Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability

Ely, Isabel A.; Jones, Eleanor J.; Inns, Thomas B.; Dooley, Síobhra; Miller, Sarah B. J.; Stashuk, Daniel W.; Atherton, Philip J.; Phillips, Bethan E.; Piasecki, Mathew

Abstract

New Findings: What is the central question of this study? Can bilateral knee extensor force accuracy be improved following 4 weeks of unilateral force accuracy training and are there any subsequent alterations to central and/or peripheral motor unit features? What is the main finding and its importance? In the trained limb only, knee extensor force tracking accuracy improved with reduced motor unit firing rate variability in the vastus lateralis, and there was no change to neuromuscular junction transmission instability. Interventional strategies to improve force accuracy may be directed to older/clinical populations where such improvements may aid performance of daily living activities. Abstract: Muscle force output during sustained submaximal isometric contractions fluctuates around an average value and is partly influenced by variation in motor unit (MU) firing rates. MU firing rate (FR) variability seemingly reduces following exercise training interventions; however, much less is known with respect to peripheral MU properties. We therefore investigated whether targeted force accuracy training could lead to improved muscle functional capacity and control, in addition to determining any alterations of individual MU features. Ten healthy participants (seven females, three males, 27±6 years, 170±8cm, 69±16kg) underwent a 4-week supervised, unilateral knee extensor force accuracy training intervention. The coefficient of variation for force (FORCECoV) and sinusoidal wave force tracking accuracy (FORCESinu) were determined at 25% maximal voluntary contraction (MVC) pre- and post-training. Intramuscular electromyography was utilised to record individual MU potentials from the vastus lateralis (VL) muscles at 25% MVC during sustained contractions, pre- and post-training. Knee extensor muscle strength remained unchanged following training, with no improvements in unilateral leg-balance. FORCECoV and FORCESinu significantly improved in only the trained knee extensors by ∼13% (P =0.01) and ∼30% (P <0.0001), respectively. MU FR variability significantly reduced in the trained VL by ∼16% (n =8; P= 0.001), with no further alterations to MU FR or neuromuscular junction transmission instability. Our results suggest muscle force control and tracking accuracy is a trainable characteristic in the knee extensors, which is likely explained by the reduction in MU FR variability which was apparent in the trained limb only.

Citation

Ely, I. A., Jones, E. J., Inns, T. B., Dooley, S., Miller, S. B. J., Stashuk, D. W., …Piasecki, M. (2022). Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability. Experimental Physiology, https://doi.org/10.1113/EP090367

• Journal Article Type: Article
• Acceptance Date: Jul 28, 2022
• Online Publication Date: Aug 12, 2022
• Publication Date: Aug 3, 2022
• Deposit Date: Aug 8, 2022
• Publicly Available Date: Aug 15, 2022
• Journal: Experimental Physiology
• Print ISSN: 0958-0670
• Electronic ISSN: 1469-445X
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1113/EP090367
• Keywords: RESEARCH ARTICLE, MUSCLE, electromyography, firing rate variability, motor unit, muscle force accuracy, neuromuscular function
• Public URL: https://nottingham-repository.worktribe.com/output/9589058
• Publisher URL: https://physoc.onlinelibrary.wiley.com/doi/10.1113/EP090367
• Additional Information: Received: 2022-02-11; Accepted: 2022-07-28; Published: 2022-08-03