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All Outputs (19)

Current Trends in Cancer Immunotherapy (2020)
Journal Article
Filin, I. Y., Solovyeva, V. V., Kitaeva, K. V., Rutland, C. S., & Rizvanov, A. A. (2020). Current Trends in Cancer Immunotherapy. Biomedicines, 8(12), 1-36. https://doi.org/10.3390/biomedicines8120621

The search for an effective drug to treat oncological diseases, which have become the main scourge of mankind, has generated a lot of methods for studying this affliction. It has also become a serious challenge for scientists and clinicians who have... Read More about Current Trends in Cancer Immunotherapy.

The Importance of Anatomy (2020)
Journal Article
Stanford, K., Rutland, S., Sturrock, C. J., & Rutland, C. S. (2020). The Importance of Anatomy. Frontiers for Young Minds, 8, Article 546763. https://doi.org/10.3389/frym.2020.546763

Anatomy is the knowledge about the structure of the bodies of animals and people. This includes information about blood vessels, organs, the skeleton, and nerves. But have you ever wondered where the anatomical information in science books and websit... Read More about The Importance of Anatomy.

Health Care Providers’ Awareness on Medical Management of Children With Autism Spectrum Disorder: Cross-Sectional Study in Russia (2020)
Preprint / Working Paper
Mukhamedshina, Y., Fayzullina, R., Nigmatullina, I., Rutland, C., & Vasina, V. (2020). Health Care Providers’ Awareness on Medical Management of Children With Autism Spectrum Disorder: Cross-Sectional Study in Russia

Background: Autism spectrum disorder (ASD) is a complex developmental range of conditions that involves difficulties with social interaction and restricted/repetitive behaviors. Unfortunately, health care providers often experience difficulties in di... Read More about Health Care Providers’ Awareness on Medical Management of Children With Autism Spectrum Disorder: Cross-Sectional Study in Russia.

Methods for studying endocytotic pathways of herpesvirus encoded g protein-coupled receptors (2020)
Journal Article
Mavri, M., Spiess, K., Rosenkilde, M. M., Rutland, C. S., Vrecl, M., & Kubale, V. (2020). Methods for studying endocytotic pathways of herpesvirus encoded g protein-coupled receptors. Molecules, 25(23), Article 5710. https://doi.org/10.3390/molecules25235710

Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. This enables cells to communicate and respond to external environments, maintain cellular homeost... Read More about Methods for studying endocytotic pathways of herpesvirus encoded g protein-coupled receptors.

Extracellular Vesicles: New Perspectives of Regenerative and Reproductive Veterinary Medicine (2020)
Journal Article
Zakirova, E. Y., Aimaletdinov, A. M., Malanyeva, A. G., Rutland, C. S., & Rizvanov, A. A. (2020). Extracellular Vesicles: New Perspectives of Regenerative and Reproductive Veterinary Medicine. Frontiers in Veterinary Science, 7, Article 594044. https://doi.org/10.3389/fvets.2020.594044

Extracellular vesicles are released by all cell types including stem cells. Stem cell-released extracellular vesicles have therapeutic effects similar to those of their parent cells and have regenerative effects in tissues. They also have an immunomo... Read More about Extracellular Vesicles: New Perspectives of Regenerative and Reproductive Veterinary Medicine.

Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 Dopamine Receptor (D2-R) Isoforms (2020)
Journal Article
Blagotinšek Cokan, K., Mavri, M., Rutland, C. S., Glišić, S., Senćanski, M., Vrecl, M., & Kubale, V. (2020). Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 Dopamine Receptor (D2-R) Isoforms. Biomolecules, 10(10), Article 1355. https://doi.org/10.3390/biom10101355

The type 2 dopamine receptor D2 (D2-R), member of the G protein-coupled receptor (GPCR) superfamily, exists in two isoforms, short (D2S-R) and long (D2L-R). They differ by an additional 29 amino acids (AA) in the third cytoplasmic loop (ICL3) of the... Read More about Critical Impact of Different Conserved Endoplasmic Retention Motifs and Dopamine Receptor Interacting Proteins (DRIPs) on Intracellular Localization and Trafficking of the D2 Dopamine Receptor (D2-R) Isoforms.

Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine (2020)
Journal Article
Gilazieva, Z., Ponomarev, A., Rutland, C., Rizvanov, A., & Solovyeva, V. (2020). Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine. Cancers, 12(10), Article 2727. https://doi.org/10.3390/cancers12102727

One of the promising directions in personalized medicine is the use of three-dimensional (3D) tumor models such as spheroids and organoids. Spheroids and organoids are three-dimensional cultures of tumor cells that can be obtained from patient tissue... Read More about Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine.

Molecular characterisation of canine osteosarcoma in high risk breeds (2020)
Journal Article
Simpson, S., Dunning, M., de Brot, S., Alibhai, A., Bailey, C., Woodcock, C. L., Mestas, M., Akhtar, S., Jeyapalan, J. N., Lothion-Roy, J., Emes, R. D., Allegrucci, C., Rizvanov, A. A., Mongan, N. P., & Rutland, C. S. (2020). Molecular characterisation of canine osteosarcoma in high risk breeds. Cancers, 12(9), Article 2405. https://doi.org/10.3390/cancers12092405

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Dogs develop osteosarcoma (OSA) and the disease process closely resembles that of human OSA. OSA has a poor prognosis in both species and disease-free intervals and cure rates have not improve... Read More about Molecular characterisation of canine osteosarcoma in high risk breeds.

