All Outputs (57)

Quick and simple: psoas density measurement is an independent predictor of anastomotic leak and other complications after colorectal resection (2019)
Journal Article

Purpose: Radiologically-defined sarcopenia has been shown to predict negative outcomes after cancer surgery, however radiological assessment of sarcopenia often requires additional software and standardisation against anthropomorphic data. Measuring... Read More about Quick and simple: psoas density measurement is an independent predictor of anastomotic leak and other complications after colorectal resection.

The efficacy of ‘static’ training interventions for improving indices of cardiorespiratory fitness in premenopausal females (2018)
Journal Article

PURPOSE: Cardiovascular disease (CVD) is the leading cause of death worldwide. Many risk factors for CVD can be modified pharmacologically; however, uptake of medications is low, especially in asymptomatic people. Exercise is also effective at reduc... Read More about The efficacy of ‘static’ training interventions for improving indices of cardiorespiratory fitness in premenopausal females.

Fibrin glue is a quick and effective treatment for primary and recurrent pilonidal sinus disease (2018)
Journal Article

Background Pilonidal sinus disease (PSD) is a common, chronic inflammatory condition involving hair follicles within the natal cleft. It mainly affects young males and creates a significant health, social and economic burden. Traditional surgery i... Read More about Fibrin glue is a quick and effective treatment for primary and recurrent pilonidal sinus disease.

‘Blood in pee’ campaign: Increased demand on secondary care with no change in cancers diagnosed (2018)
Journal Article

Objective: As part of the national Be Clear on Cancer campaign, the ‘blood in pee’ campaign was launched in 2013. We aimed to evaluate the impact of the campaign on 2-week wait (2WW) referrals and the resulting diagnoses of malignancy at a single tr... Read More about ‘Blood in pee’ campaign: Increased demand on secondary care with no change in cancers diagnosed.

Fibrin glue obliteration is safe, effective and minimally invasive as first line treatment for pilonidal sinus disease in children (2018)
Journal Article

Background / Purpose: Sacrococcygeal pilonidal sinus disease (PSD) has an incidence of 1.2–2.5/1000 in children. Onset is around puberty. Symptoms of recurrent abscess and chronic suppuration may interfere with education and social integration. Treat... Read More about Fibrin glue obliteration is safe, effective and minimally invasive as first line treatment for pilonidal sinus disease in children.

The use of cannabinoids in colitis: a systematic review and meta-analysis (2018)
Journal Article

Background: Clinical trials investigating the use of cannabinoid drugs for the treatment of intestinal inflammation are anticipated secondary to preclinical literature demonstrating efficacy in reducing inflammation. Methods: We systematically revie... Read More about The use of cannabinoids in colitis: a systematic review and meta-analysis.

Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery (Protocol) (2018)
Journal Article

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate in adult participants undergoing all types of surgery, the effects of pre-emptive and preventive non-steroidal anti-inflammatory drugs (NSAIDs) com... Read More about Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery (Protocol).

A multicentre integration of a computer-led follow-up of prostate cancer is valid and safe (2018)
Journal Article

© 2018 The Authors BJU International published by John Wiley & Sons Ltd on behalf of BJU International Objective: To test a computer-led follow-up service for prostate cancer in two UK hospitals; the testing aimed to validate the computer expert sy... Read More about A multicentre integration of a computer-led follow-up of prostate cancer is valid and safe.

Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost‑efective and should be replaced with universally performed pre‑endoscopy serology in patients on a suspected cancer pathway (2018)
Journal Article

Background: Random duodenal biopsy to exclude coeliac disease during upper gastrointestinal endoscopy for the investigation of iron defciency anaemia remains a common procedure, but is expensive and time-consuming. Serological investigation for coeli... Read More about Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost‑efective and should be replaced with universally performed pre‑endoscopy serology in patients on a suspected cancer pathway.

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study (2018)
Journal Article

NICE guidance on sepsis is of limited value in postoperative colorectal patients: the scores that cry ‘wolf!’ (2018)
Journal Article

Background and aims Late recognition of sepsis and consequent death remains a problem. To address this, the National Institute for Health and Care Excellence has published updated guidance recommending the use of the Quick Sequential Organ Failure A... Read More about NICE guidance on sepsis is of limited value in postoperative colorectal patients: the scores that cry ‘wolf!’.

Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men (2017)
Journal Article

Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a “muscle-full” state. However, the e... Read More about Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.

Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon (2017)
Journal Article

Objective: We sought to quantify the anti-inflammatory effects of two cannabinoid drugs, cannabidiol (CBD) and palmitoylethanolamide (PEA), in cultured cell lines and compared this effect with experimentally inflamed explant human colonic tissue. The... Read More about Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon.

DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease (2017)
Journal Article

The human genome contains ?30,000 CpG islands (CGIs). While CGIs associated with promoters nearly always remain unmethylated, many of the ?9,000 CGIs lying within gene bodies become methylated during development and differentiation. Both promoter and... Read More about DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease.

A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle (2017)
Journal Article

Current methods to quantify in vivo RNA dynamics are limited. Here, we developed a novel stable isotope (D2O) methodology to quantify RNA synthesis (i.e., ribosomal biogenesis) in cells, animal models, and humans. First, proliferating C2C12 cells wer... Read More about A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle.

Robotic colorectal surgery: previous laparoscopic colorectal experience is not essential (2017)
Journal Article

A background in minimally invasive colorectal surgery (MICS) has been thought to be essential prior to robotic-assisted colorectal surgery (RACS). Our aim was to determine whether MICS is essential prior to starting RACS training based on results fro... Read More about Robotic colorectal surgery: previous laparoscopic colorectal experience is not essential.

Baseline morphine consumption may explain between-study heterogeneity in meta-analyses of adjuvant analgesics and improve precision and accuracy of effect estimates (2017)
Journal Article

BACKGROUND: Statistical heterogeneity can increase the uncertainty of results and reduce the quality of evidence derived from systematic reviews. At present, it is uncertain what the major factors are that account for heterogeneity in meta-analyses o... Read More about Baseline morphine consumption may explain between-study heterogeneity in meta-analyses of adjuvant analgesics and improve precision and accuracy of effect estimates.

Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer (2017)
Journal Article

Hypomethylation of LINE-1 repeats in cancer has been proposed as the main mechanism behind their activation; this assumption, however, was based on findings from early studies that were biased toward young and transpositionally active elements. Here,... Read More about Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer.

Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers (2017)
Journal Article

Background Oesophageal Doppler monitoring (ODM) is used clinically to optimize cardiac output (CO) and guide fluid therapy. Despite limited experimental evidence, it is assumed that increasing CO increases visceral microvascular blood flow (MBF).... Read More about Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers.

Fibrin glue for pilonidal sinus disease (2017)
Journal Article

Background Pilonidal sinus disease is a common condition that mainly affects young adults. This condition can cause significant pain and impairment of normal activities. No consensus currently exists on the optimum treatment for pilonidal sinus and... Read More about Fibrin glue for pilonidal sinus disease.