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Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review

Battisti, Nicolò Matteo Luca; De Glas, Nienke; Soto-Perez-de-Celis, Enrique; Liposits, Gabor; Bringuier, Michael; Walko, Christine; Lichtman, Stuart M.; Aapro, Matti; Cheung, Kwok Leung; Biganzoli, Laura; Ring, Alistair; Portielje, Johanneke; Wildiers, Hans; Brain, Etienne

Authors

Nicolò Matteo Luca Battisti

Nienke De Glas

Enrique Soto-Perez-de-Celis

Gabor Liposits

Michael Bringuier

Christine Walko

Stuart M. Lichtman

Matti Aapro

Laura Biganzoli

Alistair Ring

Johanneke Portielje

Hans Wildiers

Etienne Brain



Abstract

Background: The benefit of chemotherapy for older patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer (EBC) is a key area of debate. Gene expression profiling (GEP) may identify patients deriving benefit, but their predictive role has not been established for older adults. We summarise evidence on efficacy, safety, and quality-of-life impacts of chemotherapy and on GEP use and impact in older HR-positive, HER2-negative EBC patients. Methods: We conducted a literature search of PubMed and Embase on publications describing prospective studies evaluating chemotherapy in older adults with HR-positive, HER2-negative EBC and on publications describing retrospective and prospective studies evaluating GEP in older adults. Results: Eight publications on chemotherapy use, including 2,035 older patients with EBC were selected. Only one trial evaluated chemotherapy survival benefits in older adults, showing no benefit. Of four studies comparing different regimens, only one showed the superiority of taxanes versus anthracyclines alone. Those investigating alternative regimens did not show improvements over standard regimens despite significant limitations. Five publications on GEP, including 445,323 older patients, were included and investigated Oncotype DX. Limited evidence shows that GEP aids treatment decisions in this population. GEP was offered less frequently to older versus younger patients. Higher Recurrence Score was prognostic for distant recurrence, but chemotherapy did not improve prognosis. Conclusions: In older patients with HR-positive, HER2-negative, chemotherapy survival benefits EBC are unclear and GEP is less used. Although its prognostic role is well established, its predictive role remains unknown.

Citation

Battisti, N. M. L., De Glas, N., Soto-Perez-de-Celis, E., Liposits, G., Bringuier, M., Walko, C., …Brain, E. (2022). Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review. European Journal of Cancer, 172, 158-170. https://doi.org/10.1016/j.ejca.2022.05.039

Journal Article Type Review
Acceptance Date May 24, 2022
Online Publication Date Jun 28, 2022
Publication Date Sep 1, 2022
Deposit Date Jun 30, 2022
Publicly Available Date Jun 29, 2023
Journal European Journal of Cancer
Print ISSN 0959-8049
Electronic ISSN 1879-0852
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 172
Pages 158-170
DOI https://doi.org/10.1016/j.ejca.2022.05.039
Keywords Cancer Research; Oncology
Public URL https://nottingham-repository.worktribe.com/output/8767976
Publisher URL https://www.ejcancer.com/article/S0959-8049(22)00325-2/fulltext
Related Public URLs https://www.sciencedirect.com/science/article/abs/pii/S0959804922003252

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