Mouse Tumor Models for Advanced Cancer Immunotherapy

Chulpanova, Daria S.; Kitaeva, Kristina V.; Rutland, Catrin S.; Rizvanov, Albert A.; Solovyeva, Valeriya V.

Abstract

Recent advances in the development of new methods of cancer immunotherapy require the production of complex cancer animal models that reliably reflect the complexity of the tumor and its microenvironment. Mice are good animals to create tumor models because they are low cost, have a short reproductive cycle, exhibit high tumor growth rates, and can be easily genetically modified. However, the obvious problem of these models is the high failure rate observed in human clinical trials after promising results obtained in mouse models. In order to increase the reliability of the results obtained in mice, the tumor model should reflect the heterogeneity of the tumor, contain components of the tumor microenvironment, in particular immune cells, to which the action of immunotherapeutic drugs are directed. This review discusses the current immunocompetent and immunocompromised mouse models of human tumors that are used to evaluate the effectiveness of immunotherapeutic agents, in particular chimeric antigen receptor (CAR) T-cells and immune checkpoint inhibitors.

Citation

Chulpanova, D. S., Kitaeva, K. V., Rutland, C. S., Rizvanov, A. A., & Solovyeva, V. V. (2020). Mouse Tumor Models for Advanced Cancer Immunotherapy. International Journal of Molecular Sciences, 21(11), Article 4118. https://doi.org/10.3390/ijms21114118

• Journal Article Type: Article
• Acceptance Date: Jun 6, 2020
• Online Publication Date: Jun 9, 2020
• Publication Date: Jun 9, 2020
• Deposit Date: Jun 10, 2020
• Publicly Available Date: Jun 10, 2020
• Journal: International Journal of Molecular Sciences
• Print ISSN: 1661-6596
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 11
• Article Number: 4118
• DOI: https://doi.org/10.3390/ijms21114118
• Keywords: cancer mouse models; cancer immunotherapy; immune checkpoint inhibitors; CAR Tcell therapy
• Public URL: https://nottingham-repository.worktribe.com/output/4618126
• Publisher URL: https://www.mdpi.com/1422-0067/21/11/4118
• Additional Information: Chulpanova, D.S.; Kitaeva, K.V.; Rutland, C.S.; Rizvanov, A.A.; Solovyeva, V.V. Mouse Tumor Models for Advanced Cancer Immunotherapy. Int. J. Mol. Sci. 2020, 21, 4118.