Thomas P. Heinink
Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers
Heinink, Thomas P.; Read, David J.; Mitchell, William K.; Bhalla, Ashish; Lund, Jonathan N.; Phillips, Bethan E.; Williams, John P.
David J. Read
William K. Mitchell
Jonathan N. Lund
Bethan E. Phillips
John P. Williams
Oesophageal Doppler monitoring (ODM) is used clinically to optimize cardiac output (CO) and guide fluid therapy. Despite limited experimental evidence, it is assumed that increasing CO increases visceral microvascular blood flow (MBF). We used contrast-enhanced ultrasound (CEUS) to assess whether ODM-guided optimization of CO altered MBF.
Sixteen healthy male volunteers (62 ± 3·4 years) were studied. Baseline measurements of CO were recorded via ODM. Hepatic and renal MBF was assessed via CEUS. Saline 0·9% was administered to optimize CO according to a standard protocol and repeat CEUS performed. Time–intensity curves were constructed, allowing organ perfusion calculation via time to 5% perfusion (TT5). MBF was assessed via organ perfusion rise time (RT) (5–95%).
CO increased (4535 ± 241 ml/min versus 5442 ± 329 ml/min, P
|Journal Article Type||Article|
|Journal||Clinical Physiology and Functional Imaging|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Heinink, T. P., Read, D. J., Mitchell, W. K., Bhalla, A., Lund, J. N., Phillips, B. E., & Williams, J. P. (in press). Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers. Clinical Physiology and Functional Imaging, doi:10.1111/cpf.12401|
|Keywords||cardiac output; CEUS ; contrast-enhanced Ultrasound; healthy volunteers; oesophageal Doppler|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf|
|Additional Information||This is the peer reviewed version of the following article: Heinink, T. P., Read, D. J., Mitchell, W. K., Bhalla, A., Lund, J. N., Phillips, B. E. and Williams, J. P. (2017), Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers. Clin Physiol Funct Imaging, which has been published in final form at http://dx.doi.org/10.1111/cpf.12401. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.|
Submitted manuscript to functional imaging July 2016.pdf
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
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