All Outputs (87)

Interventions for basal cell carcinoma of the skin (2020)
Journal Article

Background: Basal cell carcinoma (BCC) is the commonest cancer affecting white-skinned individuals, and worldwide incidence is increasing. Although rarely fatal, BCC is associated with significant morbidity and costs. First-line treatment is usually... Read More about Interventions for basal cell carcinoma of the skin.

An economic evaluation of the randomized controlled trial of topical corticosteroid and home-based narrowband ultraviolet B for active and limited vitiligo (the HI-Light Vitiligo Trial)* (2020)
Journal Article

Background: Economic evidence for vitiligo treatments is absent. Objectives: To determine the cost-effectiveness of (i) handheld narrowband ultraviolet B (NB-UVB) and (ii) a combination of topical corticosteroid (TCS) and NB-UVB compared with TCS alo... Read More about An economic evaluation of the randomized controlled trial of topical corticosteroid and home-based narrowband ultraviolet B for active and limited vitiligo (the HI-Light Vitiligo Trial)*.

Randomised controlled trial of topical corticosteroid and home?based narrowband UVB for active and limited vitiligo: results of the HI?Light Vitiligo trial (2020)
Journal Article

Background Evidence for the effectiveness of vitiligo treatments is limited. Objectives To determine effectiveness of (a) hand‐held narrowband‐UVB (NB‐UVB) and (b) combination of potent topical corticosteroid (TCS) and NB‐UVB compared to TCS, fo... Read More about Randomised controlled trial of topical corticosteroid and home?based narrowband UVB for active and limited vitiligo: results of the HI?Light Vitiligo trial.

Personalised prediction of daily eczema severity scores using a mechanistic machine learning model (2020)
Journal Article

Background Atopic dermatitis (AD) is a chronic inflammatory skin disease with periods of flares and remission. Designing personalised treatment strategies for AD is challenging, given the apparent unpredictability and large variation in AD symptom... Read More about Personalised prediction of daily eczema severity scores using a mechanistic machine learning model.

Quality and reporting completeness of systematic reviews and meta-analyses in dermatology (2020)
Journal Article

Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial (2020)
Journal Article

Background Failure to collect outcome data in randomised trials can result in bias and loss of statistical power. Further evaluations of strategies to increase retention are required. We assessed the effectiveness of two strategies for retention in... Read More about Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial.

Prevention of Atopic Dermatitis (2020)
Journal Article

Despite advances in atopic dermatitis (AD) treatments, research into AD prevention has been slow. Systematic reviews of prevention strategies promoting exclusive and prolonged breastfeeding, or interventions that reduce ingested or airborne allergens... Read More about Prevention of Atopic Dermatitis.

Future of evidence ecosystem series: 3. From an evidence synthesis ecosystem to an evidence ecosystem (2020)
Journal Article

The “one-off” approach of systematic reviews is no longer sustainable; we need to move toward producing “living” evidence syntheses (i.e., comprehensive, based on rigorous methods, and up-to-date). This implies rethinking the evidence synthesis ecosy... Read More about Future of evidence ecosystem series: 3. From an evidence synthesis ecosystem to an evidence ecosystem.

Future of evidence ecosystem series: 2. Current opportunities and need for better tools and methods (2020)
Journal Article

To become user-driven and more useful for decision-making, the current evidence synthesis ecosystem requires significant changes (Paper 1.Future of evidence ecosystem series). Reviewers have access to new sources of data (clinical trial registries, p... Read More about Future of evidence ecosystem series: 2. Current opportunities and need for better tools and methods.

Future of evidence ecosystem series: 1. Introduction — Evidence synthesis ecosystem needs dramatic change (2020)
Journal Article

To make healthcare decisions, patients, clinicians, clinical practice guideline developers, researchers, policy-makers and health system managers need a comprehensive, critical, accessible, actionable and up-to-date synthesis of all available evidenc... Read More about Future of evidence ecosystem series: 1. Introduction — Evidence synthesis ecosystem needs dramatic change.

An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge (2020)
Journal Article

© 2020 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd. Background: Food allergy diagnosis in clinical studies can be challenging. Oral food challenges (OFC) are time-consuming, carry some risk and may, therefore,... Read More about An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge.

Algorithm based smartphone apps to assess risk of skin cancer in adults: systematic review of diagnostic accuracy studies (2020)
Journal Article

© Published by the BMJ Publishing Group Limited. Objective To examine the validity and findings of studies that examine the accuracy of algorithm based smartphone applications ("apps") to assess risk of skin cancer in suspicious skin lesions. Design... Read More about Algorithm based smartphone apps to assess risk of skin cancer in adults: systematic review of diagnostic accuracy studies.

A behaviour change package to prevent hand dermatitis in nurse working in the National Health Service: results of a cluster randomised controlled trial (2020)
Journal Article

Background Occupational hand dermatitis poses a serious risk for nurses. Objectives To evaluate the clinical and cost?effectiveness of a complex intervention in reducing the prevalence of hand dermatitis in nurses Trial design Cluster random... Read More about A behaviour change package to prevent hand dermatitis in nurse working in the National Health Service: results of a cluster randomised controlled trial.

F1000Prime Recommendation of Genetic ancestry does not explain increased atopic dermatitis susceptibility or worse disease control among African American subjects in 2 large US cohorts. (2019)
Other

Best emollients for eczema (BEE) – comparing four types of emollients in children with eczema: protocol for randomised trial and nested qualitative study (2019)
Journal Article

Introduction Atopic dermatitis/eczema affects around 20% of children and is characterised by inflamed, dry, itchy skin. Guidelines recommend ‘leave-on’ emollients that are applied directly to the skin to add or trap moisture and used regularly, they... Read More about Best emollients for eczema (BEE) – comparing four types of emollients in children with eczema: protocol for randomised trial and nested qualitative study.

Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016 (2019)
Journal Article

Dermatofibrosarcoma protuberans is a rare soft tissue tumour with a very low (less than 0.5%) rate of metastasis. Rates of re-excision and recurrence were determined using data from the Netherlands Cancer Registry between 1989 and 2016. Of the 1,890... Read More about Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016.

Ultrasound, CT, MRI, or PET-CT for staging and re-staging of adults with cutaneous melanoma (2019)
Journal Article

© 2019 The Cochrane Collaboration. Background Melanoma is one of the most aggressive forms of skin cancer, with the potential to metastasise to other parts of the body via the lymphatic system and the bloodstream. Melanoma accounts for a small percen... Read More about Ultrasound, CT, MRI, or PET-CT for staging and re-staging of adults with cutaneous melanoma.

Different strategies for using topical corticosteroids in people with eczema (2019)
Journal Article

© 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To establish the effectiveness and safety of different ways of using topical corticoster... Read More about Different strategies for using topical corticosteroids in people with eczema.

Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts (2019)
Journal Article

Background Topical corticosteroids (CS) are commonly used to treat inflammatory skin conditions including eczema and psoriasis. While topical CS package inserts describe hyperglycaemia and glycosuria as adverse drug reactions, it is unclear whether... Read More about Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts.

Navigating the landscape of core outcome set development in dermatology (2019)
Journal Article

© 2019 American Academy of Dermatology, Inc. The development of core outcome sets (COSs; ie, a minimum set of core outcomes that should be measured and reported in all trials or in clinical practice for a specific condition) in dermatology is increas... Read More about Navigating the landscape of core outcome set development in dermatology.