All Outputs (90)

Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives (2024)
Journal Article

Introduction The Sustainable Development Goals of the United Nations include a commitment to “leave no one behind” as a universal goal. To achieve this in geriatric oncology (GO) worldwide, it is important to understand the current state of GO at an... Read More about Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives.

Factors influencing older women's decision‐making related to treatment of operable breast cancer: A qualitative systematic review (2024)
Journal Article

Objective: There is variation in practice in the treatment of older women with breast cancer. International guidelines highlight the importance of patient autonomy in treatment decision‐making. The aim of this study is to identify factors which influ... Read More about Factors influencing older women's decision‐making related to treatment of operable breast cancer: A qualitative systematic review.

Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network (2023)
Journal Article

Introduction The present study was designed to describe tumour features and treatments for patients with breast cancer. It also aimed at assessing the risk of distant metastases in relation to biological profiles, disease stages and treatment. Meth... Read More about Treatment and outcomes in breast cancer patients: A cross section study from the EUSOMA breast centre network.

Geriatric Oncology as an Unmet Workforce Training Need in the United Kingdom—A Narrative Review by the British Oncology Network for Undergraduate Societies (BONUS) and the International Society of Geriatric Oncology (SIOG) UK Country Group (2023)
Journal Article

Cancer is a disease associated with ageing. Managing cancer in older adults may prove challenging owing to pre-existing frailty, comorbidity, and wider holistic needs, as well as the unclear benefits and harms of standard treatment options. With the... Read More about Geriatric Oncology as an Unmet Workforce Training Need in the United Kingdom—A Narrative Review by the British Oncology Network for Undergraduate Societies (BONUS) and the International Society of Geriatric Oncology (SIOG) UK Country Group.

Outcomes of complex oncoplastic breast surgery in older women. Analysis of data from the Age Gap cohort study (2023)
Journal Article

Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative (2023)
Journal Article

As older adults with cancer are underrepresented in randomized clinical trials (RCT), there is limited evidence on which to rely for treatment decisions for this population. Commonly used RCT endpoints for the assessment of treatment efficacy are mor... Read More about Assessing patient-reported outcomes (PROs) and patient-related outcomes in randomized cancer clinical trials for older adults: Results of DATECAN-ELDERLY initiative.

Geriatric assessment for older people with cancer: policy recommendations (2023)
Journal Article

Most cancers occur in older people and the burden in this age group is increasing. Over the past two decades the evidence on how best to treat this population has increased rapidly. However, implementation of new best practices has been slow and need... Read More about Geriatric assessment for older people with cancer: policy recommendations.

SIOG COVID-19 Working Group recommendations on COVID-19 therapeutic approaches in older adults with cancer (2023)
Journal Article

Oncoplastic breast surgery in older women with primary breast cancer: a systematic review (2023)
Journal Article

Oncoplastic procedures allow excision of larger breast tumours, or unfavourable tumour/breast ratio lesions while achieving a good cosmetic outcome. This increases the pool of patients eligible for breast conservation over mastectomy, reducing the ne... Read More about Oncoplastic breast surgery in older women with primary breast cancer: a systematic review.

Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival (2023)
Journal Article

Introduction Breast cancer in older women tends to have more favourable biology, compared to younger women. Androgen receptor (AR) is significant for breast tumour carcinogenesis; however, the role of AR in older women has not been fully explored.... Read More about Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival.

Improving the Assessment and Diagnosis of Breast Lymphedema after Treatment for Breast Cancer (2023)
Journal Article

Lymphedema can develop after treatment for breast cancer (BCRL). Lymphedema of the breast is not well studied. Currently, the main techniques used to diagnose and monitor the effectiveness of treatment are subjective clinician assessment and patient... Read More about Improving the Assessment and Diagnosis of Breast Lymphedema after Treatment for Breast Cancer.

The Association Between Medication Use in Older Women with Early-Stage Operable Primary Breast Cancer and Decision Regarding Primary Treatment (2023)
Journal Article

Background Polypharmacy is one factor contributing to increased mortality, hospitalization, and adverse drug reactions in older adults. The aim of this study was to measure the prevalence of polypharmacy in a cohort of older women with early-stage op... Read More about The Association Between Medication Use in Older Women with Early-Stage Operable Primary Breast Cancer and Decision Regarding Primary Treatment.

Revisiting primary endocrine therapy versus surgery in older women with breast cancer: meta-analysis (2023)
Journal Article

Background Old age is associated with increased co-morbidities, resulting in reduced life expectancy. Primary endocrine therapy is an alternative to primary surgical therapy for patients with breast cancer and increased co-morbidities. The aim was to... Read More about Revisiting primary endocrine therapy versus surgery in older women with breast cancer: meta-analysis.

The impact of age on health utility values for older women with early-stage breast cancer: a systematic review and meta-regression (2022)
Journal Article

Introduction: An increasing number of postmenopausal women are diagnosed with breast cancer at an older age (≥ 70years). There is a lack of synthesised health utility data to support decision-making for managing breast cancer in this older population... Read More about The impact of age on health utility values for older women with early-stage breast cancer: a systematic review and meta-regression.

The impact of the SARS-COV-2 pandemic on the quality of breast cancer care in EUSOMA-certified breast centres (2022)
Journal Article

Aims: We analysed the impact of the SARS-CoV-2 pandemic (COVID-19) on the quality of breast cancer care in certified EUSOMA (European Society of Breast Cancer Specialists) breast centres. Materials and methods: The results of the EUSOMA quality indic... Read More about The impact of the SARS-COV-2 pandemic on the quality of breast cancer care in EUSOMA-certified breast centres.

Molecular Biomarker Expression in Window of Opportunity Studies for Oestrogen Receptor Positive Breast Cancer—A Systematic Review of the Literature (2022)
Journal Article

Window of opportunity (WoO) trials create the opportunity to demonstrate pharmacodynamic parameters of a drug in vivo and have increasing use in breast cancer research. Most breast cancer tumours are oestrogen receptor-positive (ER+), leading to the... Read More about Molecular Biomarker Expression in Window of Opportunity Studies for Oestrogen Receptor Positive Breast Cancer—A Systematic Review of the Literature.

Immediate breast reconstruction uptake in older women with primary breast cancer: systematic review (2022)
Journal Article

BACKGROUND: Postmastectomy immediate breast reconstruction (PMIBR) may improve the quality of life of patients with breast cancer, of whom older women (aged 65 years or more) are a growing proportion. This study aimed to assess PMIBR in older women w... Read More about Immediate breast reconstruction uptake in older women with primary breast cancer: systematic review.

Updated SIOG COVID-19 working group recommendations on COVID-19 vaccination among older adults with cancer (2022)
Journal Article

Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT (2022)
Journal Article

Background: In breast cancer management, age-related practice variation is widespread, with older women having lower rates of surgery and chemotherapy than younger women, based on the premise of reduced treatment tolerance and benefit. This may contr... Read More about Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT.

Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review (2022)
Journal Article

Background: The benefit of chemotherapy for older patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer (EBC) is a key area of debate. Gene expression profiling (GEP) may identify p... Read More about Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review.