All Outputs (101)

The differential effects of azithromycin on the airway epithelium in vitro and in vivo (2016)
Journal Article
Slater, M., Torr, E., Harrison, T. W., Forrester, D. L., Knox, A., Shaw, D. E., & Sayers, I. (2016). The differential effects of azithromycin on the airway epithelium in vitro and in vivo. Physiological Reports, 4(18), 1-15. https://doi.org/10.14814/phy2.12960

Macrolides including azithromycin (AZM) can improve clinical symptoms in asthma regardless of infection status. The mechanisms underlying these benefi- cial effects are yet to be elucidated. The aim of this study was to determine the effect of AZM on... Read More about The differential effects of azithromycin on the airway epithelium in vitro and in vivo.

Step 4: stick or twist? A review of asthma therapy (2016)
Journal Article
Slater, M. G., Pavord, I. D., & Shaw, D. E. (2016). Step 4: stick or twist? A review of asthma therapy. BMJ Open Respiratory Research, 3(1), 1-7. https://doi.org/10.1136/bmjresp-2016-000143

Many people with asthma do not achieve disease control, despite bronchodilators and inhaled corticosteroid therapy. People with uncontrolled asthma are at higher risk of an asthma attack and death, with mortality rates estimated at 1000 deaths/ year... Read More about Step 4: stick or twist? A review of asthma therapy.

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED (2016)
Journal Article
Khuo, C. S., Pavlidis, S., Loza, M., Baribaud, F., Rowe, A., Pandis, I., …Chung, K. F. (2017). A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED. American Journal of Respiratory and Critical Care Medicine, 195(4), https://doi.org/10.1164/rccm.201512-2452OC

Rationale and objectives: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. Methods: The transcriptome from bronchial biop... Read More about A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED.

Evaluation of the PPAR-y agonist pioglitazone in mild asthma: A double-blind randomized controlled trial (2016)
Journal Article
Anderson, J., Mortimer, K., Pang, L., Smith, K., Bailey, H., Hodgson, D., …Harrison, T. W. (2016). Evaluation of the PPAR-y agonist pioglitazone in mild asthma: A double-blind randomized controlled trial. PLoS ONE, 11(8), 1-15. https://doi.org/10.1371/journal.pone.0160257

Background Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a nuclear receptor that modulates inflammation in models of asthma. To determine whether pioglitazone improves measures of asthma control and airway inflammation, we performed... Read More about Evaluation of the PPAR-y agonist pioglitazone in mild asthma: A double-blind randomized controlled trial.

Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells (2016)
Journal Article
Torr, E., Heath, M., Mee, M., Shaw, D. E., Sharp, T. V., & Sayers, I. (2016). Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells. Physiological Reports, 4(16), 1-14. https://doi.org/10.14814/phy2.12847

The airway epithelium is altered in respiratory disease and is thought to contribute to disease aetiology. A caveat to disease research is that the technique of isolation of bronchial epithelial cells from patients is invasive and cells have a limite... Read More about Expression of polycomb protein BMI-1 1 maintains the plasticity of basal 2 bronchial epithelial cells.

Assessment of a rapid liquid-based cytology method for measuring sputum cell counts (2016)
Journal Article
Martin, M., Lee, H., Meakin, G., Green, A., Simms, R., Reynolds, C., …Harrison, T. W. (in press). Assessment of a rapid liquid-based cytology method for measuring sputum cell counts. Thorax, https://doi.org/10.1136/thoraxjnl-2016-208817

Differential sputum cell counting is not widely available despite proven clinical utility in the management of asthma. We compared eosinophil counts obtained using liquid-based cytology (LBC), a routine histopathological processing method, and the cu... Read More about Assessment of a rapid liquid-based cytology method for measuring sputum cell counts.

