Luke A. McLinden
Advances in the understanding, detection and management of equine strangles
McLinden, Luke A.; Freeman, Sarah L.; Daly, Janet; Blanchard, Adam; Kemp‐Symonds, Jeremy G.; Waller, Andrew
Authors
SARAH FREEMAN sarah.freeman@nottingham.ac.uk
Professor of Veterinary Surgery
JANET DALY janet.daly@nottingham.ac.uk
Professor of Viral Zoonoses
ADAM BLANCHARD ADAM.BLANCHARD@NOTTINGHAM.AC.UK
Associate Professor
Jeremy G. Kemp‐Symonds
Andrew Waller
Abstract
Streptococcus equi subspecies equi (S. equi) is the causative organism of the upper respiratory disease of equids, strangles, characterised by pyrexia, lymphadenopathy and mucopurulent nasal discharge. Strangles was first reported over 750 years ago and continues to be of significance in equine populations across the globe. This review discusses how S. equi has adapted, the clinical manifestation of strangles, and how clinicians and caregivers can tackle the disease in the future. S. equi evolved from the commensal, and occasionally opportunistic pathogen, Streptococcus equi subspecies zooepidemicus refining its capabilities as it became host restricted. The success of S. equi can be attributed to its ability to cause both acute and persistent infection, the latter occurring in about 10% of those infected. In this carrier state, S. equi persists in the guttural pouch without causing clinical signs, intermittently shedding into the environment, and encountering naïve animals. Insight into the S. equi genome and lifestyle has led to advances in diagnostic assays and the development of a safe and efficacious recombinant-fusion vaccine, giving clinicians and caregivers the tools to better combat this infection. Alongside rigorous biosecurity protocols and pragmatic control measures such as screening new arrivals for exposure and carrier status, these new technologies demonstrate that strangles can be an increasingly preventable infection.
Citation
McLinden, L. A., Freeman, S. L., Daly, J., Blanchard, A., Kemp‐Symonds, J. G., & Waller, A. (2023). Advances in the understanding, detection and management of equine strangles. Equine Veterinary Education, 35(12), 662-672. https://doi.org/10.1111/eve.13845
Journal Article Type | Article |
---|---|
Acceptance Date | May 17, 2023 |
Online Publication Date | Jun 28, 2023 |
Publication Date | 2023-12 |
Deposit Date | Aug 3, 2023 |
Publicly Available Date | Aug 3, 2023 |
Journal | Equine Veterinary Education |
Print ISSN | 0957-7734 |
Electronic ISSN | 2042-3292 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 35 |
Issue | 12 |
Pages | 662-672 |
DOI | https://doi.org/10.1111/eve.13845 |
Keywords | horse, Streptococcus equi, strangles |
Public URL | https://nottingham-repository.worktribe.com/output/22449902 |
Publisher URL | https://beva.onlinelibrary.wiley.com/doi/full/10.1111/eve.13845 |
Files
Equine Veterinary Education - 2023 - McLinden - Advances in the understanding detection and management of equine strangles
(1.1 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
Scoping review of end-of-life decision-making models used in dogs, cats and equids
(2022)
Journal Article
A scoping review of the current evidence on treatment and outcomes following synovial sepsis
(2021)
Journal Article
Owners' Knowledge and Approaches to Colic in Working Equids in Honduras
(2021)
Journal Article
Quality Improvement: origins, purpose and the future for veterinary practice
(2021)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search