All Outputs (58)

The Potential of Plant-Produced Virus-like Particle Vaccines for African Horse Sickness and Other Equine Orbiviruses (2024)
Journal Article

African horse sickness is a devastating viral disease of equids. It is transmitted by biting midges of the genus Culicoides with mortalities reaching over 90% in naïve horses. It is endemic to sub-Saharan Africa and is seasonally endemic in many part... Read More about The Potential of Plant-Produced Virus-like Particle Vaccines for African Horse Sickness and Other Equine Orbiviruses.

Development of Virus-like Particle Plant-Based Vaccines against Avian H5 and H9 Influenza A Viruses (2024)
Journal Article

Avian influenza A virus (AIV) is a significant cause of mortality in poultry, causing substantial economic loss, particularly in developing countries, and has zoonotic potential. For example, highly pathogenic avian influenza (HPAI) viruses of the H5... Read More about Development of Virus-like Particle Plant-Based Vaccines against Avian H5 and H9 Influenza A Viruses.

Combined biolistic and cell penetrating peptide delivery for the development of scalable intradermal DNA vaccines (2024)
Journal Article

Physical-based gene delivery via biolistic methods (such as the Helios gene gun) involve precipitation of nucleic acids onto microparticles and direct transfection through cell membranes of exposed tissue (e.g. skin) by high velocity acceleration. Th... Read More about Combined biolistic and cell penetrating peptide delivery for the development of scalable intradermal DNA vaccines.

Mapping Polyclonal Antibody Responses to Infection Using Next-Generation Phage Display (2023)
Book Chapter

Peptide phage display has historically been used to epitope map monoclonal antibodies. More recently, by coupling this method with next-generation sequencing (so-called next-generation phage display, NGPD) to mass screen peptide binding events, the m... Read More about Mapping Polyclonal Antibody Responses to Infection Using Next-Generation Phage Display.

Immune responses to Tilapia lake virus infection: what we know and what we don't know (2023)
Journal Article

Tilapia lake virus (TiLV) is a novel contagious pathogen associated with a lethal disease affecting and decimating tilapia populations on several continents across the globe. Fish viral diseases, such as Tilapia lake virus disease (TiLVD), represent... Read More about Immune responses to Tilapia lake virus infection: what we know and what we don't know.

Comparative transcriptome analysis of spleen of Newcastle Disease Virus (NDV) infected chicken and Japanese quail: a potential role of NF-κβ pathway activation in NDV resistance (2023)
Journal Article

Newcastle disease (ND) affects a few hundred avian species including chicken and several species of domestic and wild birds. The clinical outcome of Newcastle disease virus (NDV) infection ranges from mild to severe fatal disease depending on the NDV... Read More about Comparative transcriptome analysis of spleen of Newcastle Disease Virus (NDV) infected chicken and Japanese quail: a potential role of NF-κβ pathway activation in NDV resistance.

Advances in the understanding, detection and management of equine strangles (2023)
Journal Article

Streptococcus equi subspecies equi (S. equi) is the causative organism of the upper respiratory disease of equids, strangles, characterised by pyrexia, lymphadenopathy and mucopurulent nasal discharge. Strangles was first reported over 750 years ago... Read More about Advances in the understanding, detection and management of equine strangles.

Tilapia Lake Virus Vaccine Development: A Review on the Recent Advances (2023)
Journal Article

Tilapia tilapinevirus (or tilapia lake virus, TiLV) is a recently emerging virus associated with a novel disease affecting and decimating tilapia populations around the world. Since its initial identification, TiLV has been reported in 17 countries,... Read More about Tilapia Lake Virus Vaccine Development: A Review on the Recent Advances.

Therapeutic Phage Display-Derived Single-Domain Antibodies for Pandemic Preparedness (2023)
Journal Article

Driven by necessity, the COVID-19 pandemic caused by SARS-CoV-2 has accelerated the development and implementation of new vaccine platforms and other viral therapeutics. Among these is the therapeutic use of antibodies including single-domain antibod... Read More about Therapeutic Phage Display-Derived Single-Domain Antibodies for Pandemic Preparedness.

