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All Outputs (18)

An overview of the Nottingham Research Programme on Primary Breast Cancer in Older Women: breast cancer in older women (2021)
Journal Article

The incidence of breast cancer increases with age. Despite this, most research in this field is aimed at the younger patient. Preliminary studies have shown that older women with breast cancer have distinct biological features compared to their young... Read More about An overview of the Nottingham Research Programme on Primary Breast Cancer in Older Women: breast cancer in older women.

Does Breast Cancer Surgery Impact Functional Status and Independence in Older Patients? A Narrative Review (2021)
Journal Article

Surgery is the recommended treatment modality for primary breast cancer. Breast cancer surgery is non-visceral; therefore, it is often assumed that the subsequent impact on functional status in older women is less significant compared to other cancer... Read More about Does Breast Cancer Surgery Impact Functional Status and Independence in Older Patients? A Narrative Review.

Concordance between core needle biopsy and surgical excision specimens for Ki-67 in breast cancer–a systematic review of the literature (2021)
Journal Article

Aims: The biomarkers oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) are routinely measured in patients with breast cancer with international consensus on how they should be interpreted. There i... Read More about Concordance between core needle biopsy and surgical excision specimens for Ki-67 in breast cancer–a systematic review of the literature.

Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial (2021)
Journal Article

Background The Bridging the Age Gap in Breast Cancer research programme sought to improve treatment decision-making for older women with breast cancer by developing and testing, in a cluster randomised trial (n = 1339 patients), two decision support... Read More about Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial.

Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality (2021)
Journal Article

Background: Radiotherapy reduces in-breast recurrence risk in early breast cancer (EBC) in older women. This benefit may be small and should be balanced against treatment effect and holistic patient assessment. This study described treatment patterns... Read More about Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality.

Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG) (2021)
Journal Article

Breast cancer is increasingly prevalent in older adults and is a substantial part of routine oncology practice. However, management of breast cancer in this population is challenging because the disease is highly heterogeneous and there is insufficie... Read More about Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG).

Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer (2021)
Journal Article

Background: Chemotherapy improves outcomes for high risk early breast cancer (EBC) patients but is infrequently offered to older individuals. This study determined if there are fit older patients with high-risk disease who may benefit from chemothera... Read More about Bridging The Age Gap: observational cohort study of effects of chemotherapy and trastuzumab on recurrence, survival and quality of life in older women with early breast cancer.

Cost-Effectiveness Modeling of Surgery Plus Adjuvant Endocrine Therapy Versus Primary Endocrine Therapy Alone in UK Women Aged 70 and Over With Early Breast Cancer (2021)
Journal Article

Objectives: Approximately 20% of UK women aged 70+ with early breast cancer receive primary endocrine therapy (PET) instead of surgery. PET reduces surgical morbidity but with some survival decrement. To complement and utilize a treatment dependent p... Read More about Cost-Effectiveness Modeling of Surgery Plus Adjuvant Endocrine Therapy Versus Primary Endocrine Therapy Alone in UK Women Aged 70 and Over With Early Breast Cancer.

The impact of breast cancer surgery on functional status in older women – A systematic review of the literature (2021)
Journal Article

Primary endocrine therapy as treatment of breast cancer is only recommended in older women with limited life expectancy. However, many older women opt for endocrine therapy due to concerns regarding frailty and potential decline in function after sur... Read More about The impact of breast cancer surgery on functional status in older women – A systematic review of the literature.

Bridging the age gap in breast cancer: impact of omission of breast cancer surgery in older women with oestrogen receptor-positive early breast cancer on quality-of-life outcomes (2021)
Journal Article

BACKGROUND: Primary endocrine therapy may be an alternative treatment for less fit women with oestrogen receptor (ER)-positive breast cancer. This study compared quality-of-life (QoL) outcomes in older women treated with surgery or primary endocrine... Read More about Bridging the age gap in breast cancer: impact of omission of breast cancer surgery in older women with oestrogen receptor-positive early breast cancer on quality-of-life outcomes.

Bridging the age gap in breast cancer: cluster randomized trial of the effects of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices (2021)
Journal Article

Background: Rates of surgery and adjuvant therapy for breast cancer vary widely between breast units. This may contribute to differences in survival. This cluster RCT evaluated the impact of decision support interventions (DESIs) for older women with... Read More about Bridging the age gap in breast cancer: cluster randomized trial of the effects of two decision support interventions for older women with operable breast cancer on quality of life, survival, decision quality, and treatment choices.

The impact of tumour biology on the management of primary breast cancer in older women—based on a research programme in Nottingham (2021)
Journal Article

The incidence of breast cancer increases with age. Average life expectancies are increasing; the older population is expanding globally. This presents a huge challenge on an international scale in the coming years as more older people are living with... Read More about The impact of tumour biology on the management of primary breast cancer in older women—based on a research programme in Nottingham.

Treatment choices for older women with primary operable breast cancer and cognitive impairment: Results from a prospective, multicentre cohort study (2021)
Journal Article

© 2020 The Authors Objectives: The presence of dementia co-existing with a diagnosis of breast cancer may render management more challenging and have a substantial impact on oncological outcomes. The aim of this study was to examine the treatment and... Read More about Treatment choices for older women with primary operable breast cancer and cognitive impairment: Results from a prospective, multicentre cohort study.