Valeriya V. Solovyeva
Cell Culture Based in vitro Test Systems for Anticancer Drug Screening
Solovyeva, Valeriya V.; Kitaeva, Kristina V.; Rutland, Catrin S.; Rizvanov, Albert A.
Authors
Kristina V. Kitaeva
CATRIN RUTLAND CATRIN.RUTLAND@NOTTINGHAM.AC.UK
Professor of Molecular Medicine
Albert A. Rizvanov
Abstract
The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern. The choice of the correct tumor model at the stage of in vitro testing provides reduction in both financial and time costs during later stages due to the timely screening of ineffective agents. In view of the growing incidence of oncology, increasing the pace of the creation, development and testing of new antitumor agents, the improvement and expansion of new high-tech systems for preclinical in vitro screening is becoming very important. The pharmaceutical industry presently relies on several widely used in vitro models, including two-dimensional models, three-dimensional models, microfluidic systems, Boyden’s chamber and models created using 3D bioprinting. This review outlines and describes these tumor models including their use in research, in addition to their characteristics. This review therefore gives an insight into in vitro based testing which is of interest to researchers and clinicians from differing fields including pharmacy, preclinical studies and cell biology.
Citation
Solovyeva, V. V., Kitaeva, K. V., Rutland, C. S., & Rizvanov, A. A. (2020). Cell Culture Based in vitro Test Systems for Anticancer Drug Screening. Frontiers in Bioengineering and Biotechnology, 8, Article 322. https://doi.org/10.3389/fbioe.2020.00322
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 24, 2020 |
Online Publication Date | Apr 9, 2020 |
Publication Date | Apr 9, 2020 |
Deposit Date | Apr 17, 2020 |
Publicly Available Date | Apr 17, 2020 |
Journal | Frontiers in Bioengineering and Biotechnology |
Electronic ISSN | 2296-4185 |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 8 |
Article Number | 322 |
DOI | https://doi.org/10.3389/fbioe.2020.00322 |
Keywords | Biotechnology; Bioengineering; Histology; Biomedical Engineering |
Public URL | https://nottingham-repository.worktribe.com/output/4300075 |
Publisher URL | https://www.frontiersin.org/articles/10.3389/fbioe.2020.00322/full |
Files
Cell culture based in vitro Rutland 2020 front
(1.7 Mb)
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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