A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation (2016)
Journal Article
Williams, N. C., Johnson, M. A., Shaw, D. E., Spendlove, I., Vulevic, J., Sharpe, G. R., & Hunter, K. A. (2016). A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation. British Journal of Nutrition, 116(5), 798-804. https://doi.org/10.1017/S0007114516002762

Gut microbes have a substantial influence on systemic immune function and allergic sensitisation. Manipulation of the gut microbiome through prebiotics may provide a potential strategy to influence the immunopathology of asthma. This study investigat... Read More about A prebiotic galactooligosaccharide mixture reduces severity of hyperpnoea-induced bronchoconstriction and markers of airway inflammation.

See I told you I was taking it! - attitudes of adolescents with asthma towards a device monitoring their inhaler use: Implications for future design (2016)
Journal Article
Howard, S., Lang, A. R., Sharples, S., & Shaw, D. E. (2017). See I told you I was taking it! - attitudes of adolescents with asthma towards a device monitoring their inhaler use: Implications for future design. Applied Ergonomics, 58, 224-237. https://doi.org/10.1016/j.apergo.2016.06.018

Adherence to treatment in asthma is often poor, particularly in adolescents and children where the condition is most prevalent. Electronic monitoring devices have shown potential for improving inhaler use, yet little research has considered the attit... Read More about See I told you I was taking it! - attitudes of adolescents with asthma towards a device monitoring their inhaler use: Implications for future design.

Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma (2016)
Journal Article
Malkar, A., Wilson, E., Harrison, T., Shaw, D. E., & Creaser, C. (in press). Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma. Analytical Methods, 8(27), 5407-5413. https://doi.org/10.1039/C6AY00938G

Current clinical tests employed to diagnose asthma are inaccurate and limited by their invasive nature. New metabolite profiling technologies offer an opportunity to improve asthma diagnosis using non-invasive sampling. A rapid analytical method for... Read More about Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma.

Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study (2016)
Journal Article
Zaccardi, F., Davies, M. J., Dhalwani, N. N., Webb, D. R., Housley, G., Shaw, D. E., …Khunti, K. (2016). Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study. Lancet Diabetes and Endocrinology, 4(8), 677-685. https://doi.org/10.1016/S2213-8587%2816%2930091-2

Background Studies in the USA and Canada have reported increasing or stable rates of hospital admissions for hypoglycaemia. Some data from small studies are available for other countries. We aimed to gather information about long-term trends in ho... Read More about Trends in hospital admissions for hypoglycaemia in England: a retrospective, observational study.

The utility of exhaled nitric oxide in patients with suspected asthma (2016)
Journal Article
Martin, M., Wilson, E., Gerrard-Tarpey, W., Meakin, G., Hearson, G., McKeever, T., …Harrison, T. (2016). The utility of exhaled nitric oxide in patients with suspected asthma. Thorax, 71(6), https://doi.org/10.1136/thoraxjnl-2015-208014

The value of FENO measurements in patients with symptoms suggestive of asthma is unclear. We performed an observational study to assess the ability of FENO to diagnose asthma and to predict response to inhaled corticosteroids (ICS). Our findings sugg... Read More about The utility of exhaled nitric oxide in patients with suspected asthma.

Effect of smoking status on the efficacy of the SMART regimen in high risk asthma (2016)
Journal Article
Pilcher, J., Patel, M., Reddel, H. K., Pritchard, A., Black, P., Shaw, D., …Beasley, R. (2016). Effect of smoking status on the efficacy of the SMART regimen in high risk asthma. Respirology, 21(5), 858-866. https://doi.org/10.1111/resp.12740

Background and objective: The optimal management of people with asthma with a significant smoking history is uncertain. The aim of this study was to determine whether the efficacy/safety profile of single combination inhaled corticosteroid (ICS)/long... Read More about Effect of smoking status on the efficacy of the SMART regimen in high risk asthma.

