All Outputs (8)

Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study (2015)
Journal Article
McKeever, T. M., Hearson, G., Housley, G., Reynolds, C., Kinnear, W., Harrison, T. W., …Shaw, D. E. (2016). Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study. Thorax, 71(3), 210-215. https://doi.org/10.1136/thoraxjnl-2015-207573

Introduction: Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are more difficult to obtain than venous. We assessed... Read More about Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study.

Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma (2015)
Journal Article
Lilburn, D. M., Tatler, A. L., Six, J. S., Lesbats, C., Habgood, A., Porte, J., …Meersmann, T. (2015). Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma. Magnetic Resonance in Medicine, 76(4), 1224-1235. https://doi.org/10.1002/mrm.26003

© 2015 The Authors. Wiley Periodicals, Inc. Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independen... Read More about Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma.

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort (2015)
Journal Article
Shaw, D. E., Sousa, A. R., Fowler, S. J., Fleming, L. J., Roberts, G., Corfield, J., …Chung, K. F. (2015). Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. European Respiratory Journal, 46(5), 1308-1321. https://doi.org/10.1183/13993003.00779-2015

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach. This c... Read More about Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.

Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema (2015)
Journal Article
Lilburn, D. M., Lesbats, C., Six, J. S., Dubuis, E., Yew-Booth, L., Shaw, D. E., …Meersmann, T. (2015). Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema. Interface, 12(107), Article 20150192. https://doi.org/10.1098/rsif.2015.0192

© 2015 The Authors. Hyperpolarized 83Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate with surface-to-volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is... Read More about Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema.

A review of standard pharmacological therapy for adult asthma - Steps 1 to 5 (2015)
Journal Article
Patel, M. D. K., & Shaw, D. E. (2015). A review of standard pharmacological therapy for adult asthma - Steps 1 to 5. Chronic Respiratory Disease, 12(2), https://doi.org/10.1177/1479972315573529

The aim of pharmacological therapy for asthma is to improve symptoms and lung function and minimise the risk of asthma attacks. The intensity of treatment is based on the level of asthma control and the potential risk of future deterioration. In th... Read More about A review of standard pharmacological therapy for adult asthma - Steps 1 to 5.

A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA) (2015)
Journal Article
Hodgson, D., Anderson, J., Reynolds, C., Meakin, G., Bailey, H., Pavord, I., …Harrison, T. W. (2015). A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA). Thorax, 70(6), 559-565. https://doi.org/10.1136/thoraxjnl-2014-206481

Background: Some patients with refractory asthma have evidence of uncontrolled eosinophilic inflammation in the distal airways. While traditional formulations of inhaled steroids settle predominantly in the large airways, newer formulations with an e... Read More about A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA).

A survey-based cross-sectional study of doctors’ expectations and experiences of non-technical skills for out of hours work (2015)
Journal Article
Brown, M., Shaw, D. E., Sharples, S., Le Jeune, I., & Blakey, J. (2015). A survey-based cross-sectional study of doctors’ expectations and experiences of non-technical skills for out of hours work. BMJ Open, 5(2), Article e006102. https://doi.org/10.1136/bmjopen-2014-006102

Objectives: The skill set required for junior doctors to work efficiently and safely Out of Hours (OoH) in hospitals has not been established. This is despite the OoH period representing 75% of the year and it being the time of highest mortality. We... Read More about A survey-based cross-sectional study of doctors’ expectations and experiences of non-technical skills for out of hours work.

The use of ?2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis (2015)
Journal Article
Patel, M., Pilcher, J., Hancox, R. J., Sheahan, D., Pritchard, A., Braithwaite, I., …Beasley, R. (2015). The use of β2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis. npj Primary Care Respiratory Medicine, 25, 1-9. https://doi.org/10.1038/npjpcrm.2014.99

Background: Patterns of inhaled β2-agonist therapy use during severe asthma exacerbations before hospital attendance are poorly understood. Aims: To assess β2-agonist use prior to hospital attendance. Methods: We undertook an exploratory pos... Read More about The use of ?2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis.