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3D printed polymeric drug-eluting implants

Liaskoni, Athina; Wildman, Ricky D.; Roberts, Clive J.

Authors

Athina Liaskoni

RICKY WILDMAN RICKY.WILDMAN@NOTTINGHAM.AC.UK
Professor of Multiphase Flow and Mechanics



Abstract

An extrusion-based 3D printer has been used for the manufacturing of sustained drug release poly(ε-caprolactone) (PCL) implants. Such implants can address issues of reduced patient compliance due to the necessary frequent administration of conventional drug delivery systems, such as tablets, capsules and solutions. The selected model drug for this study was lidocaine. Polycaprolactone core-shell implants, as well as polymeric implants with no barrier shell were printed with different drug loading, without the addition of solvents or further excipients. Scanning Electron Microscopy (SEM) analysis revealed the structural integrity of the printed formulations, while Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD) and Attenuated Total Reflectance Fourier Transform Infrared spectroscopy (ATR-FTIR) were used to detect potential chemical interactions or modifications. Raman spectroscopy was also used to study material distribution in the prints. The drug release rate of the differently printed formulations was evaluated using a USP4 flow-through cell apparatus. All printed implants demonstrated sustained lidocaine release and the effectiveness of the PCL barrier in this regard. The Korsmeyer-Peppas model was suggested as the best fit to drug release profiles for all the produced implants. This work demonstrates that hot-melt extrusion-based 3D printing is a robust and promising technology for the production of personalisable drug-eluting implants.

Citation

Liaskoni, A., Wildman, R. D., & Roberts, C. J. (2021). 3D printed polymeric drug-eluting implants. International Journal of Pharmaceutics, 597, Article 120330. https://doi.org/10.1016/j.ijpharm.2021.120330

Journal Article Type Article
Acceptance Date Jan 27, 2021
Online Publication Date Feb 2, 2021
Publication Date Mar 15, 2021
Deposit Date Mar 31, 2021
Publicly Available Date Mar 29, 2024
Journal International Journal of Pharmaceutics
Print ISSN 0378-5173
Electronic ISSN 1873-3476
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 597
Article Number 120330
DOI https://doi.org/10.1016/j.ijpharm.2021.120330
Keywords Pharmaceutical Science
Public URL https://nottingham-repository.worktribe.com/output/5294279
Publisher URL https://www.sciencedirect.com/science/article/pii/S0378517321001344