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All Outputs (16)

Application of Mesenchymal Stem Cells Derived Artificial Microvesicles for the Treatment of Canine Skin Wound (2021)
Journal Article
Zakirova, E., Valeeva, A., Sofronova, S., Tambovsky, M., Rutland, C., Rizvanov, A., & Gomzikova, M. (2022). Application of Mesenchymal Stem Cells Derived Artificial Microvesicles for the Treatment of Canine Skin Wound. BioNanoScience, 12(1), 83-88. https://doi.org/10.1007/s12668-021-00928-0

Large full-thickness skin defects represent a serious veterinary problem. We have developed a novel therapy for canine skin wounds using extracellular vesicles derived from mesenchymal stem cells. Successful wound healing was observed with a positive... Read More about Application of Mesenchymal Stem Cells Derived Artificial Microvesicles for the Treatment of Canine Skin Wound.

Why Do We Need Maths in Medicine? (2021)
Journal Article
Cockcroft, J., Saigar, M., Dawkins, A., & Rutland, C. S. (2021). Why Do We Need Maths in Medicine?. Frontiers for Young Minds, 9, Article 678802. https://doi.org/10.3389/frym.2021.678802

Maths is a crucial part of medicine. All the graphs, equations, statistics, and general maths we learn at school help us to understand important aspects of human and veterinary medicine, biology, and science in general. People always think that biolo... Read More about Why Do We Need Maths in Medicine?.

Comparative pathology of dog and human prostate cancer (2021)
Journal Article
Ryman-Tubb, T., Lothion-Roy, J. H., Metzler, V. M., Harris, A. E., Robinson, B. D., Rizvanov, A. A., Jeyapalan, J. N., James, V. H., England, G., Rutland, C. S., Persson, J. L., Kenner, L., Rubin, M. A., Mongan, N. P., & de Brot, S. (2022). Comparative pathology of dog and human prostate cancer. Veterinary Medicine and Science, 8(1), 110-120. https://doi.org/10.1002/vms3.642

Though relatively rare in dogs, prostate cancer (PCa) is the most common non-cutaneous cancer in men. Human and canine prostate glands share many functional, anatomical and physiological features. Due to these similarities, canine PCa has been propos... Read More about Comparative pathology of dog and human prostate cancer.

Recent Advances in Experimental Dendritic Cell Vaccines for Cancer (2021)
Journal Article
Filin, I. Y., Kitaeva, K. V., Rutland, C. S., Rizvanov, A. A., & Solovyeva, V. V. (2021). Recent Advances in Experimental Dendritic Cell Vaccines for Cancer. Frontiers in Oncology, 11, 1-7. https://doi.org/10.3389/fonc.2021.730824

The development of immunotherapeutic methods for the treatment of oncological diseases have made it possible to improve the effectiveness of standard therapies. There was no breakthrough after first using of personalized therapeutic vaccines based on... Read More about Recent Advances in Experimental Dendritic Cell Vaccines for Cancer.

Morphological investigation of canine epigastric organs and adjacent structures via computed tomography, ultrasound and anatomical prosection (2021)
Journal Article
Alsafy, M. A., Hanafy, B. G., Rutland, C. S., Karkoura, A. A., Enany, E.-S., & El-gendy, S. A. (2022). Morphological investigation of canine epigastric organs and adjacent structures via computed tomography, ultrasound and anatomical prosection. Morphologie, 106(355), 271-286. https://doi.org/10.1016/j.morpho.2021.08.001

The canine epigastric organs, their locations and visualization of these components are essential for veterinary practice and anatomical research. Despite their importance, conflicts and discrepancies in the published material, to date, still exist,... Read More about Morphological investigation of canine epigastric organs and adjacent structures via computed tomography, ultrasound and anatomical prosection.

Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma (2021)
Journal Article
Rutland, C. S., Cockcroft, J. M., Lothion-Roy, J., Harris, A. E., Jeyapalan, J. N., Simpson, S., Alibhai, A., Bailey, C., Ballard-Reisch, A. C., Rizvanov, A. A., Dunning, M. D., de Brot, S., & Mongan, N. P. (2021). Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma. Frontiers in Veterinary Science, 8, Article 704598. https://doi.org/10.3389/fvets.2021.704598

Osteosarcoma (OSA) is an aggressive bone malignancy. Unlike many other malignancies, OSA outcomes have not improved in recent decades. One challenge to the development of better diagnostic and therapeutic methods for OSA has been the lack of well cha... Read More about Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma.

