021)
Journal Article

Long-term exercise training has been considered as an effective strategy to counteract age-related hormonal declines and minimise muscle atrophy. However, human data relating circulating hormone levels with motor nerve function are scant. The aims of... Read More about Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men.

Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy (2021)
Journal Article

Objective: Disuse atrophy (DA) describes inactivity-induced skeletal muscle loss, through incompletely defined mechanisms. An intriguing observation is that individual muscles exhibit differing degrees of atrophy, despite exhibiting similar anatomica... Read More about Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy.

Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis (2021)
Journal Article

Motor unit (MU) expansion enables rescue of denervated muscle fibres helping to ameliorate age-relatedmuscle atrophy, with evidence to suggest master athletes are more successful at this remodelling. Electrophysiological data has suggested MUs locate... Read More about Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis.

Factors associated with electrical stimulation?induced performance fatigability are dependent upon stimulation location (2021)
Journal Article

Neuromuscular electrical stimulation (NMES) is increasingly viewed as a central tenet to minimise muscle loss during periods of disuse/illness – typically applied directly over a muscle belly. Peripheral nerve stimulation (PNS) is afforded less atten... Read More about Factors associated with electrical stimulation?induced performance fatigability are dependent upon stimulation location.

Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model (2021)
Journal Article

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and weakness due to mutations in the dystrophin gene. The symptoms of DMD share similarities with those of accelerated aging. Recentl... Read More about Mitochondrial hydrogen sulfide supplementation improves health in the C. elegans Duchenne muscular dystrophy model.

Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle (2020)
Journal Article

One of the most notable effects of ageing is an accelerated decline of skeletal muscle mass and function, resulting in various undesirable outcomes such as falls, frailty, and all-cause mortality. The loss of muscle mass directly leads to functional... Read More about Molecular and neural adaptations to neuromuscular electrical stimulation; Implications for ageing muscle.

Influence of sex on the age?related adaptations of neuromuscular function and motor unit properties in elite masters athletes (2020)
Journal Article

Motor unit (MU) remodelling acts to minimise loss of muscle fibres following denervation in older age, which may be more successful in masters athletes. Evidence suggests performance and neuromuscular function decline with age in this population, alt... Read More about Influence of sex on the age?related adaptations of neuromuscular function and motor unit properties in elite masters athletes.

Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes (2020)
Journal Article

Recent large genome-wide association studies (GWAS) have independently identified a set of genetic loci associated with lean body mass (LBM) and handgrip strength (HGS). Evaluation of these candidate single nucleotide polymorphisms (SNPs) may be usef... Read More about Targeted genotype analyses of GWAS-derived lean body mass and handgrip strength-associated single nucleotide polymorphisms in elite masters athletes.

Comparison of Muscle Function, Bone Mineral Density and Body Composition of Early Starting and Later Starting Older Masters Athletes (2019)
Journal Article

© 2019 Piasecki, Ireland, Piasecki, Deere, Hannam, Tobias and McPhee. Masters endurance runners can epitomize healthy aging; being reflective of the physiological processes of aging without the compounded effects of inactivity. The primary aim of the... Read More about Comparison of Muscle Function, Bone Mineral Density and Body Composition of Early Starting and Later Starting Older Masters Athletes.