The value of a comparative approach with equine vaccine development for the development of human influenza DNA vaccines

Abdelkhalek, Ahmed F.; Daly, Janet M.

Abstract

Abstract: A comparative medicine approach, whereby similarities and differences in biology between human and veterinary species are used to enhance understanding for the benefit of both, is highly relevant to the development of viral vaccines. Human and equine influenza share many similarities in pathogenesis and immune responses. The DNA vaccine approach offers potential advantages for responding rapidly and effectively to outbreaks or pandemics in both humans and animals, especially in under-resourced regions. The European and American vaccine regulatory authorities require demonstration of vaccine efficacy in animal models. However, mice, the most widely used model, are not naturally infected with influenza viruses, resulting in different pathobiology. Additionally, mice as a model for DNA vaccine testing appear to overestimate the humoral immune response compared to other mammalian species. In this review, we propose that testing of DNA vaccines against influenza type A viruses (and other shared pathogens) in the horse can provide valuable knowledge for the development of human DNA vaccines.

Citation

Abdelkhalek, A. F., & Daly, J. M. (2024). The value of a comparative approach with equine vaccine development for the development of human influenza DNA vaccines. Zoonoses, 4(4), 245-258. https://doi.org/10.3390/zoonoticdis4040021

• Journal Article Type: Article
• Acceptance Date: Oct 11, 2024
• Online Publication Date: Oct 14, 2024
• Publication Date: Oct 14, 2024
• Deposit Date: Oct 18, 2024
• Publicly Available Date: Oct 18, 2024
• Journal: Zoonotic Diseases
• Print ISSN: 2737-7466
• Electronic ISSN: 2737-7474
• Publisher: Compuscript
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 4
• Pages: 245-258
• DOI: https://doi.org/10.3390/zoonoticdis4040021
• Keywords: DNA vaccines; animal model; equine; influenza virus, immune system
• Public URL: https://nottingham-repository.worktribe.com/output/40588567
• Publisher URL: https://www.mdpi.com/2813-0227/4/4/21