All Outputs (19)

A method to assess the mitochondrial respiratory capacity of complexes I and II from frozen tissue using the Oroboros O2k-FluoRespirometer (2023)
Journal Article

High-resolution respirometry methods allow for the assessment of oxygen consumption by the electron transfer systems within cells, tissue samples, and isolated mitochondrial preparations. As mitochondrial integrity is compromised by the process of cr... Read More about A method to assess the mitochondrial respiratory capacity of complexes I and II from frozen tissue using the Oroboros O2k-FluoRespirometer.

A Common Anaesthetic, MS-222, Alters Measurements Made Using High-Resolution Respirometry in the Three-Spined Stickleback (Gasterosteus aculeatus) (2023)
Journal Article

Submersion in the anaesthetic MS-222 is a well-established and effective method used during the euthanasia of fish, but the consequences of treatment with this anaesthetic for mitochondrial respiration are yet to be established. This is important to... Read More about A Common Anaesthetic, MS-222, Alters Measurements Made Using High-Resolution Respirometry in the Three-Spined Stickleback (Gasterosteus aculeatus).

The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity (2022)
Journal Article

Minicolumns are thought to be a fundamental neural unit in the neocortex and their replication may have formed the basis of the rapid cortical expansion that occurred during primate evolution. We sought evidence of minicolumns in the primary visual c... Read More about The large numbers of minicolumns in the primary visual cortex of humans, chimpanzees and gorillas are related to high visual acuity.

Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases (2022)
Journal Article

The mitochondrial ATP synthase is responsible for the production of cellular ATP, and it does so by harnessing the membrane potential of the mitochondria that is produced by the sequential oxidation of select cellular metabolites. Since the structura... Read More about Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases.

Sox-positive cell population in the adult cerebellum increases upon tissue degeneration (2021)
Journal Article

Adult neurogenesis is well-described in the subventricular and subgranular zones of the mammalian brain. Recent observations that resident glia express stem cell markers in some areas of the brain not traditionally associated with neurogenesis hint t... Read More about Sox-positive cell population in the adult cerebellum increases upon tissue degeneration.

Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain (2021)
Journal Article

Mitochondria are intracellular organelles responsible for cellular respiration with one of their major roles in the production of energy in the form of ATP. Activities with increased energetic demand are especially dependent on efficient ATP producti... Read More about Acute Imidacloprid Exposure Alters Mitochondrial Function in Bumblebee Flight Muscle and Brain.

Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex (2021)
Journal Article

Ageing is a major risk factor for many of the most prevalent diseases, including neurode-generative diseases, cancer, and heart disease. As the global population continues to age, behavioural interventions that can promote healthy ageing will improve... Read More about Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex.

Sequence and structure comparison of ATP synthase F0 subunits 6 and 8 in notothenioid fish (2021)
Journal Article

Mitochondrial changes such as tight coupling of the mitochondria have facilitated sustained oxygen and respiratory activity in haemoglobin-less icefish of the Channichthyidae family. We aimed to characterise features in the sequence and structure of... Read More about Sequence and structure comparison of ATP synthase F0 subunits 6 and 8 in notothenioid fish.

Low-Power Sonication Can Alter Extracellular Vesicle Size and Properties (2021)
Journal Article

Low-power sonication is widely used to disaggregate extracellular vesicles (EVs) after isolation, however, the effects of sonication on EV samples beyond dispersion are unclear. The present study analysed the characteristics of EVs collected from mes... Read More about Low-Power Sonication Can Alter Extracellular Vesicle Size and Properties.

The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise (2021)
Journal Article

One of the genes which has been linked to the onset of juvenile/early onset Parkinson’s disease (PD) is PINK1. There is evidence that supports the therapeutic potential of exercise in the alleviation of PD symptoms. It is possible that exercise may e... Read More about The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise.

ATP synthase and Alzheimer's disease: putting a spin on the mitochondrial hypothesis (2020)
Journal Article

It is estimated that over 44 million people across the globe have dementia, and half of these cases are believed to be Alzheimer's disease (AD). As the proportion of the global population which is over the age 60 increases so will the number of indiv... Read More about ATP synthase and Alzheimer's disease: putting a spin on the mitochondrial hypothesis.

A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats (2019)
Journal Article

It is accepted that smaller mammals with higher metabolic rates have shorter lifespans. The very few species that do not follow these rules can give insights into interesting differences. The recorded maximum lifespans of bats are exceptional - over... Read More about A comparison of the mitochondrial proteome and lipidome in the mouse and long-lived Pipistrelle bats.

Mitochondrial respiratory states and rates (2019)
Other

As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory es... Read More about Mitochondrial respiratory states and rates.

Exposure to the ROCK inhibitor fasudil promotes gliogenesis of neural stem cells in vitro (2018)
Journal Article

Fasudil is a clinically approved Rho-associated protein kinase (ROCK) inhibitor that has been used widely to treat cerebral consequences of subarachnoid haemorrhage. It is known to have a positive effect on animal models of neurological disorders inc... Read More about Exposure to the ROCK inhibitor fasudil promotes gliogenesis of neural stem cells in vitro.

Mouse mitochondrial lipid composition is defined by age in brain and muscle (2017)
Journal Article

Functionality of the lipid rich mitochondrial organelle declines with increased age. Recent advances in lipidomic technologies allowed us to perform a global characterisation of lipid composition in two different tissue types and age ranges. Ultra-hi... Read More about Mouse mitochondrial lipid composition is defined by age in brain and muscle.

Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration (2016)
Journal Article

Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic anhydrases perform a crucial role in the conversion of carbon dioxide and water into bicarbonate and protons. However, there is little information about carbonic anhydrase... Read More about Mitochondrial proteomic profiling reveals increased carbonic anhydrase II in aging and neurodegeneration.

Mitochondrial complex 1 activity measured by spectrophotometry is reduced across all brain regions in ageing and more specifically in neurodegeneration (2016)
Journal Article

Mitochondrial function, in particular complex 1 of the electron transport chain (ETC), has been shown to decrease during normal ageing and in neurodegenerative disease. However, there is some debate concerning which area of the brain has the greatest... Read More about Mitochondrial complex 1 activity measured by spectrophotometry is reduced across all brain regions in ageing and more specifically in neurodegeneration.

Analysis of mitochondrial haemoglobin in Parkinson's disease brain (2016)
Journal Article

Mitochondrial dysfunction is an early feature of neurodegeneration. We have shown there are mitochondrial haemoglobin changes with age and neurodegeneration. We hypothesised that altered physiological processes are associated with recruitment and loc... Read More about Analysis of mitochondrial haemoglobin in Parkinson's disease brain.

A mitochondrial location for haemoglobins--dynamic distribution in ageing and Parkinson's disease (2014)
Journal Article