Charlotte B. van Lee
Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016
van Lee, Charlotte B.; Kan, Wilner Christopher; Gran, Sonia; Mooyaart, Antien; Mureau, Marc A.M.; Williams, Hywel; Matin, Rubeta; van den Bos, Renate; Hollestein, Loes M.
Authors
Wilner Christopher Kan
SONIA GRAN SONIA.GRAN@NOTTINGHAM.AC.UK
Associate Professor
Antien Mooyaart
Marc A.M. Mureau
HYWEL WILLIAMS HYWEL.WILLIAMS@NOTTINGHAM.AC.UK
Professor of Dermato-Epidemiology
Rubeta Matin
Renate van den Bos
Loes M. Hollestein
Abstract
Dermatofibrosarcoma protuberans is a rare soft tissue tumour with a very low (less than 0.5%) rate of metastasis. Rates of re-excision and recurrence were determined using data from the Netherlands Cancer Registry between 1989 and 2016. Of the 1,890 instances of dermatofibrosarcoma protuberans included, 87% were treated with excision, 4% with Mohs micrographic surgery, and 9% otherwise or unknown. Linked pathology data were retrieved for 1,677 patients. Half of all excisions (847/1,644) were incomplete and 29% (192/622) of all re-excisions were incomplete. The cumulative incidence of a recurrence was 7% (95% confidence interval (CI) 6–8) during a median followup of 11 years (interquartile range (IQR) 6–17). After
Mohs micrographic surgery (n = 34), there were no recurrences
during a median follow-up of 4 years (IQR 3–6). Due to the high rate of incomplete excisions and recurrences after excision, this study supports the European guideline, which recommends treating dermatofibrosarcoma protuberans with Mohs micrographic surgery in order to decrease the rate of recurrence.
Citation
van Lee, C. B., Kan, W. C., Gran, S., Mooyaart, A., Mureau, M. A., Williams, H., …Hollestein, L. M. (2019). Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016. Acta Dermato-Venereologica, 99(12), 1160-1165. https://doi.org/10.2340/00015555-3287
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 12, 2019 |
Online Publication Date | Aug 13, 2019 |
Publication Date | Aug 13, 2019 |
Deposit Date | Oct 1, 2019 |
Publicly Available Date | Oct 1, 2019 |
Journal | Acta Dermato Venereologica |
Print ISSN | 0001-5555 |
Electronic ISSN | 1651-2057 |
Publisher | Society for Publication of Acta Dermato-Venereologica |
Peer Reviewed | Peer Reviewed |
Volume | 99 |
Issue | 12 |
Pages | 1160-1165 |
DOI | https://doi.org/10.2340/00015555-3287 |
Keywords | dermatofibrosarcoma protuberans; recurrence; surgical excision; histological clearance; Mohs micrographic surgery |
Public URL | https://nottingham-repository.worktribe.com/output/2726590 |
Publisher URL | https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-3287 |
Contract Date | Oct 1, 2019 |
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Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/
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