All Outputs (64)

Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient (2024)
Journal Article

Additive manufacturing offers manufacture of personalised pharmaceutical tablets through design freedoms and material deposition control at an individual voxel level. This control goes beyond geometry and materials choices: inkjet based 3D printing e... Read More about Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient.

Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient (2024)
Journal Article

Additive manufacturing offers manufacture of personalised pharmaceutical tablets through design freedoms and material deposition control at an individual voxel level. This control goes beyond geometry and materials choices: inkjet based 3D printing e... Read More about Enabling High-fidelity Personalized Pharmaceutical Tablets through Multimaterial Inkjet 3D Printing with a Water-soluble Excipient.

Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers (2023)
Journal Article

In the present study, novel gastroretentive bilayer tablets were developed that are promising for the once-a-day oral delivery of the drug candidate MT-1207. The gastroretentive layer consisted of a combination of hydrophilic and hydrophobic polymers... Read More about Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers.

Utilising micron scale 3D printed morphologies for particle adhesion reduction (2022)
Journal Article

In the pharmaceutical industry, the ability to improve the understanding of the effect of surface roughness on interparticulate interactions is critical. Dry powder inhalers often possess poor efficiency, as the powder formulations are inherently adh... Read More about Utilising micron scale 3D printed morphologies for particle adhesion reduction.

Functionalized Gold Nanoparticles with a Cohesion Enhancer for Robust Flexible Electrodes (2022)
Journal Article

The development of conductive inks is required to enable additive manufacturing of electronic components and devices. A gold nanoparticle (AuNP) ink is of particular interest due to its high electrical conductivity, chemical stability, and biocompati... Read More about Functionalized Gold Nanoparticles with a Cohesion Enhancer for Robust Flexible Electrodes.

Correction to “Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers” (2022)
Journal Article

The chemical structure of the drug trandolapril has been corrected in Figure 4c. The conclusions of the work have not been affected by this correction. (Figure present).

Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms (2021)
Journal Article

One of the most striking characteristics of 3D printing is its capability to produce multi-material objects with complex geometry. In pharmaceutics this translates to the possibility of dosage forms with multi-drug loading, tailored dosing and releas... Read More about Customisable Tablet Printing: The Development of Multimaterial Hot Melt Inkjet 3D Printing to Produce Complex and Personalised Dosage Forms.

Gastroretentive technologies in tandem with controlled-release strategies: A potent answer to oral drug bioavailability and patient compliance implications (2021)
Journal Article

There have been many efforts to improve oral drug bioavailability and therapeutic efficacy and patient compliance. A variety of controlled-release oral delivery systems have been developed to meet these needs. Gastroretentive drug delivery technologi... Read More about Gastroretentive technologies in tandem with controlled-release strategies: A potent answer to oral drug bioavailability and patient compliance implications.

Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers (2021)
Journal Article

Controlling the microstructure of materials by means of phase separation is a versatile tool for optimizing material properties. Phase separation has been exploited to fabricate intricate microstructures in many fields including cell biology, tissue... Read More about Bespoke 3D-Printed Polydrug Implants Created via Microstructural Control of Oligomers.

Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices (2021)
Journal Article

As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step change in the personalization of medical devices it is shown that multi-material inkjet-bas... Read More about Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices.

Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles (2021)
Journal Article

Inkjet printing of metal nanoparticles allows for design flexibility, rapid processing and enables the 3D printing of functional electronic devices through co-deposition of multiple materials. However, the performance of printed devices, especially t... Read More about Residual polymer stabiliser causes anisotropic electrical conductivity during inkjet printing of metal nanoparticles.

3D printed polymeric drug-eluting implants (2021)
Journal Article

An extrusion-based 3D printer has been used for the manufacturing of sustained drug release poly(ε-caprolactone) (PCL) implants. Such implants can address issues of reduced patient compliance due to the necessary frequent administration of convention... Read More about 3D printed polymeric drug-eluting implants.

In vitro and in vivo evaluation of a sustained-release once-a-day formulation of the novel antihypertensive drug MT-1207 (2021)
Journal Article

Hypertension is one of the most common chronic cardiovascular disorders. Sustained-release formulations are developed to maintain drug therapeutic levels throughout the treatment of hypertension, to promote patient compliance and improve patient outc... Read More about In vitro and in vivo evaluation of a sustained-release once-a-day formulation of the novel antihypertensive drug MT-1207.

A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation (2020)
Journal Article

© 2020 The Royal Society of Chemistry. Using a novel molecular design approach, we have prepared a thermo-responsive supramolecular polyurethane as a matrix material for use in drug eluting implants. The dynamic supramolecular polyurethane (SPU) is a... Read More about A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation.

A Reactive Prodrug Ink Formulation Strategy for Inkjet 3D Printing of Controlled Release Dosage Forms and Implants (2020)
Journal Article

We propose a strategy for creating tuneable 3D printed drug delivery devices. 3D printing offers the opportunity for improved compliance and patient treatment outcomes through personalisation, but bottlenecks include finding formulations that provide... Read More about A Reactive Prodrug Ink Formulation Strategy for Inkjet 3D Printing of Controlled Release Dosage Forms and Implants.

Development of an in vitro system to study the interactions of aerosolized drugs with pulmonary mucus (2020)
Journal Article

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Mucus is the first biological component inhaled drugs encounter on their journey towards their pharmacological target in the upper airways. Yet, how mucus may influence drug disposition and ef... Read More about Development of an in vitro system to study the interactions of aerosolized drugs with pulmonary mucus.

Is rat a good model for assessment of particulate-based taste-masked formulations? (2019)
Journal Article

Recently there has been an increased interest to develop specialised dosage forms that are better suited to specific patient populations, such as paediatrics and geriatrics. In these patient populations the acceptability of the oral dosage form can b... Read More about Is rat a good model for assessment of particulate-based taste-masked formulations?.

Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing (2019)
Journal Article

© 2019 In this study, we investigate the viability of three-dimensional (3D) inkjet printing with UV curing to produce solid dosage forms containing a known poorly soluble drug, carvedilol. The formulation consists of 10 wt% carvedilol, Irgacure 2959... Read More about Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing.

Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer (2019)
Journal Article

© 2019 Elsevier B.V. In the present study, we successfully developed a cetuximab-conjugated modified citrus pectin-chitosan nanoparticles for targeted delivery of curcumin (Cet-MCPCNPs) for the treatment of colorectal cancer. In vitro analyses reveal... Read More about Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer.

Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats (2019)
Journal Article

© 2019 Informa UK Limited, trading as Taylor & Francis Group. Oral delivery of amphotericin B (AmpB) is desirable because it provides a more patient-friendly mode of administration compared to the current delivery approach akin with the marketed Am... Read More about Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats.