Challenges in Enhanced Recovery After Surgery (ERAS) Research
(2024)
Journal Article
All Outputs (151)
Immunohistochemical inflammation in histologically normal gallbladders containing gallstones (2024)
Journal Article
Background: The aim of this study was to establish features of inflammation in histologically normal gallbladders with gallstones and compare the expression of inflammatory markers in acutely and chronically inflamed gallbladders. Methods: Immunohist... Read More about Immunohistochemical inflammation in histologically normal gallbladders containing gallstones.
The effect of diabetes mellitus on perioperative outcomes following colorectal resections: a national cohort study (2024)
Journal Article
Background: Diabetes mellitus is a significant modulator of postoperative outcomes and is an important risk factor in the patient selection process. We aimed to investigate the effect of diabetes mellitus and use of insulin on outcomes following colo... Read More about The effect of diabetes mellitus on perioperative outcomes following colorectal resections: a national cohort study.
Pancreatic neuroendocrine tumours: a comparison of cytological classification systems. (2024)
Journal Article
Aims: Cytological classification systems provide a standardised interpretation framework for reporting cytological specimens. Three well-known classification systems can be applied when reporting pancreatic cytology. This study aimed to compare the a... Read More about Pancreatic neuroendocrine tumours: a comparison of cytological classification systems..
Promoter methylation leads to Hepatocyte Nuclear Factor 4A loss and pancreatic cancer aggressiveness (2024)
Journal Article
Background and Aims Efforts to decode pancreatic ductal adenocarcinoma (PDAC) heterogeneity and the consequent therapeutic selection remains a challenge. We aimed to characterize epigenetically regulated pathways involved in PDAC progression. Met... Read More about Promoter methylation leads to Hepatocyte Nuclear Factor 4A loss and pancreatic cancer aggressiveness.
Exploring the need for reconsideration of trial design in perioperative outcomes research: a narrative review (2024)
Journal Article
“Enhanced recovery after surgery” is a multimodal effort to control perioperative pathophysiology and improve outcome. However, despite advances in perioperative care, postoperative complications and the need for hospitalisation and prolonged recover... Read More about Exploring the need for reconsideration of trial design in perioperative outcomes research: a narrative review.
The clinical significance of hypoalbuminaemia (2024)
Journal Article
Albumin is a relatively small molecule with a radius of 7.5 nm and a molecular weight of 65 kDa. It is the most abundant protein in plasma, accounting for 60–75% of its oncotic pressure. Its concentration in plasma is merely one static measurement re... Read More about The clinical significance of hypoalbuminaemia.
A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms (2024)
Journal Article
The presence of inhibitory immune cells and difficulty in generating activated effector T cells remain obstacles to development of effective cancer vaccines. We designed a vaccine regimen combining human telomerase reverse transcriptase (hTERT) pepti... Read More about A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms.
The impact of prehabilitation on outcomes in frail and high-risk patients undergoing major abdominal surgery: A systematic review and meta-analysis (2024)
Journal Article
Background & aims: Prehabilitation comprises multidisciplinary preoperative interventions including exercise, nutritional optimisation and psychological preparation aimed at improving surgical outcomes. The aim of this systematic review and meta-anal... Read More about The impact of prehabilitation on outcomes in frail and high-risk patients undergoing major abdominal surgery: A systematic review and meta-analysis.
Perioperative pain management for appendicectomy: A systematic review and Procedure-specific Postoperative Pain Management recommendations (2024)
Journal Article
BACKGROUND Despite being a commonly performed surgical procedure, pain management for appendicectomy is often neglected because of insufficient evidence on the most effective treatment options. OBJECTIVE To provide evidence-based recommendatio... Read More about Perioperative pain management for appendicectomy: A systematic review and Procedure-specific Postoperative Pain Management recommendations.
A recurrent retrohepatic abscess secondary to a dropped appendicolith (2024)
Journal Article
Appendicoliths can drop into the peritoneal cavity during the course of an appendicectomy, or more commonly as a result of perforated appendicitis. We report the case of a patient with a history of recurrent retrohepatic abscesses over 7-year period... Read More about A recurrent retrohepatic abscess secondary to a dropped appendicolith.
Presentation and publication skills: How to review a paper (2023)
Journal Article
We provide comprehensive insights into the peer review process and guide potential reviewers through the steps of reviewing scientific manuscripts. We discuss essential aspects such as the reviewer’s responsibility in responding to invitations and ma... Read More about Presentation and publication skills: How to review a paper.
ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis (2023)
Journal Article
Both acute and chronic pancreatitis are frequent diseases of the pancreas, which, despite being of benign nature, are related to a significant risk of malnutrition and may require nutritional support. Acute necrotizing pancreatitis is encountered in... Read More about ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis.
Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years (2023)
Journal Article
Background While opioid analgesics are often necessary for the management of acute postoperative pain, appropriate prescribing practices are crucial to avoid harm. The aim was to investigate the changes in the proportion of people receiving initial... Read More about Temporal trends and patterns in initial opioid prescriptions after hospital discharge following colectomy in England over 10 years.
Management standards and burnout among surgeons in the United Kingdom (2023)
Journal Article
Background Burnout arising from chronic work-related stress is endemic among surgeons in the UK. Identification of contributory and modifiable psychosocial work characteristics could inform risk reduction activities. Aims We aimed to assess th... Read More about Management standards and burnout among surgeons in the United Kingdom.
Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells (2023)
Journal Article
Polymeric immunoglobulin receptor (PIGR) has a major role in mucosal immunity as a transporter of polymeric immunoglobulin across the epithelial cells. The aim of this study was to determine the effect of PIGR on cellular behaviours and chemo-sensiti... Read More about Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells.
The 2023 Sir David Cuthbertson Lecture. A fluid journey: Experiments that influenced clinical practice (2023)
Journal Article
This review summarises some of my work on fluid and electrolyte balance over the past 25 years and shows how the studies have influenced clinical practice. Missing pieces in the jigsaw are filled in by summarising the work of others. The main theme i... Read More about The 2023 Sir David Cuthbertson Lecture. A fluid journey: Experiments that influenced clinical practice.
PROSPECT methodology for developing procedure-specific pain management recommendations: an update (2023)
Journal Article
The procedure-specific postoperative pain management (PROSPECT) working group develops evidence-based pain management recommendations. PROSPECT methodology is unique and rigorous. However, several limitations were recognised that needed to be address... Read More about PROSPECT methodology for developing procedure-specific pain management recommendations: an update.