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Nepal Family Cohort study: a study protocol (2024)
Journal Article
Kurmi, O. P., Chaudhary, N., Delanerolle, G., Bolton, C. E., Pant, P. R., Regmi, P. R., Gautam, S., Satia, I., Simkhada, P., Kyrou, I., Sigdel, T. K., Hundley, V., Dali, P. R., Løkke, A., Lam, K. B. H., Bennett, D., Custovic, A., van Teijlingen, E., Gill, P., Randeva, H., & O'Byrne, P. (2024). Nepal Family Cohort study: a study protocol. BMJ Open, 14(11), Article e088896. https://doi.org/10.1136/bmjopen-2024-088896

INTRODUCTION: The Nepal Family Cohort study uses a life course epidemiological approach to collect comprehensive data on children's and their parents' environmental, behavioural and metabolic risk factors. These factors can affect the overall develop... Read More about Nepal Family Cohort study: a study protocol.

DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19 (2024)
Journal Article
Gupta, A., Nicholas, R., McGing, J. J., Nixon, A. V., Mallinson, J. E., McKeever, T. M., Bradley, C. R., Piasecki, M., Cox, E. F., Bonnington, J., Lord, J. M., Brightling, C. E., Evans, R. A., Hall, I. P., Francis, S. T., Greenhaff, P. L., & Bolton, C. E. (2024). DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19. Experimental Physiology, 109(8), 1274-1291. https://doi.org/10.1113/ep091590

We evaluated the impacts of COVID-19 on multi-organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular disease were recruited... Read More about DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19.

Free-breathing Functional Pulmonary Proton MRI: A Novel Approach Using Voxel-wise Lung Ventilation (VOLVE) Assessment in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease (2024)
Journal Article
Peggs, Z. J., Brooke, J. P., Bolton, C. E., Hall, I. P., Francis, S. T., & Gowland, P. A. (2024). Free-breathing Functional Pulmonary Proton MRI: A Novel Approach Using Voxel-wise Lung Ventilation (VOLVE) Assessment in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease. Journal of Magnetic Resonance Imaging, https://doi.org/10.1002/jmri.29444

Background: In respiratory medicine, there is a need for sensitive measures of regional lung function that can be performed using standard imaging technology, without the need for inhaled or intravenous contrast agents. Purpose: To describe VOxel‐wis... Read More about Free-breathing Functional Pulmonary Proton MRI: A Novel Approach Using Voxel-wise Lung Ventilation (VOLVE) Assessment in Healthy Volunteers and Patients with Chronic Obstructive Pulmonary Disease.

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2024)
Journal Article
Shek, N., Choy, A.-M., Lang, C. C., Miller, B. E., Tal-Singer, R., Bolton, C. E., Thomson, N. C., Chalmers, J. D., Bown, M. J., Newby, D. E., Khan, F., & Huang, J. T. J. (2024). Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. npj Aging, 10(1), Article 15. https://doi.org/10.1038/s41514-024-00143-7

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and seve... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Accelerated immune ageing is associated with COVID-19 disease severity (2024)
Journal Article
Lord, J. M., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, A. G., Greening, N. J., McAuley, H. J. C., Evans, R. A., Moss, P., Moore, S. C., Turtle, L., Gautam, N., Gilani, A., Bajaj, M., Wain, L. V., Brightling, C., Raman, B., Marks, M., Singapuri, A., Elneima, O., …Bolton, C. E. (2024). Accelerated immune ageing is associated with COVID-19 disease severity. Immunity and Ageing, 21(1), Article 6. https://doi.org/10.1186/s12979-023-00406-z

Background: The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescence and ac... Read More about Accelerated immune ageing is associated with COVID-19 disease severity.

Balancing the value and risk of exercise-based therapy post-COVID-19: a narrative review (2023)
Journal Article
Singh, S. J., Daynes, E., McAuley, H. J., Raman, B., Greening, N. J., Chalder, T., Elneima, O., Evans, R. A., & Bolton, C. E. (2023). Balancing the value and risk of exercise-based therapy post-COVID-19: a narrative review. European Respiratory Review, 32(170), Article 230110. https://doi.org/10.1183/16000617.0110-2023

Coronavirus disease 2019 (COVID-19) can lead to ongoing symptoms such as breathlessness, fatigue and muscle pain, which can have a substantial impact on an individual. Exercise-based rehabilitation programmes have proven beneficial in many long-term... Read More about Balancing the value and risk of exercise-based therapy post-COVID-19: a narrative review.

Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study (2023)
Journal Article
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L.-P., Marks, M., Poinasamy, K., Raman, B., Shikotra, A., Singapuri, A., Sereno, M., Harris, V. C., Houchen-Wolloff, L., Saunders, R. M., Greening, N. J., Richardson, M., Quint, J. K., Briggs, A., Docherty, A. B., …Behalf of the PHOSP-COVID Collaborative Group, O. (2024). Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study. International Journal of Epidemiology, 53(1), Article dyad165. https://doi.org/10.1093/ije/dyad165

The Post-Hospitalisation COVID-19 (PHOSP-COVID) study is a national UK multicentre cohort study of patients who were hospitalized for COVID-19 and subsequently discharged.

PHOSP-COVID was established to investigate the medium- and long-term sequel... Read More about Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study.

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2023)
Preprint / Working Paper
Huang, J., Shek, N., Choy, A.-M., Lang, C., Miller, B., Tal-Singer, R., Bolton, C., Thomson, N., Newby, D., Chalmers, J., Khan, F., & Brown, M. Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation (2023)
Journal Article
Rajasekar, P., Hall, R. J., Binaya, K., Mahapatra, P. S., Puppala, S. P., Thakker, D., MacIsaac, J. L., Lin, D., Kobor, M., Bolton, C. E., Sayers, I., Hall, I. P., & Clifford, R. L. (2023). Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation. Environmental Pollution, 337, Article 122561. https://doi.org/10.1016/j.envpol.2023.122561

Household air pollution caused by inefficient cooking practices causes 4 million deaths a year worldwide. In Nepal, 86% of the rural population use solid fuels for cooking. Over 25% of premature deaths associated with air pollution are respiratory in... Read More about Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation.

Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis (2023)
Journal Article
Dawson, C., Clunie, G., Evison, F., Duncan, S., Whitney, J., Houchen-Wolloff, L., Bolton, C. E., Leavy, O. C., Richardson, M., Omer, E., McAuley, H., Shikotra, A., Singapuri, A., Sereno, M., Saunders, R. M., Harris, V. C., Greening, N. J., Nolan, C. M., Wootton, D. G., Daynes, E., …PHOSP-COVID collaborative Group. (2023). Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis. BMJ Open Respiratory Research, 10(1), Article e001647. https://doi.org/10.1136/bmjresp-2023-001647

Objective: Identify prevalence of self-reported swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19.

Design: Multicentre prospective observational cohort study using questionnaire data at visit 1 (2–7 mont... Read More about Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis.

Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS) (2023)
Journal Article
Siraj, R. A., Bolton, C. E., & McKeever, T. M. (2023). Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS). Thorax, 79(1), 50-57. https://doi.org/10.1136/thorax-2022-219736

Objective: To assess whether antidepressant prescriptions are associated with an increased risk of pneumonia and chronic obstructive pulmonary disease (COPD) exacerbation. Methods: A self-controlled case series was performed to investigate the rates... Read More about Association between antidepressants with pneumonia and exacerbation in patients with COPD: a self-controlled case series (SCCS).

Circulating testosterone levels and health outcomes in chronic obstructive pulmonary disease: results from ECLIPSE and ERICA (2023)
Journal Article
Pavey, H., Polkey, M. I., Bolton, C. E., Cheriyan, J., McEniery, C. M., Wilkinson, I., Mohan, D., Casaburi, R., Miller, B. E., Tal-Singer, R., & Fisk, M. (2023). Circulating testosterone levels and health outcomes in chronic obstructive pulmonary disease: results from ECLIPSE and ERICA. BMJ Open Respiratory Research, 10(1), Article e001601. https://doi.org/10.1136/bmjresp-2022-001601

The relationship of circulating testosterone levels with health outcomes in people with chronic obstructive pulmonary disease (COPD) is unknown.

Aim
To determine whether serum testosterone levels predict hospitalised acute exacerbations of COPD... Read More about Circulating testosterone levels and health outcomes in chronic obstructive pulmonary disease: results from ECLIPSE and ERICA.

Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID) (2023)
Preprint / Working Paper
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L.-P., Marks, M., Poinasamy, K., Raman, B., Shikotra, A., Singapuri, A., Sereno, M., Harris, V. C., Houchen-Wolloff, L., Saunders, R. M., Greening, N. J., Richardson, M., Quint, J. K., Briggs, A., Docherty, A. B., …on behalf of the PHOSP-COVID Collaborative Group. Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)

PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged.

PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitali... Read More about Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID).

