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Mouse Tumor Models for Advanced Cancer Immunotherapy

Chulpanova, Daria S.; Kitaeva, Kristina V.; Rutland, Catrin S.; Rizvanov, Albert A.; Solovyeva, Valeriya V.

Authors

Daria S. Chulpanova

Kristina V. Kitaeva

Catrin S. Rutland

Albert A. Rizvanov

Valeriya V. Solovyeva



Abstract

Recent advances in the development of new methods of cancer immunotherapy require the production of complex cancer animal models that reliably reflect the complexity of the tumor and its microenvironment. Mice are good animals to create tumor models because they are low cost, have a short reproductive cycle, exhibit high tumor growth rates, and can be easily genetically modified. However, the obvious problem of these models is the high failure rate observed in human clinical trials after promising results obtained in mouse models. In order to increase the reliability of the results obtained in mice, the tumor model should reflect the heterogeneity of the tumor, contain components of the tumor microenvironment, in particular immune cells, to which the action of immunotherapeutic drugs are directed. This review discusses the current immunocompetent and immunocompromised mouse models of human tumors that are used to evaluate the effectiveness of immunotherapeutic agents, in particular chimeric antigen receptor (CAR) T-cells and immune checkpoint inhibitors.

Journal Article Type Article
Publication Date Jun 9, 2020
Journal International Journal of Molecular Sciences
Print ISSN 1661-6596
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 21
Issue 11
Article Number 4118
APA6 Citation Chulpanova, D. S., Kitaeva, K. V., Rutland, C. S., Rizvanov, A. A., & Solovyeva, V. V. (2020). Mouse Tumor Models for Advanced Cancer Immunotherapy. International Journal of Molecular Sciences, 21(11), https://doi.org/10.3390/ijms21114118
DOI https://doi.org/10.3390/ijms21114118
Keywords cancer mouse models; cancer immunotherapy; immune checkpoint inhibitors; CAR Tcell therapy
Publisher URL https://www.mdpi.com/1422-0067/21/11/4118
Additional Information Chulpanova, D.S.; Kitaeva, K.V.; Rutland, C.S.; Rizvanov, A.A.; Solovyeva, V.V. Mouse Tumor Models for Advanced Cancer Immunotherapy. Int. J. Mol. Sci. 2020, 21, 4118.

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