Comparative transcriptome analysis of spleen of Newcastle Disease Virus (NDV) infected chicken and Japanese quail: a potential role of NF-κβ pathway activation in NDV resistance

Panner Selvam, Manesh Kumar; Kanagaraj, Vijayrani; Kathaperumal, Kumanan; Nissly, Ruth H.; Daly, Janet M.; Kuchipudi, Suresh V.

Abstract

Newcastle disease (ND) affects a few hundred avian species including chicken and several species of domestic and wild birds. The clinical outcome of Newcastle disease virus (NDV) infection ranges from mild to severe fatal disease depending on the NDV pathotype and the host species involved. Japanese quails serve as natural reservoirs of NDV and play important role in NDV epidemiology. While infection of chicken with velogenic NDV results in severe often fatal illness, the same infection in Japanese quails results in inapparent infection. The molecular basis of this contrasting clinical outcomes of NDV infection is not yet clearly known. We compared global gene expression in spleen of chicken and Japanese quails infected with lentogenic and velogenic NDVs. We found contrasting regulation of key genes associated with NF-κB pathway and T-cell activation between chicken and Japanese quails. Our data suggests association of NDV resistance in Japanese quails to activation of NF-κB pathway and T cell proliferation.

Citation

Panner Selvam, M. K., Kanagaraj, V., Kathaperumal, K., Nissly, R. H., Daly, J. M., & Kuchipudi, S. V. (2023). Comparative transcriptome analysis of spleen of Newcastle Disease Virus (NDV) infected chicken and Japanese quail: a potential role of NF-κβ pathway activation in NDV resistance. VirusDisease, 34(3), 402-409. https://doi.org/10.1007/s13337-023-00833-y

• Journal Article Type: Article
• Acceptance Date: Jul 18, 2023
• Online Publication Date: Aug 9, 2023
• Publication Date: 2023-09
• Deposit Date: Aug 15, 2023
• Publicly Available Date: Aug 10, 2024
• Journal: VirusDisease
• Electronic ISSN: 2347-3517
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Volume: 34
• Issue: 3
• Pages: 402-409
• DOI: https://doi.org/10.1007/s13337-023-00833-y
• Keywords: Global gene expression, NGS, Japanese quail, Newcastle Disease Virus, Chicken
• Public URL: https://nottingham-repository.worktribe.com/output/24404062
• Publisher URL: https://link.springer.com/article/10.1007/s13337-023-00833-y
• Additional Information: This version of the article has been accepted for publication, after peer review (when applicable) but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s13337-023-00833-y