Seroprevalence of Equine Influenza and Its Associated Risk Factors in Northwest Nigeria (2022)
Journal Article

Equine influenza (EI) is a fast-spreading respiratory disease of equids caused by equine influenza A virus (EIV), often resulting in high morbidity and a huge economic impact on the equine industry globally. In this cross-sectional study to determine... Read More about Seroprevalence of Equine Influenza and Its Associated Risk Factors in Northwest Nigeria.

Emergence of equine influenza virus H3Nx Florida clade 2 in Arabian racehorses in Egypt (2022)
Journal Article

Background Equine influenza is an important cause of respiratory disease in equids. The causative virus; EIV, is highly variable and can evolve by accumulation of mutations, particularly in the haemagglutinin (HA) gene. Currently, H3N8 is the sole... Read More about Emergence of equine influenza virus H3Nx Florida clade 2 in Arabian racehorses in Egypt.

Epidemiology of equine influenza in the Maghreb area (2022)
Journal Article

Equine influenza (EI) is one of the most contagious respiratory infections in horses, donkeys and mules, caused by equine influenza A virus (EIV). It remains a disease with a strong economic stake for the equine industry. This review focuses on the e... Read More about Epidemiology of equine influenza in the Maghreb area.

An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation (2022)
Journal Article

Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine stu... Read More about An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation.

Inference for a spatio-temporal model with partial spatial data: African horse sickness virus in Morocco (2022)
Journal Article

African horse sickness virus (AHSV) is a vector-borne virus spread by midges (Culicoides spp.). The virus causes African horse sickness (AHS) disease in some species of equid. AHS is endemic in parts of Africa, previously emerged in Europe and in 2... Read More about Inference for a spatio-temporal model with partial spatial data: African horse sickness virus in Morocco.

Gene Expression Profile Induced by Two Different Variants of Street Rabies Virus in Mice (2022)
Journal Article

Pathogenicity and pathology of rabies virus (RABV) varies according to the variant, but the mechanisms are not completely known. In this study, gene expression profile in brains of mice experimentally infected with RABV isolated from a human case of... Read More about Gene Expression Profile Induced by Two Different Variants of Street Rabies Virus in Mice.

Development of Plant-Based Vaccines for Prevention of Avian Influenza and Newcastle Disease in Poultry (2022)
Journal Article

Viral diseases, including avian influenza (AI) and Newcastle disease (ND), are an important cause of morbidity and mortality in poultry, resulting in significant economic losses. Despite the availability of commercial vaccines for the major viral dis... Read More about Development of Plant-Based Vaccines for Prevention of Avian Influenza and Newcastle Disease in Poultry.

Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search (2022)
Journal Article

African horse sickness (AHS) is a vector-borne disease transmitted by Culicoides spp., endemic to sub-Saharan Africa. There have been many examples of historic and recent outbreaks in the Middle East, Asia and Europe. However, not much is known about... Read More about Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search.

Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus (2021)
Journal Article

Four undescribed cucurbitacins, designated as petiolaticins A–D, and four known cucurbitacins were isolated from the bark and leaves of Elaeocarpus petiolatus (Jack) Wall. Their chemical structures were elucidated based on detailed analyses of the NM... Read More about Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus.

Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes (2021)
Journal Article

Bluetongue (BT) is a severe and economically important disease of ruminants that is widely distributed around the world, caused by the bluetongue virus (BTV). More than 28 different BTV serotypes have been identified in serum neutralisation tests (SN... Read More about Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes.

A Scoping Review of West Nile Virus Seroprevalence Studies among African Equids (2021)
Journal Article

West Nile virus (WNV) is an emerging and re-emerging zoonotic flavivirus first identified in and endemic to Africa. The virus is transmitted between birds by biting mosquitoes, with equids and humans being incidental hosts. The majority of infected i... Read More about A Scoping Review of West Nile Virus Seroprevalence Studies among African Equids.