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Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults

Din, Ushnah S. U.; Sian, Tanvir S.; Deane, Colleen S.; Smith, Ken; Gates, Amanda; Lund, Jonathan N.; Williams, John P.; Rueda, Ricardo; Pereira, Suzette L.; Atherton, Philip J.; Phillips, Bethan E.

Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults Thumbnail


Authors

Ushnah S. U. Din

Tanvir S. Sian

Colleen S. Deane

KENNETH SMITH KEN.SMITH@NOTTINGHAM.AC.UK
Professor of Metabolic Mass Spectrometry

Amanda Gates

JONATHAN LUND JON.LUND@NOTTINGHAM.AC.UK
Clinical Associate Professor

JOHN WILLIAMS john.williams7@nottingham.ac.uk
Clinical Associate Professor

Ricardo Rueda

Suzette L. Pereira

PHILIP ATHERTON philip.atherton@nottingham.ac.uk
Professor of Clinical, metabolic & Molecular Physiology

BETH PHILLIPS beth.phillips@nottingham.ac.uk
Professor of Translational Physiology



Abstract

Postprandial macro-and microvascular blood flow and metabolic dysfunction manifest with advancing age, so vascular transmuting interventions are desirable. In this randomised, singleblind, placebo-controlled, crossover trial, we investigated the impact of the acute administration of green tea extract (GTE; containing ~500 mg epigallocatechin-3-gallate) versus placebo (CON), alongside an oral nutritional supplement (ONS), on muscle macro-and microvascular, cerebral macrovascular (via ultrasound) and leg glucose/insulin metabolic responses (via arterialised/venous blood samples) in twelve healthy older adults (42% male, 74 ± 1 y). GTE increased m. vastus lateralis microvascular blood volume (MBV) at 180 and 240 min after ONS (baseline: 1.0 vs. 180 min: 1.11 ± 0.02 vs. 240 min: 1.08 ± 0.04, both p < 0.005), with MBV significantly higher than CON at 180 min (p < 0.05). Neither the ONS nor the GTE impacted m. tibialis anterior perfusion (p > 0.05). Leg blood flow and vascular conductance increased, and vascular resistance decreased similarly in both conditions (p < 0.05). Small non-significant increases in brachial artery flow-mediated dilation were observed in the GTE only and middle cerebral artery blood flow did not change in response to GTE or CON (p > 0.05). Glucose uptake increased with the GTE only (0 min: 0.03 ± 0.01 vs. 35 min: 0.11 ± 0.02 mmol/min/leg, p = 0.007); however, glucose area under the curve and insulin kinetics were similar between conditions (p > 0.05). Acute GTE supplementation enhances MBV beyond the effects of an oral mixed meal, but this improved perfusion does not translate to increased leg muscle glucose uptake in healthy older adults.

Journal Article Type Article
Acceptance Date Oct 28, 2021
Online Publication Date Oct 29, 2021
Publication Date Nov 1, 2021
Deposit Date Nov 12, 2021
Publicly Available Date Nov 12, 2021
Journal Nutrients
Electronic ISSN 2072-6643
Publisher MDPI AG
Peer Reviewed Peer Reviewed
Volume 13
Issue 11
Article Number 3895
DOI https://doi.org/10.3390/nu13113895
Keywords Food Science; Nutrition and Dietetics
Public URL https://nottingham-repository.worktribe.com/output/6681621
Publisher URL https://www.mdpi.com/2072-6643/13/11/3895

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