The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma (2016)
Journal Article
Ketelaar, M. E., Nawijn, M. C., Shaw, D. E., Koppelman, G. H., & Sayers, I. (2016). The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma. Clinical and Experimental Allergy, 46(6), 884-887. https://doi.org/10.1111/cea.12718

Background Interleukin-33 (IL-33) has been subject of extensive study in the context of inflammatory disorders, particularly in asthma. Many human biological samples, including serum, have been used to determine the protein levels of IL-33, aiming t... Read More about The challenge of measuring IL-33 in serum using commercial ELISA: lessons from asthma.

The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial (2016)
Journal Article
Hodgson, D., Anderson, J., Reynolds, C., Oborne, J., Meakin, G., Bailey, H., …Harrison, T. (2016). The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial. Chest, 149(4), 1052-1060. https://doi.org/10.1016/j.chest.2015.12.036

Background Chronic cough is a common clinical problem worldwide. Although many patients have underlying precipitating conditions such as asthma, gastroesophageal reflux, or rhinitis, many remain symptomatic despite treating these conditions. New a... Read More about The effects of azithromycin in treatment-resistant cough: A randomized, double-blind, placebo-controlled trial.

Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study (2015)
Journal Article
McKeever, T. M., Hearson, G., Housley, G., Reynolds, C., Kinnear, W., Harrison, T. W., …Shaw, D. E. (2016). Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study. Thorax, 71(3), 210-215. https://doi.org/10.1136/thoraxjnl-2015-207573

Introduction: Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are more difficult to obtain than venous. We assessed... Read More about Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study.

Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma (2015)
Journal Article
Lilburn, D. M., Tatler, A. L., Six, J. S., Lesbats, C., Habgood, A., Porte, J., …Meersmann, T. (2015). Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma. Magnetic Resonance in Medicine, 76(4), 1224-1235. https://doi.org/10.1002/mrm.26003

© 2015 The Authors. Wiley Periodicals, Inc. Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independen... Read More about Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma.

Building analytic skills to drive improvements in patient care and organisational decision making: an information analysts’ development programme (2015)
Journal Article
Howard, G., Walker, A. J., Shaw, D. E., & Hatton, J. W. (2015). Building analytic skills to drive improvements in patient care and organisational decision making: an information analysts’ development programme. Clinical Governance, 20(3), https://doi.org/10.1108/CGIJ-07-2015-0021

Purpose This paper briefly outlines a development programme designed to improve the skills of NHS Information Analysts and assesses the extent these skills have been developed. There are significant opportunities for the NHS to utilise information... Read More about Building analytic skills to drive improvements in patient care and organisational decision making: an information analysts’ development programme.

The burden of severe asthma in childhood and adolescence: Results from the paediatric U-BIOPRED cohorts (2015)
Journal Article
Fleming, L., Murray, C., Bansal, A. T., Hashimoto, S., Bisgaard, H., Bush, A., …Roberts, G. (2015). The burden of severe asthma in childhood and adolescence: Results from the paediatric U-BIOPRED cohorts. European Respiratory Journal, 46(5), https://doi.org/10.1183/13993003.00780-2015

U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional and innovative systems biology approaches. A total of 99 school-age children with severe asthma and 81 preschoolers with severe wheeze were compared with 49 schoo... Read More about The burden of severe asthma in childhood and adolescence: Results from the paediatric U-BIOPRED cohorts.

Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort (2015)
Journal Article
Shaw, D. E., Sousa, A. R., Fowler, S. J., Fleming, L. J., Roberts, G., Corfield, J., …Chung, K. F. (2015). Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. European Respiratory Journal, 46(5), 1308-1321. https://doi.org/10.1183/13993003.00779-2015

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach. This c... Read More about Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort.

Navigating in large hospitals (2015)
Conference Proceeding
Hughes, N., Pinchin, J., Brown, M., & Shaw, D. E. (in press). Navigating in large hospitals.

Navigating around large hospitals can be a stressful and time-consuming experience for all users of the hospital infrastructure. Navigation difficulties encountered by patients and visitors can result in missed appointments or simply create a poor im... Read More about Navigating in large hospitals.