A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions (2021)
Journal Article
Blanchard, A. M., Staley, C. E., Shaw, L., Wattegedera, S. R., Baumbach, C.-M., Michler, J. K., Rutland, C., Back, C., Newbold, N., Entrican, G., & Tötemeyer, S. (2021). A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions. Infection and Immunity, 89(10), Article e00270-21. https://doi.org/10.1128/iai.00270-21

Footrot is a polymicrobial infectious disease in sheep causing severe lameness, leading to one of the industry’s largest welfare problems. The complex etiology of footrot makes in situ or in vitro investigations difficult. Computational methods offer... Read More about A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions.

Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors (2021)
Journal Article
Gatina, D. Z., Garanina, E. E., Zhuravleva, M. N., Synbulatova, G. E., Mullakhmetova, A. F., Solovyeva, V. V., Kiyasov, A. P., Rutland, C. S., Rizvanov, A. A., & Salafutdinov, I. I. (2021). Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors. International Journal of Molecular Sciences, 22(11), Article 5922. https://doi.org/10.3390/ijms22115922

Coronary artery disease remains one of the primary healthcare problems due to the high cost of treatment, increased number of patients, poor clinical outcomes, and lack of effective therapy. Though pharmacological and surgical treatments positively a... Read More about Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors.

Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy (2021)
Book Chapter
Simpson, S., Kordtomeikel, K.-Z., Wong, S., Bennison, S., El-Gendy, S. A., Cobb, M., & Rutland, C. S. (2021). Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy. In C. Rutland (Ed.), Canine Medicine : Recent Topics and Advanced Research (1-22). InTech. https://doi.org/10.5772/intechopen.97682

Dilated cardiomyopathy involves enlargement of the ventricular chamber and systolic dysfunction. The reduction in quality of life and increased levels of congestive heart failure, combined with the high diagnosis rate within the canine population, hi... Read More about Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy.

A history of lameness and low body condition score is associated with reduced digital cushion volume, measured by magnetic resonance imaging, in dairy cattle (2021)
Journal Article
Wilson, J. P., Randall, L. V., Green, M. J., Rutland, C. S., Bradley, C. R., Ferguson, H. J., Bagnall, A., & Huxley, J. N. (2021). A history of lameness and low body condition score is associated with reduced digital cushion volume, measured by magnetic resonance imaging, in dairy cattle. Journal of Dairy Science, 104(6), 7026-7038. https://doi.org/10.3168/jds.2020-19843

Claw horn lesions (CHL) are the result of a failing of the functional anatomy of the hoof in dairy cows. The digital cushion is understood to be a vital structure in the prevention of CHL. Claw horn lesions have previously been shown to lead to patho... Read More about A history of lameness and low body condition score is associated with reduced digital cushion volume, measured by magnetic resonance imaging, in dairy cattle.

Morphology, adipocyte size, and fatty acid analysis of dairy cattle digital cushions, and the effect of body condition score and age (2021)
Journal Article
Newsome, R. F., Mostyn, A., Wilson, J. P., Alibhai, A., Bollard, N., Randall, L., Chagunda, M. G. G., Sturrock, C. J., Keane, M., Green, M., Huxley, J. N., & Rutland, C. S. (2021). Morphology, adipocyte size, and fatty acid analysis of dairy cattle digital cushions, and the effect of body condition score and age. Journal of Dairy Science, 104(5), https://doi.org/10.3168/jds.2020-19388

The digital cushion is an essential part of maintaining a healthy foot, working to dissipate foot strike and body weight forces and lameness from claw horn disruption lesions. Despite the importance of the digital cushion, little is known about the b... Read More about Morphology, adipocyte size, and fatty acid analysis of dairy cattle digital cushions, and the effect of body condition score and age.

Skeleton Growth in Guinea Pigs and Humans (2021)
Journal Article
Skinner, Z., Clark, N., Rutland, S., Dawkins, A., & Rutland, C. S. (2021). Skeleton Growth in Guinea Pigs and Humans. Frontiers for Young Minds, 9, Article 561416

Every animal has a skeleton made up of many different bones. Bones are vital. Without bones we would not be able to move, protect our internal organs, store important minerals, or even make some cell types! When we are young, in addition to growing,... Read More about Skeleton Growth in Guinea Pigs and Humans.