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Therapeutic Phage Display-Derived Single-Domain Antibodies for Pandemic Preparedness

Daly, Janet M.; Lim, Theam Soon; Gough, Kevin C.


Professor of Viral Zoonoses

Theam Soon Lim

Professor of Biochemistry and Pathology


Driven by necessity, the COVID-19 pandemic caused by SARS-CoV-2 has accelerated the development and implementation of new vaccine platforms and other viral therapeutics. Among these is the therapeutic use of antibodies including single-domain antibodies, in particular the camelid variable heavy-chain fragment (VHH). Such therapies can provide a critical interim intervention when vaccines have not yet been developed for an emerging virus. It is evident that an increasing number of different viruses are emerging and causing epidemics and pandemics with increasing frequency. It is therefore imperative that we capitalize on the experience and knowledge gained from combatting COVID-19 to be better prepared for the next pandemic.


Daly, J. M., Lim, T. S., & Gough, K. C. (2023). Therapeutic Phage Display-Derived Single-Domain Antibodies for Pandemic Preparedness. Antibodies, 12(1), Article 7.

Journal Article Type Article
Acceptance Date Jan 9, 2023
Online Publication Date Jan 14, 2023
Publication Date Jan 14, 2023
Deposit Date Jan 9, 2023
Publicly Available Date Jan 14, 2023
Journal Antibodies
Electronic ISSN 2073-4468
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 12
Issue 1
Article Number 7
Keywords VHH, single-domain antibody, virus, therapeutic
Public URL
Publisher URL


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