Yuki M.F. Andersen
Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts
Andersen, Yuki M.F.; Egeberg, Alexander; Ban, Lu; Gran, Sonia; Williams, Hywel C.; Francis, Nick A.; Knop, Filip K.; Gislason, Gunnar H.; Skov, Lone; Thyssen, Jacob P.
Authors
Alexander Egeberg
Lu Ban
SONIA GRAN SONIA.GRAN@NOTTINGHAM.AC.UK
Associate Professor
HYWEL WILLIAMS HYWEL.WILLIAMS@NOTTINGHAM.AC.UK
Professor of Dermato-Epidemiology
Nick A. Francis
Filip K. Knop
Gunnar H. Gislason
Lone Skov
Jacob P. Thyssen
Abstract
Background
Topical corticosteroids (CS) are commonly used to treat inflammatory skin conditions including eczema and psoriasis. While topical CS package inserts describe hyperglycaemia and glycosuria as adverse drug reactions, it is unclear whether topical CS use in real life is also associated with an increased risk of type 2 diabetes (T2D).
Methods
Two matched case-control studies and one cohort study were conducted using routinely collected healthcare data from Denmark the UK. A total of 115,218 and 54,944 adults were identified as cases with new onset T2D in the Danish and UK case-control study, respectively. For the Danish cohort study, 2,689,473 adults were included. The main exposure was topical CS and the outcome was incident T2D.
Results
Topical CS was significantly associated with T2D in the Danish (adjusted OR 1ꞏ35; 95% CI 1ꞏ33- 1ꞏ38) and UK (adjusted OR 1ꞏ23; 95% CI 1ꞏ19-1ꞏ27) case-control studies. Individuals who were exposed to topical CS had significantly increased risk of incident T2D (adjusted HR 1ꞏ27; 95% CI 1ꞏ26-1ꞏ29). We observed significant dose-response relationships between T2D and increasing potency of topical CS in the two Danish studies. The results were consistent across all sensitivity analyses.
Conclusions
We found a positive association between topical CS prescribing and incident T2D in Danish and UK adult populations. Clinicians should be cognizant of possible diabetogenic effects of potent topical CS.
Citation
Andersen, Y. M., Egeberg, A., Ban, L., Gran, S., Williams, H. C., Francis, N. A., …Thyssen, J. P. (2019). Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts. Diabetes Care, 42(6), 1095-1103. https://doi.org/10.2337/dc18-2158
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 7, 2019 |
Online Publication Date | Apr 1, 2019 |
Publication Date | Jun 1, 2019 |
Deposit Date | Mar 13, 2019 |
Publicly Available Date | Apr 2, 2020 |
Journal | Diabetes Care |
Print ISSN | 0149-5992 |
Electronic ISSN | 1935-5548 |
Publisher | American Diabetes Association |
Peer Reviewed | Peer Reviewed |
Volume | 42 |
Issue | 6 |
Pages | 1095-1103 |
DOI | https://doi.org/10.2337/dc18-2158 |
Public URL | https://nottingham-repository.worktribe.com/output/1635334 |
Publisher URL | http://care.diabetesjournals.org/content/42/6/1095 |
Contract Date | Mar 13, 2019 |
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