Concordance between core needle biopsy and surgical excision specimens for Ki-67 in breast cancer–a systematic review of the literature

Kalvala, Jahnavi; Parks, Ruth M.; Green, Andrew R.; Cheung, Kwok Leung

Abstract

Aims: The biomarkers oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) are routinely measured in patients with breast cancer with international consensus on how they should be interpreted. There is evidence to support use of other biomarkers to give more detailed predictive and prognostic information. Ki-67 is one example, and measures the proliferative activity of cancer cells. It is important that this can be performed at diagnosis of breast cancer for patients who do not have initial surgical treatment (mainly older women) and those receiving neoadjuvant therapies. Methods and results: A systematic review was performed to assess concordance of measurement of Ki-67 between core needle biopsy (CNB) samples and surgical excision (SE) samples in patients with invasive breast cancer. MEDLINE and Embase databases were searched. Studies were eligible if performed within the last 10years; included quantitative measurement of Ki-67 in both CNB and SE samples with no prior breast cancer treatment; measured concordance between two samples; and had full text available. A total of 22 studies, including 5982 paired CNB and SE samples on which Ki-67 was measured, were appraised. Overall, there appeared to be concordance; however, reliability was unclear. Where given, the Cohen’s kappa coefficient (κ) of correlation between samples ranged from 0.261 to 0.712. The concordance rate between CNB and SE where measured as a percentage had a range from 70.3 to 92.7%. Conclusions: Assessment of level of concordance of Ki-67 between CNB and SE samples is hampered by different methodologies. International consensus on Ki-67 measurement is urgently needed.

• Journal Article Type: Article
• Acceptance Date: Aug 30, 2021
• Online Publication Date: Sep 2, 2021
• Publication Date: 2022-02
• Deposit Date: Sep 9, 2021
• Publicly Available Date: Sep 3, 2022
• Journal: Histopathology
• Print ISSN: 0309-0167
• Electronic ISSN: 1365-2559
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 80
• Issue: 3
• Pages: 468-484
• DOI: https://doi.org/10.1111/his.14555
• Keywords: General Medicine; Histology; Pathology and Forensic Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/6190465
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/his.14555
• Additional Information: This is the peer reviewed version of the following article: Kalvala, J., Parks, R.M., Green, A.R. and Cheung, K.-L. (2021), Concordance between core needle biopsy and surgical excision specimens for Ki-67 in breast cancer – a systematic review of the literature. Histopathology. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1111/his.14555. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."