Application of Mesenchymal Stem Cells Derived Artificial Microvesicles for the Treatment of Canine Skin Wound

Zakirova, Elena; Valeeva, Anastasiya; Sofronova, Svetlana; Tambovsky, Maksim; Rutland, Catrin; Rizvanov, Albert; Gomzikova, Marina

Abstract

Large full-thickness skin defects represent a serious veterinary problem. We have developed a novel therapy for canine skin wounds using extracellular vesicles derived from mesenchymal stem cells. Successful wound healing was observed with a positive clinical outcome for the canine patient. The extracellular vesicles stimulated a regenerative process in the skin in comparison to classic therapy. This represents a novel and innovative method for exploring would healing and disorders requiring regeneration.

Citation

Zakirova, E., Valeeva, A., Sofronova, S., Tambovsky, M., Rutland, C., Rizvanov, A., & Gomzikova, M. (2022). Application of Mesenchymal Stem Cells Derived Artificial Microvesicles for the Treatment of Canine Skin Wound. BioNanoScience, 12(1), 83-88. https://doi.org/10.1007/s12668-021-00928-0

• Journal Article Type: Article
• Acceptance Date: Nov 18, 2021
• Online Publication Date: Nov 27, 2021
• Publication Date: 2022-03
• Deposit Date: Nov 6, 2024
• Journal: BioNanoScience
• Print ISSN: 2191-1630
• Electronic ISSN: 2191-1649
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 1
• Pages: 83-88
• DOI: https://doi.org/10.1007/s12668-021-00928-0
• Keywords: Cytochalasin B-induced membrane vesicles · Microvesicles · Skin damage · Regeneration
• Public URL: https://nottingham-repository.worktribe.com/output/25076353
• Publisher URL: https://link.springer.com/article/10.1007/s12668-021-00928-0
• Additional Information: Accepted: 18 November 2021; First Online: 27 November 2021; : ; : The protocol of study was approved by the Biomedicine Ethic Expert Committee of Kazan Federal University (protocol 3; date 5th May 2015) under institutional and international ethical guidelines. Injections and care were given in accordance with standard veterinary practice recommendations by qualified clinicians with additional health and welfare checks and clinical observations.; : All authors consent to the publication of this article.; : The authors declare no competing interests.