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study (2023)
Journal Article
Jackson, C., Stewart, I. D., Plekhanova, T., Cunningham, P. S., Hazel, A. L., Al-Sheklly, B., Aul, R., Bolton, C. E., Chalder, T., Chalmers, J. D., Chaudhuri, N., Docherty, A. B., Donaldson, G., Edwardson, C. L., Elneima, O., Greening, N. J., Hanley, N. A., Harris, V. C., Harrison, E. M., Ho, L.-P., …Blaikley, J. F. (2023). Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. Lancet Respiratory Medicine, 11(8), 673-684. https://doi.org/10.1016/S2213-2600%2823%2900124-8

Sleep disturbance is common following hospital admission both for COVID-19 and other causes. The clinical associations of this for recovery after hospital admission are poorly understood despite sleep disturbance contributing to morbidity in other sc... Read More about Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study.

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study (2023)
Journal Article
McAuley, H. J., Evans, R. A., Bolton, C. E., Brightling, C. E., Chalmers, J. D., Docherty, A. B., Elneima, O., Greenhaff, P. L., Gupta, A., Harris, V. C., Harrison, E. M., Ho, L.-P., Horsley, A., Houchen-Wolloff, L., Jolley, C. J., Leavy, O. C., Lone, N. I., Man, W. D.-C., Marks, M., Parekh, D., …Greening, N. J. (2023). Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study. eClinicalMedicine, 57, Article 101896. https://doi.org/10.1016/j.eclinm.2023.101896

Background: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. Methods: This prospective cohort study recruited adults who had survived hospitalisation with clinically d... Read More about Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study.

The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study (2022)
Preprint / Working Paper
Jackson, C., Stewart, I., Plekhanova, T., Cunningham, P., Hazel, A. L., Al-Sheklly, B., Aul, R., Bolton, C. E., Chalder, T., Chalmers, J. D., Chaudhuri, N., Docherty, A. B., Donaldson, G., Edwardson, C. L., Elneima, O., Greening, N. J., Hanley, N. A., Harris, V. C., Harrison, E. M., Ho, L.-P., …Blaikley, J. F. The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study

Background

Sleep disturbance is common following hospitalisation both for COVID-19 and other causes. The clinical associations are poorly understood, despite it altering pathophysiology in other scenarios. We, therefore, investigated whether slee... Read More about The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study.

Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study (2022)
Journal Article
Plekhanova, T., Rowlands, A. V., Evans, R. A., Edwardson, C. L., Bishop, N. C., Bolton, C. E., Chalmers, J. D., Davies, M. J., Daynes, E., Dempsey, P. C., Docherty, A. B., Elneima, O., Greening, N. J., Greenwood, S. A., Hall, A. P., Harris, V. C., Harrison, E. M., Henson, J., Ho, L. P., Horsley, A., …PHOSP-COVID Collaborative Group. (2022). Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study. International Journal of Behavioral Nutrition and Physical Activity, 19(1), Article 94. https://doi.org/10.1186/s12966-022-01333-w

Background: The number of individuals recovering from severe COVID-19 is increasing rapidly. However, little is known about physical behaviours that make up the 24-h cycle within these individuals. This study aimed to describe physical behaviours fol... Read More about Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study.

Domesticating cleaner cookstoves for improved respiratory health: Using approaches from the sanitation sector to explore the adoption and sustained use of improved cooking technologies in Nepal (2022)
Journal Article
Jewitt, S., Smallman-Raynor, M., Binaya, C., Robinson, B., Adhikari, P., Evans, C., Karmacharya, B., Bolton, C. E., & Hall, I. P. (2022). Domesticating cleaner cookstoves for improved respiratory health: Using approaches from the sanitation sector to explore the adoption and sustained use of improved cooking technologies in Nepal. Social Science and Medicine, 308, Article 115201. https://doi.org/10.1016/j.socscimed.2022.115201

Drawing on village-based data from Nepal, this paper explores the transferability of the Integrated Behavioural Model for Water, Sanitation and Hygiene (IBM-WASH) to the clean cooking sector and its potential to elucidate how barriers to improved coo... Read More about Domesticating cleaner cookstoves for improved respiratory health: Using approaches from the sanitation sector to explore the adoption and sustained use of improved cooking technologies in Nepal.

Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation (2022)
Journal Article
Gupta, A., McKeever, T. M., Hutchinson, J. P., & Bolton, C. E. (2022). Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation. International Journal of Chronic Obstructive Pulmonary Disease, 2022(17), 535-544. https://doi.org/10.2147/copd.s345751

Purpose: People with COPD are at a higher risk of cognitive dysfunction than the general population. However, the additional impact of dementia amongst such patients is not well understood, particularly in those admitted with a COPD exacerbation. We... Read More about Impact of Coexisting Dementia on Inpatient Outcomes for Patients Admitted with a COPD Exacerbation.