Can Toothache Cause Heartbreak? (2020)
Journal Article
Clark, N., Skinner, Z., & Rutland, C. S. (2020). Can Toothache Cause Heartbreak?. Frontiers for Young Minds, 8, Article 87. https://doi.org/10.3389/frym.2020.00087

Poor mouth care and heart disease are two major health concerns worldwide. Both conditions occur in humans and in many mammals, including our pets. “Periodontal” is the word used to refer to structures surrounding the teeth, including the gums and bo... Read More about Can Toothache Cause Heartbreak?.

Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses (2020)
Book Chapter
Zakirova, E., Milomir, K., Zhuravleva, M., Rutland, C., & Rizvanov, A. (2020). Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses. In C. Rutland, & A. Rizvanov (Eds.), Equine science. InTech. https://doi.org/10.5772/intechopen.92352

Tendon and ligament injuries have always been complex to treat, with recovery often taking many months, if successful at all. This chapter looks at recent work undertaken using regenerative medicine, specifically gene therapy and the advances that ha... Read More about Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses.

Discovery of os cordis in the cardiac skeleton of chimpanzees (Pan troglodytes) (2020)
Journal Article
Moittié, S., Baiker, K., Strong, V., Cousins, E., White, K., Liptovszky, M., Redrobe, S., Alibhai, A., Sturrock, C. J., & Rutland, C. S. (2020). Discovery of os cordis in the cardiac skeleton of chimpanzees (Pan troglodytes). Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-66345-7

© 2020, The Author(s). Cardiovascular diseases, especially idiopathic myocardial fibrosis, is one of the most significant causes of morbidity and mortality in captive great apes. This study compared the structure and morphology of 16 hearts from chim... Read More about Discovery of os cordis in the cardiac skeleton of chimpanzees (Pan troglodytes).

Mouse Tumor Models for Advanced Cancer Immunotherapy (2020)
Journal Article
Chulpanova, D. S., Kitaeva, K. V., Rutland, C. S., Rizvanov, A. A., & Solovyeva, V. V. (2020). Mouse Tumor Models for Advanced Cancer Immunotherapy. International Journal of Molecular Sciences, 21(11), Article 4118. https://doi.org/10.3390/ijms21114118

Recent advances in the development of new methods of cancer immunotherapy require the production of complex cancer animal models that reliably reflect the complexity of the tumor and its microenvironment. Mice are good animals to create tumor models... Read More about Mouse Tumor Models for Advanced Cancer Immunotherapy.

The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy (2020)
Book Chapter
Kubale, V., Prozorowska, E., Glocová, K., Slater, L., & Rutland, C. (2020). The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy. In D. Gaze (Ed.), . IntechOpen. https://doi.org/10.5772/intechopen.92628

The G-protein-coupled receptors (GPCRs, also called seven-transmembrane receptor, 7TMRs, or heptahelical receptor) are a conserved family of seven transmembrane receptors which are essential not only in the healthy heart and blood vessels but also in... Read More about The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy.

Epidemiology and risk factors of osteosarcoma (2020)
Journal Article
Sadykova, L. R., Ntekim, A. I., Muyangwa-Semenova, M., Rutland, C. S., Jeyapalan, J. N., Blatt, N., & Rizvanov, A. (2020). Epidemiology and risk factors of osteosarcoma. Cancer Investigation, 38(5), 259-269. https://doi.org/10.1080/07357907.2020.1768401

Osteosarcoma is a rare tumor diagnosed at any age; however younger age is a common risk factor. In addition, multiple factors are believed to contribute to higher rates of osteosarcoma, particularly race and gender. Although diagnosed worldwide, oste... Read More about Epidemiology and risk factors of osteosarcoma.

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening (2020)
Journal Article
Solovyeva, V. V., Kitaeva, K. V., Rutland, C. S., & Rizvanov, A. A. (2020). Cell Culture Based in vitro Test Systems for Anticancer Drug Screening. Frontiers in Bioengineering and Biotechnology, 8, Article 322. https://doi.org/10.3389/fbioe.2020.00322

The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern. The choice of t... Read More about Cell Culture Based in vitro Test Systems for Anticancer Drug Screening.

Blood Vessels Under the Microscope (2020)
Journal Article
Machado, M. J. C., Mitchell, C. A., Franklin, J., Thorpe, A., & Rutland, C. S. (2020). Blood Vessels Under the Microscope. Frontiers for Young Minds, 7, Article 151. https://doi.org/10.3389/frym.2019.00151

This paper looks at blood vessels. All humans and animals have blood vessels, including your pet rabbit or dog, a whale or a giraffe! We need blood vessels to stay alive. This paper answers many questions, including what blood vessels are used for an... Read More about Blood Vessels Under the Microscope.